| Entrez gene ID | | 7518 |
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| Official gene symbol | | XRCC4 |
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| Full name | | X-ray repair complementing defective repair in Chinese hamster cells 4 |
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| Aliases | | ,-, |
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| Gene summary | | The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq] |
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| Location | | Chromosome: 5 Locus: 5q13-q14 |
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| Gene position | | 82373317 - 82649579 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 276263 bp |
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| Gene sequence |
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