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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SNCA (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001774 microglial cell activation IEA GO:0001921 positive regulation of receptor recycling IDA GO:0001956 positive regulation of neurotransmitter secretion IEA GO:0001963 synaptic transmission, dopaminergic IEA GO:0006631 fatty acid metabolic process IEA GO:0006638 neutral lipid metabolic process IEA GO:0006644 phospholipid metabolic process IEA GO:0006916 anti-apoptosis IMP GO:0006919 activation of caspase activity IDA GO:0007006 mitochondrial membrane organization IEA GO:0008219 cell death IEA GO:0008344 adult locomotory behavior IEA GO:0010040 response to iron(II) ion IDA GO:0010517 regulation of phospholipase activity IDA GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA GO:0014048 regulation of glutamate secretion IEA GO:0014059 regulation of dopamine secretion IEA GO:0031115 negative regulation of microtubule polymerization IDA GO:0031623 receptor internalization IDA GO:0032026 response to magnesium ion IDA GO:0032410 negative regulation of transporter activity IDA GO:0032496 response to lipopolysaccharide IDA GO:0032769 negative regulation of monooxygenase activity IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA GO:0033138 positive regulation of peptidyl-serine phosphorylation ISS GO:0034341 response to interferon-gamma IDA GO:0034599 cellular response to oxidative stress IEA GO:0035067 negative regulation of histone acetylation IDA GO:0040012 regulation of locomotion IEA GO:0042416 dopamine biosynthetic process IEA GO:0042493 response to drug IEA GO:0042775 mitochondrial ATP synthesis coupled electron transport IEA GO:0043030 regulation of macrophage activation IEA GO:0043154 negative regulation of caspase activity IDA GO:0043154 negative regulation of caspase activity IMP GO:0043524 negative regulation of neuron apoptosis IEA GO:0045807 positive regulation of endocytosis IDA GO:0045920 negative regulation of exocytosis IMP GO:0048169 regulation of long-term neuronal synaptic plasticity IEA GO:0048488 synaptic vesicle endocytosis IEA GO:0048488 synaptic vesicle endocytosis ISS GO:0050812 regulation of acyl-CoA biosynthetic process IEA GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA GO:0051585 negative regulation of dopamine uptake IDA GO:0051612 negative regulation of serotonin uptake IDA GO:0051622 negative regulation of norepinephrine uptake IDA GO:0055074 calcium ion homeostasis IDA GO:0060079 regulation of excitatory postsynaptic membrane potential IEA GO:0060291 long-term synaptic potentiation IEA GO:0060732 positive regulation of inositol phosphate biosynthetic process IDA GO:0070495 negative regulation of thrombin receptor signaling pathway IDA GO:0070555 response to interleukin-1 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IDA cellular_component GO:0005576 extracellular region TAS GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol IDA GO:0005829 cytosol IEA GO:0005856 cytoskeleton IEA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane IEA GO:0005938 cell cortex IDA GO:0015629 actin cytoskeleton IDA GO:0019717 synaptosome IEA GO:0030054 cell junction IEA GO:0030424 axon IDA GO:0030426 growth cone IDA GO:0031092 platelet alpha granule membrane IDA GO:0043205 fibril IDA GO:0045202 synapse IEA molecular_function GO:0000287 magnesium ion binding IDA GO:0005504 fatty acid binding IDA GO:0005509 calcium ion binding IDA GO:0005515 protein binding IPI GO:0008198 ferrous iron binding IDA GO:0008270 zinc ion binding IDA GO:0019894 kinesin binding IPI GO:0030544 Hsp70 protein binding IPI GO:0042393 histone binding IDA GO:0042393 histone binding IEA GO:0042802 identical protein binding IEA GO:0042802 identical protein binding IPI GO:0043014 alpha-tubulin binding IPI GO:0043027 caspase inhibitor activity IDA GO:0045502 dynein binding IPI GO:0048156 tau protein binding IDA GO:0050544 arachidonic acid binding IEA GO:0051219 phosphoprotein binding IDA GO:0060961 phospholipase D inhibitor activity IDA

Protein-protein interaction details for SNCA (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SNCAIP Two-hybrid physical 12044636 SEPT4 Affinity Capture-Western physical 12695511 SEPT2 Affinity Capture-Western physical 12695511 SLC6A3 Affinity Capture-Western physical 12672538 SLC6A3 Affinity Capture-Western physical 12672538 PLD1 Affinity Capture-Western physical 11821392 PLD1 Reconstituted Complex physical 11821392 SNCAIP Affinity Capture-Western physical 11742726 BAX Reconstituted Complex physical 11742726 BAD Reconstituted Complex physical 11742726 MAPK3 Affinity Capture-Western physical 12121974 MAPK1 Affinity Capture-Western physical 12121974 MAPK8 Affinity Capture-Western physical 12121974 SNCAIP FRET physical 11331421 SNCB Affinity Capture-Western physical 11683992 MAPT Reconstituted Complex physical 10464279 MAPT Co-purification physical 10464279 TOR1A FRET physical 11438481 CALM1 Reconstituted Complex physical 12358748 SNCAIP Two-hybrid physical 10319874 SNCAIP Reconstituted Complex physical 10319874 SNCAIP Affinity Capture-Western physical 10319874 FYN Biochemical Activity physical 11162638 APP Reconstituted Complex physical 9163350 MAP1B Reconstituted Complex physical 10764738 PARK2 Affinity Capture-Western physical 11588587 PARK2 Affinity Capture-Western physical 11588587 GRK5 Biochemical Activity physical 10852916 GRK1 Biochemical Activity physical 10852916 GRK6 Biochemical Activity physical 10852916 SLC6A3 Affinity Capture-Western physical 11292651 SLC6A3 Two-hybrid physical 11292651 PARK2 Affinity Capture-Western physical 18195004 UBC Affinity Capture-Western physical 17635667 UBC Affinity Capture-Western physical 17635667 PARK2 Affinity Capture-Western physical 16714300 SNCA Reconstituted Complex physical 18221373 PAK3 Reconstituted Complex physical 18541383 CDC42EP2 Reconstituted Complex physical 18541383 CDC42EP3 Reconstituted Complex physical 18541383 CDC42SE1 Reconstituted Complex physical 18541383 ARHGAP15 Reconstituted Complex physical 18541383 ADAP2 Reconstituted Complex physical 18541383 CTNND1 Reconstituted Complex physical 18541383 EPB49 Reconstituted Complex physical 18541383 GABARAPL1 Reconstituted Complex physical 18541383 KIAA1191 Reconstituted Complex physical 18541383 RNF10 Reconstituted Complex physical 18541383 MEF2D Reconstituted Complex physical 18541383 IARS Reconstituted Complex physical 18541383 VDAC1 Affinity Capture-Western physical 18614564 VDAC2 Affinity Capture-Western physical 18614564 NDUFB6 Affinity Capture-Western physical 18614564 SPTBN1 Affinity Capture-Western physical 18614564 CLTC Affinity Capture-Western physical 18614564 AP1B1 Affinity Capture-Western physical 18614564 UQCRC2 Affinity Capture-Western physical 18614564 SNCAIP Reconstituted Complex physical 19762560 SNCAIP Co-crystal Structure physical 19762560 HSPA1A FRET physical 19875982 HSPA1A Reconstituted Complex physical 19875982 LRRK2 Affinity Capture-Western physical 19878656 LRRK2 Affinity Capture-Western physical 19878656 SNCAIP Affinity Capture-Western physical 15944382 SNCAIP Affinity Capture-Western physical 15944382 SIAH2 Biochemical Activity physical 15064394 UBC Affinity Capture-Western physical 10973942 UBC FRET physical 11603807 VDAC1 Biochemical Activity physical 20098416 HERPUD1 Affinity Capture-Western physical 20604806 HERPUD1 Affinity Capture-Western physical 20604806 TRAF6 Affinity Capture-Western physical 20634198 UBC Affinity Capture-Western physical 20634198 SIAH1 Reconstituted Complex physical 18065497 SIAH1 Affinity Capture-Western physical 18065497 UBC Affinity Capture-Western physical 18065497 SIAH1 Biochemical Activity physical 18070888 SIAH2 Biochemical Activity physical 18070888 UBC Reconstituted Complex physical 18070888 SIAH1 Affinity Capture-Western physical 18070888 SIAH2 Affinity Capture-Western physical 18070888 UBC Affinity Capture-Western physical 18070888 NEDD4 Biochemical Activity physical 21953697 NEDD4 Affinity Capture-Western physical 21953697 UBC Affinity Capture-Western physical 21953697 SIAH1 Reconstituted Complex physical 19224863 SIAH1 Affinity Capture-Western physical 19224863 UBC Affinity Capture-Western physical 19224863 UBC Reconstituted Complex physical 19224863 SIAH1 Biochemical Activity physical 19224863 SIAH2 Biochemical Activity physical 19224863 SIAH1 Affinity Capture-Western physical 19224863 PDE4DIP Two-hybrid physical 21900206 APLP1 Two-hybrid physical 21900206 DOCK7 Two-hybrid physical 21900206 GAPDH Two-hybrid physical 21900206 CDK4 Two-hybrid physical 21900206 A1BG Two-hybrid physical 21900206 EEF1A1 Two-hybrid physical 21900206 EIF3G Two-hybrid physical 21900206 SDF4 Two-hybrid physical 21900206 UBC Affinity Capture-MS physical 15852347 USP9X Affinity Capture-Western physical 22065755 USP9X Affinity Capture-Western physical 22065755 SIAH2 Biochemical Activity physical 22065755 SUMO2 Reconstituted Complex physical 21746851 SUMO2 Affinity Capture-Western physical 21746851 SNCA PCA physical 21358815 UBC Affinity Capture-Western physical 21358815 STUB1 Biochemical Activity physical 21358815 UBC Reconstituted Complex physical 21358815 STUB1 Affinity Capture-Western physical 21358815 HSPA4 Affinity Capture-Western physical 21358815 BAG5 Affinity Capture-Western physical 21358815 BAG5 Reconstituted Complex physical 21358815 CBX4 Affinity Capture-Western physical 21256122