Entrez gene ID | | 6622 |
Official gene symbol | | SNCA |
Full name | | synuclein, alpha (non A4 component of amyloid precursor) |
Aliases | | ,MGC110988,NACP,PARK1,PARK4,PD1, |
Gene summary | | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q21 |
Gene position | | 90759447 - 90645250 Map Viewer |
Gene orientation | | minus |
Gene size | | 114198 bp |
Gene sequence |
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OMIM ID | | 163890 |