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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TIMP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7076 Official gene symbol TIMP1 Full name TIMP metallopeptidase inhibitor 1 Aliases ,CLGI,EPA,EPO,FLJ90373,HCI,TIMP, Gene summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq] Location Chromosome: X   Locus: Xp11.3-p11.23 Gene position 47441690 - 47446190  Map Viewer Gene orientation plus Gene size 4501 bp Gene sequence >TIMP1:10293434..10297934:Length=4501 TTTCGTCGGCCCGCCCCTTGGCTTCTGCACTGATGGTGGGTGGATGAGTAATGCATCCAG GAAGCCTGGAGGCCTGTGGTTTCCGCACCCGCTGCCACCCCCGCCCCTAGCGTGGACATT TATCCTCTAGCGCTCAGGCCCTGCCGCCATCGCCGCAGATCCAGCGCCCAGAGAGACACC AGAGGTAAGCAGGGCCCGGGGTGGCCCAGCAGGGACCGGAGCTGGGCTGCAGCTTGGGTG CTGGCCACCAGGCCCGTGCACTCCCGTGCCAGATGCCTGTCTACTCAGCTTGGCCTGCGG GTACCAGGACCCTGGGCTAGTCTAGGGGGAAGAGGGTCGGAGGCTGGAACTGCTTTCCCA ACCCCGAGGCTCCAAACTCCCTAGAACCCCTGACATCCGCCCCCAATTCCCCCAAACCCA TGACCCCCTAATATCACAAATGCTTTCCAAATCCCCCCGCAAATTCCTTCATCCCGAAAT TTCCCTCATCGCCCCCTAAATACCCACCGCTAACCCCTGCAGCTCCCTAAACTCCCCCAG CTCCCCAATCCCCAGTTCCCCAGCTCCCAAACTTCTTTTGCCCTCAAATTCCTCAAGTAT CCCCATTGCCTTAAGCCCCCAAATTCCCCCAACCCCTTCAACCTCCAAACTCCCCCAGCT CCCTAAACCCCCAACCTCCTCCAAATTCCTCAACCTCCCTAAATTCCCCCAGCCTCTTAT ATCTCTTAATATACACAACCCCTAAACTCTGCCGTCTCCAAACTCCTCCAGCCCCCAATC CCAAATTCCTCACCCCCAAACTCCTCAACCTCCAGAATTCCCCAATCCCCTCATTCCTCA AACTTCCTCAGCCCCCTTCTCCCCCAAGTGCCACAACCCCATAACCCCGCAACTCACTCA GTCCCTCAATAATTTAAACTCTCCCAACTCTCTAAACCCTAAATTCCTCTGCGCTCCCCA ATCCCCTTAAAATCCCTAAGCTTACCAACCCCTCAAGCCCAAATCCAGCCCCCTAATCCC CCCCATAGGCTGCCCCGGGGCAAGATGGGGTGGATGACCTGCCCAGGTCAGCAGATCAGC TGGGCCGGGGCCTGCCTGACATCCCCCTTCCCCACAGAACCCACCATGGCCCCCTTTGAG CCCCTGGCTTCTGGCATCCTGTTGTTGCTGTGGCTGATAGCCCCCAGCAGGGCCTGCACC TGTGTCCCACCCCACCCACAGACGGCCTTCTGCAATTCCGACCTCGGTGAGTCCTCACCC CACTCAGCCCACACACTCTGCCTTGGTTTCCCTTTCAGTCCAGTGGGGCTCACCATGGCA CTTACCTCTAGAATGATTCCACTCGCCCCTGCACTTCCTCTGCTTTAGCCACACTGGCAT CCTCACACTTCCTTGAGTACTCTGTGCCCAAGCCCACCACAGGATCTGCATGCTGGCTGC TCCCTCTGCCTGGTACACTTTCCCCCCAGGTATCCACATGGGTGGCTGCCTCAAACGTCA CCTTCTCAGGATGGCCTTCCCTGGCCATCCTGTTTAAAATTTTAACCCCTGCCCCTTAGT ACTCCTGATCTCCTGTTAAACAGAAAAATATTCAGTGATACTTGTTATAACACAGTAAGG AAGACCATATTCAGGACCATGGTGATGGGTATAGGAACCACTGCAATGGGATCTTGCAGT CGGTGGGAGAGATTGGGCTCAACACTGAATATAGCATGGGCCAGTGGGAATGTGTAGCTA AGGAGCAGTGTGAGGGTCTGTGGGTGGAAATTACTAAGAAGAAACATCAGGGGTAAGGGG GATTCTGGCTAAACCGACGTAACAGGATTCTTGCTGAAGGCAGGCCAAGGGGAATCAGAC ATCACCTGGGGGATGGTGGAAGATGAAGAACCCAGTCAGATAGCAAGGATGATCAGGTAT TGAGGATGATCAGAGATTGAGGATGATCAGAGATTGAGGATGATCAGGTATTGAGGATGA TCAGAGATTGAGGATGATCAGGTATTGAGGATGATCAGAGATTGAGGATGATCAGGTATT GAGGATGATCAGAGATTGAGGATGATCAGATATAGAATATAGGGGTTCTTGCTAAACTGA CTTAGCAAGGCTCTCGGCTAAAACTGGATTTTACAAGGAAGTGCACAGATGGGCCTAGGA GGAGGTTCAGGAGCCTGAGTAAAGTTTGGTCAAGCAAAGAATCTTTGTCAGCCCCTTACC CAGGTCTGTAATTCCCCATTATACTTAATGTCTAACATTCCATATCCTTATTTTGTTTGT TCTTAGCCTGTCTCCTCCTGGCTAGAATGTGAACTCCACAAGGAAAGGGATTTCTGTGTT TTGTTCACTGTTGTGTCCCTAACACCCAGAACAATGTCTGGCACACAGTGGGCACTCCCA AATATTTGAGGAGTAAATGAACAAATCAATGTATGAAAATGGCTTAAGCAGTGCCCGGCA AAGAGAGACACTCAACATACAGATGAATCAATGAACAAATGTGTAAATCACTTTGTGTGC TGTCTGGCATCCAATAACCCCTATTTATGTATGCGCTTTGCTGGTATGATGATGATGATG ATGATGATCTTATTTTTATTGGCTCATGCAGTCCATTTGACTCATATTTCCCTCCTCTCC TGCAGTCATCAGGGCCAAGTTCGTGGGGACACCAGAAGTCAACCAGACCACCTTATACCA GCGTTATGAGATCAAGATGACCAAGGTATCCCCTGCCCCCGCCTCTTTCCCAGCATTTTC TAACATCTTCCTCCTGGTCAAAACAGAAACTTCTGGCCACTGGTTGGTGCGAGAAAGTTG GCTGTGATCTTGGGATGCTATATGACTTCAGGGAAGAACCTGGAGTGGGAGGATTATGTC AGTAAAAGAGACACTTCCCCTCATCCATCAACAGATGTATAAAGGGTTCCAAGCCTTAGG GGATGCCGCTGACATCCGGTTCGTCTACACCCCCGCCATGGAGAGTGTCTGCGGATACTT CCACAGGTCCCACAACCGCAGCGAGGAGTTTCTCATTGCTGGTGAGGCACCGTCCCCGCG CCCTGTGCCACACCAACCAGTCCCTGGGGCGCGGCCTAGCAACCACGAGGGGGCGAGGCT CTGATGGGAATGGTCCCACTGGAAATGGGGACCACCCCAATTTCAGTCTATCAGAAGGCC GGGCCTTTGGCAGCTTGGCAGCTCAGCCAATCACAAGCTGCTTGTCGGTCCCCGCCCCGC CTTTCTCCTTAGGAAAACTGCAGGATGGACTCTTGCACATCACTACCTGCAGTTTTGTGG CTCCCTGGAACAGCCTGAGCTTAGCTCAGCGCCGGGGCTTCACCAAGACCTACACTGTTG GCTGTGAGGAATGCACAGTGAGTGCCTGGACCCTGACCTCCAACGGGAGATCCTTCCCGG GGCCATTCCCTAAATCGTGGGCTTGTTTCTTGCTCCCTCTGGCTATTCTGTGTCCCTGTG GCTGCTCCCCAACCCTAAGGGCTGTCCCTGATCTCTCTTGCTATTTCCCCAAGCCCGAGA CTGCTCCCTTACAAATTCTGGCTGCTCCCTTTCCCTGTGTCCAATACCGTGTGATCACCT GTCCCTCCCTGGTCCCTCTAATTCTCCCTTGTGACTATTCTGTAATCCCACTCCCCGTTC CTGAGCCCCCGGGATTGTTTCTTGGTTCCCCAGAATGTTCTCCAAGAACCCAAAGTGCTG TTCCCTAATCCCACTGACCCTTCCTCAGCACATCTGCTTGTTGCTCTGCAGCTCTGACTA TTCCAGACACCAGAGGGTGTTACACTGACCTCCTGGCTAGTCCAAGCCTGTTCCCTGATG GCTCCTGATGGCCTCTGAGCCCAGTGACTATCTTGAAGCCCCACTGGCTATTCCTGTGCT TAAACTCCTTAGCCGCCAACCGGGTGGGGCCCCTTACTACTGCCAGTTTTTCCCTGTCCT TTGGGACAATTCCACAGGCGACCTGCCTGACTGACCCCCAGGGCCTATTCCCCAGCCACC ATTCCAGGACACTGATTTACTGGCTTACTGTTACCTTTCAGGACCCAGTGACATTTCCCT CAATGGGAGGGGCTGTCCTGGGGTATGTACTTAGGTGGGGTGAGAGCAAGTCTCCCCAGC GGCTCAGTGTTGAAAGCTGAGGAGAGGAAGTTCTGCTCCACGGGGGAGGCAGGGAGAAGC CCTCAGAGATGTTTCCCTCCTCCCTTCCAGGTGTTTCCCTGTTTATCCATCCCCTGCAAA CTGCAGAGTGGCACTCATTGCTTGTGGACGGACCAGCTCCTCCAAGGCTCTGAAAAGGGC TTCCAGTCCCGTCACCTTGCCTGCCTGCCTCGGGAGCCAGGGCTGTGCACCTGGCAGTCC CTGCGGTCCCAGATAGCCTGAATCCTGCCCGGAGTGGAAGCTGAAGCCTGCACAGTGTCC ACCCTGTTCCCACTCCCATCTTTCTTCCGGACAATGAAATAAAGAGTTACCACCCAGCAG A OMIM ID 305370