Entrez gene ID | | 84433 |
Official gene symbol | | CARD11 |
Full name | | caspase recruitment domain family, member 11 |
Aliases | | ,BIMP3,CARMA1,MGC133069, |
Gene summary | | The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7p22 |
Gene position | | 3083579 - 2945769 Map Viewer |
Gene orientation | | minus |
Gene size | | 137811 bp |
Gene sequence |
| |
OMIM ID | | 607210 |
|