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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CASP3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001782 B cell homeostasis IEA GO:0001836 release of cytochrome c from mitochondria IEA GO:0006309 DNA fragmentation involved in apoptotic nuclear change IEA GO:0006309 DNA fragmentation involved in apoptotic nuclear change TAS GO:0006508 proteolysis IDA GO:0006508 proteolysis IEA GO:0006915 apoptosis IEA GO:0006915 apoptosis TAS GO:0006917 induction of apoptosis IEA GO:0006917 induction of apoptosis TAS GO:0006921 cellular component disassembly involved in apoptosis TAS GO:0006974 response to DNA damage stimulus IEA GO:0007507 heart development IEA GO:0007605 sensory perception of sound IEA GO:0008624 induction of apoptosis by extracellular signals TAS GO:0008625 induction of apoptosis via death domain receptors IEA GO:0008629 induction of apoptosis by intracellular signals TAS GO:0008631 induction of apoptosis by oxidative stress IEA GO:0008635 activation of caspase activity by cytochrome c TAS GO:0009411 response to UV IEA GO:0009611 response to wounding IEA GO:0030216 keratinocyte differentiation IEA GO:0030264 nuclear fragmentation involved in apoptotic nuclear change IMP GO:0030889 negative regulation of B cell proliferation IEA GO:0034612 response to tumor necrosis factor TAS GO:0042981 regulation of apoptosis TAS GO:0043029 T cell homeostasis IEA GO:0043066 negative regulation of apoptosis IGI GO:0043525 positive regulation of neuron apoptosis IEA GO:0045165 cell fate commitment IEA GO:0045736 negative regulation of cyclin-dependent protein kinase activity IEA GO:0046007 negative regulation of activated T cell proliferation IEA GO:0048011 nerve growth factor receptor signaling pathway TAS cellular_component GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IDA GO:0005829 cytosol IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS molecular_function GO:0004190 aspartic-type endopeptidase activity IEA GO:0004197 cysteine-type endopeptidase activity IEA GO:0004197 cysteine-type endopeptidase activity TAS GO:0004861 cyclin-dependent protein kinase inhibitor activity IEA GO:0005515 protein binding IPI GO:0008233 peptidase activity IDA GO:0008233 peptidase activity IEA

Protein-protein interaction details for CASP3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BCL2 Biochemical Activity physical 11752215 BLM Biochemical Activity physical 11470874 MCL1 Biochemical Activity physical 15637055 TRAF3 Biochemical Activity physical 11261798 HCLS1 Biochemical Activity physical 11988074 CFLAR Affinity Capture-Western physical 9208847 DCC Two-hybrid physical 11248093 DCC Affinity Capture-Western physical 11248093 TRAF3 Biochemical Activity physical 11098060 CASP2 Biochemical Activity physical 11399776 BID Biochemical Activity physical 11399776 PARG Biochemical Activity physical 11053413 XIAP Affinity Capture-Western physical 11447297 XIAP Reconstituted Complex physical 11447297 XIAP Affinity Capture-Western physical 11927604 BIRC7 Reconstituted Complex physical 11024045 GORASP1 Biochemical Activity physical 11815631 SREBF2 Biochemical Activity physical 8605870 BIRC5 Reconstituted Complex physical 9850056 CASP6 Biochemical Activity physical 8900201 CTTN Biochemical Activity physical 11689006 HCLS1 Biochemical Activity physical 11689006 DBNL Biochemical Activity physical 11689006 BMX Biochemical Activity physical 11278797 HSPD1 Affinity Capture-Western physical 10205158 HSPD1 Affinity Capture-Western physical 10205158 HSPE1 Affinity Capture-Western physical 10205158 CFLAR Reconstituted Complex physical 9326610 CFLAR Two-hybrid physical 9326610 CASP3 Co-crystal Structure physical 11257232 XIAP Co-crystal Structure physical 11257232 XIAP Reconstituted Complex physical 11257232 CASP8 Biochemical Activity physical 11832478 USO1 Biochemical Activity physical 12438416 MAP3K14 Affinity Capture-Western physical 11002417 BIRC3 Reconstituted Complex physical 9384571 BIRC2 Reconstituted Complex physical 9384571 XIAP Reconstituted Complex physical 9384571 CASP8 Biochemical Activity physical 8962078 CASP10 Biochemical Activity physical 8962078 BIRC5 Biochemical Activity physical 11170436 BIRC5 Reconstituted Complex physical 11170436 XIAP Reconstituted Complex physical 9230442 XIAP Reconstituted Complex physical 9230442 XIAP Reconstituted Complex physical 11359776 GRIPAP1 Biochemical Activity physical 10896157 HSPD1 Affinity Capture-Western physical 10205159 NDUFS1 Biochemical Activity physical 15186778 RNF2 Biochemical Activity physical 17379327 GMNN Biochemical Activity physical 17261582 HEY2 Affinity Capture-Western physical 17217622 RBX1 Affinity Capture-Western physical 17217622 FBXW11 Affinity Capture-Western physical 17217622 BTRC Affinity Capture-Western physical 17217622 BIRC2 Reconstituted Complex physical 19258326 UBC Reconstituted Complex physical 19258326 BIRC2 Biochemical Activity physical 19258326 THAP11 Two-hybrid physical 18585351