Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for WRN (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000723 telomere maintenance IMP GO:0000731 DNA synthesis involved in DNA repair IDA GO:0001302 replicative cell aging IEA GO:0006139 nucleobase-containing compound metabolic process IEA GO:0006200 ATP catabolic process IDA GO:0006259 DNA metabolic process IDA GO:0006260 DNA replication IMP GO:0006284 base-excision repair IDA GO:0006310 DNA recombination IEA GO:0006974 response to DNA damage stimulus IDA GO:0006979 response to oxidative stress IDA GO:0007568 aging NAS GO:0007569 cell aging IMP GO:0009267 cellular response to starvation IDA GO:0010225 response to UV-C IDA GO:0010259 multicellular organismal aging IMP GO:0031297 replication fork processing IDA GO:0031297 replication fork processing IMP GO:0032066 nucleolus to nucleoplasm transport IDA GO:0040009 regulation of growth rate IEA GO:0042981 regulation of apoptosis IGI GO:0044237 cellular metabolic process IEA GO:0051345 positive regulation of hydrolase activity IDA cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005654 nucleoplasm IDA GO:0005730 nucleolus IDA GO:0005813 centrosome IDA GO:0032389 MutLalpha complex IDA molecular_function GO:0000166 nucleotide binding IEA GO:0000287 magnesium ion binding IDA GO:0000403 Y-form DNA binding IDA GO:0000405 bubble DNA binding IDA GO:0003677 DNA binding IDA GO:0003678 DNA helicase activity IDA GO:0003678 DNA helicase activity IMP GO:0004003 ATP-dependent DNA helicase activity IDA GO:0004386 helicase activity IDA GO:0004527 exonuclease activity IDA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008408 3'-5' exonuclease activity IDA GO:0009378 four-way junction helicase activity IDA GO:0016887 ATPase activity IDA GO:0030145 manganese ion binding IDA GO:0032403 protein complex binding IDA GO:0042803 protein homodimerization activity IDA GO:0043138 3'-5' DNA helicase activity IDA GO:0043140 ATP-dependent 3'-5' DNA helicase activity IEA GO:0051880 G-quadruplex DNA binding IDA

Protein-protein interaction details for WRN (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MDC1 Protein-peptide physical 14578343 TERF2 Affinity Capture-Western physical 12181313 TERF2 Reconstituted Complex physical 12181313 BLM Affinity Capture-Western physical 11919194 BLM Reconstituted Complex physical 11919194 ATM Protein-peptide physical 10608806 ATR Protein-peptide physical 10608806 PRKDC Protein-peptide physical 10608806 FEN1 Reconstituted Complex physical 14688284 TERF2 Affinity Capture-Western physical 12181313 TERF2 Co-localization physical 12181313 TERF2 Reconstituted Complex physical 12181313 PCNA Affinity Capture-Western physical 12633936 PCNA Affinity Capture-Western physical 12633936 PRKDC Affinity Capture-Western physical 11889123 PRKDC Biochemical Activity physical 11889123 WRNIP1 Two-hybrid physical 11301316 WRNIP1 Affinity Capture-Western physical 11301316 WRNIP1 Reconstituted Complex physical 11301316 WRNIP1 Affinity Capture-Western physical 11301316 POLR1C Affinity Capture-Western physical 11971179 XRCC5 Affinity Capture-Western physical 12177300 XRCC6 Affinity Capture-Western physical 12177300 XRCC5 Reconstituted Complex physical 12177300 XRCC6 Reconstituted Complex physical 12177300 TP53 Affinity Capture-Western physical 12080066 TP53 Reconstituted Complex physical 12080066 XRCC6 Affinity Capture-Western physical 10880505 XRCC5 Affinity Capture-Western physical 10880505 TP53 Reconstituted Complex physical 11427532 PCNA Reconstituted Complex physical 10871373 FEN1 Affinity Capture-Western physical 11598021 FEN1 Reconstituted Complex physical 11598021 TERF2 Affinity Capture-Western physical 18212065 WDR48 Affinity Capture-MS physical 19615732 CHAF1A Far Western physical 17173071 CHAF1A Far Western physical 17173071 POLB Far Western physical 17173071 CHAF1A Co-localization physical 17173071 CHAF1A Affinity Capture-Western physical 17173071 CHAF1A Affinity Capture-Western physical 17173071 POT1 Phenotypic Enhancement genetic 21098121 FEN1 Reconstituted Complex physical 16326861 FEN1 Affinity Capture-Luminescence physical 16326861 H2AFX Affinity Capture-Western physical 15733840 NBN Affinity Capture-Western physical 15733840 H2AFX Reconstituted Complex physical 15733840 DHX9 Reconstituted Complex physical 17498979 RAD51 Affinity Capture-Western physical 17118963 RAD51 Affinity Capture-Western physical 17118963 ATR Affinity Capture-Western physical 17118963 RAD51 Reconstituted Complex physical 17118963 RAD52 Reconstituted Complex physical 17118963 RAD51 Reconstituted Complex physical 17118963 RAD52 Reconstituted Complex physical 17118963 RAD52 Far Western physical 17118963 RAD51 Far Western physical 17118963 ATRX Far Western physical 17118963 RAD54B Far Western physical 17118963 NBN Affinity Capture-Western physical 20600238 NBN Affinity Capture-Western physical 20600238 PCNA Affinity Capture-Western physical 20600238 SIRT1 Affinity Capture-Western physical 19343720 SIRT1 Affinity Capture-MS physical 19343720 SUMO1 Reconstituted Complex physical 19596686 WRN Reconstituted Complex physical 10783163 XRCC6 Reconstituted Complex physical 10783163 XRCC5 Reconstituted Complex physical 10783163 XRCC6 Affinity Capture-Western physical 10783163 XRCC5 Affinity Capture-Western physical 10783163 XRCC6 Affinity Capture-Western physical 10783163 XRCC5 Affinity Capture-Western physical 10783163 XRCC5 Affinity Capture-Western physical 11328876