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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for WRN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7486
Official gene symbolWRN
Full nameWerner syndrome, RecQ helicase-like
Aliases,DKFZp686C2056,RECQ3,RECQL2,RECQL3,
Gene summaryThis gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq]
LocationChromosome: 8   Locus: 8p12-p11.2
Gene position30890778 - 31031277  Map Viewer
Gene orientationplus
Gene size140500 bp
Gene sequence
OMIM ID604611