Entrez gene ID | | 864 |
Official gene symbol | | RUNX3 |
Full name | | runt-related transcription factor 3 |
Aliases | | ,AML2,CBFA3,FLJ34510,MGC16070,PEBP2aC, |
Gene summary | | This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p36 |
Gene position | | 25291501 - 25226002 Map Viewer |
Gene orientation | | minus |
Gene size | | 65500 bp |
Gene sequence |
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OMIM ID | | 600210 |