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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for WT1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7490
Official gene symbolWT1
Full nameWilms tumor 1
Aliases,AWT1,GUD,WAGR,WIT-2,WT33,
Gene summaryThis gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p13
Gene position32457087 - 32409325  Map Viewer
Gene orientationminus
Gene size47763 bp
Gene sequence
OMIM ID607102