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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for XRCC4 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001701 in utero embryonic development IEA GO:0002328 pro-B cell differentiation IEA GO:0006281 DNA repair TAS GO:0006302 double-strand break repair IDA GO:0006302 double-strand break repair IEA GO:0006302 double-strand break repair TAS GO:0006303 double-strand break repair via nonhomologous end joining IDA GO:0006303 double-strand break repair via nonhomologous end joining IMP GO:0006303 double-strand break repair via nonhomologous end joining NAS GO:0006303 double-strand break repair via nonhomologous end joining TAS GO:0006310 DNA recombination IEA GO:0007417 central nervous system development IEA GO:0010165 response to X-ray IDA GO:0010332 response to gamma radiation IEA GO:0016032 viral reproduction TAS GO:0019047 provirus integration TAS GO:0019059 initiation of viral infection TAS GO:0033077 T cell differentiation in thymus IEA GO:0033152 immunoglobulin V(D)J recombination IEA GO:0043524 negative regulation of neuron apoptosis IEA GO:0045190 isotype switching IEA GO:0048146 positive regulation of fibroblast proliferation IEA GO:0050769 positive regulation of neurogenesis IEA GO:0051103 DNA ligation involved in DNA repair IDA GO:0051351 positive regulation of ligase activity IDA GO:0071285 cellular response to lithium ion IEA cellular_component GO:0000793 condensed chromosome IDA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005634 nucleus NAS GO:0005654 nucleoplasm TAS GO:0005829 cytosol IDA GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IDA GO:0032807 DNA ligase IV complex IDA GO:0070419 nonhomologous end joining complex IDA molecular_function GO:0003677 DNA binding IDA GO:0003677 DNA binding IEA GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IPI GO:0016874 ligase activity IDA

Protein-protein interaction details for XRCC4 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID IFFO1 Two-hybrid physical 16189514 ACTN1 Two-hybrid physical 16189514 NHEJ1 Two-hybrid physical 17567543 XRCC4 Two-hybrid physical 17567543 NHEJ1 Two-hybrid physical 17567543 NHEJ1 Affinity Capture-Western physical 17567543 LIG4 Two-hybrid physical 17567543 LIG4 Affinity Capture-Western physical 17567543 PNKP Affinity Capture-MS physical 17353931 C9orf82 Two-hybrid physical 16169070 CHD3 Two-hybrid physical 16169070 VIM Two-hybrid physical 16169070 XRCC4 Two-hybrid physical 16169070 LIG4 Co-crystal Structure physical 11702069 NBN Two-hybrid physical 18458108 UBC Affinity Capture-Western physical 16412978 SETMAR Affinity Capture-Western physical 18773976 PRKDC Affinity Capture-Western physical 15520013 LIG4 Affinity Capture-Western physical 15520013 XRCC6 Affinity Capture-Western physical 15520013 XRCC5 Affinity Capture-Western physical 15520013 XRCC6 Affinity Capture-Western physical 15520013 XRCC5 Affinity Capture-Western physical 15520013 CALM1 Reconstituted Complex physical 15840729 LIG4 Reconstituted Complex physical 11809878