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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CASP3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID836
Official gene symbolCASP3
Full namecaspase 3, apoptosis-related cysteine peptidase
Aliases,CPP32,CPP32B,SCA-1,
Gene summaryThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q34
Gene position185570629 - 185548850  Map Viewer
Gene orientationminus
Gene size21780 bp
Gene sequence
OMIM ID600636