Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TPM1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7168
Official gene symbolTPM1
Full nametropomyosin 1 (alpha)
Aliases,C15orf13,CMD1Y,HTM-alpha,TMSA,
Gene summaryThis gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq]
LocationChromosome: 15   Locus: 15q22.1
Gene position63334838 - 63364114  Map Viewer
Gene orientationplus
Gene size29277 bp
Gene sequence
OMIM ID191010