Entrez gene ID | | 7321 |
Official gene symbol | | UBE2D1 |
Full name | | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) |
Aliases | | ,E2(17)KB1,SFT,UBC4/5,UBCH5,UBCH5A, |
Gene summary | | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q11.2-q21 |
Gene position | | 60094739 - 60130509 Map Viewer |
Gene orientation | | plus |
Gene size | | 35771 bp |
Gene sequence |
| |
OMIM ID | | 602961 |
|