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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SOCS1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8651 Official gene symbol SOCS1 Full name suppressor of cytokine signaling 1 Aliases ,CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3, Gene summary This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq] Location Chromosome: 16   Locus: 16p13.13 Gene position 11350039 - 11348274  Map Viewer Gene orientation minus Gene size 1766 bp Gene sequence >SOCS1:complement(11288274..11290039):Length=1766 GGCAGCTGCACGGCTCCTGGCCCCGGAGCATGCGCGAGAGCCGCCCCGGAGCGCCCCGGA GCCCCCCGCCGTCCCGCCCGCGGCGTCCCGCGCCCCGCCGCCAGGTGAGCCGGGCCCTGG GCGAGGAGGCGGGAGGGAGGAGGGAGGGGAGTCCAGGGCAGCCAGGAGTCGGGCGAGCCT CGGGGGCTGCAGAATGGGGTCGCGGCCGCGATGCCCCTGACCCTCGCCGGCCCCACCCAG GCCGCCCCCCGCGCGCGGGGCTCCCGCAGCACAGCCTTTCTCCGGCCCTAGCCCAAATCG CCCAGACCAGGCGCGGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAGCCG GGGCCGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCTCGGTGCTGCCCG GAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGAGCTCCGCGGAGTACAG AGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAACGGATCCGCGCGGACTTGGTGCTCCG TGCTCGCCCCCTAGGGCCGGGTCCGCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGC GCACACCTGCCCGGCCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACC CCCGGACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCACACAACC AGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACGGCGGCCAGAACCTT CCTCCTCTTCCTCCTCCTCGCCCGCGGCCCCCGCGCGCCCGCGGCCGTGCCCCGCGGTCC CGGCCCCGGCCCCCGGCGACACGCACTTCCGCACATTCCGTTCGCACGCCGATTACCGGC GCATCACGCGCGCCAGCGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCG TGCACGGGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGACA GCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGGACCCACGAGCA TCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATGGCAGCCGCGAGAGCTTCGACT GCCTCTTCGAGCTGCTGGAGCACTACGTGGCGGCGCCGCGCCGCATGCTGGGGGCCCCGC TGCGCCAGCGCCGCGTGCGGCCGCTGCAGGAGCTGTGCCGCCAGCGCATCGTGGCCACCG TGGGCCGCGAGAACCTGGCTCGCATCCCCCTCAACCCCGTCCTCCGCGACTACCTGAGCT CCTTCCCCTTCCAGATTTGACCGGCAGCGCCCGCCGTGCACGCAGCATTAACTGGGATGC CGTGTTATTTTGTTATTACTTGCCTGGAACCATGTGGGTACCCTCCCCGGCCTGGGTTGG AGGGAGCGGATGGGTGTAGGGGCGAGGCGCCTCCCGCCCTCGGCTGGAGACGAGGCCGCA GACCCCTTCTCACCTCTTGAGGGGGTCCTCCCCCTCCTGGTGCTCCCTCTGGGTCCCCCT GGTTGTTGTAGCAGCTTAACTGTATCTGGAGCCAGGACCTGAACTCGCACCTCCTACCTC TTCATGTTTACATATACCCAGTATCTTTGCACAAACCAGGGGTTGGGGGAGGGTCTCTGG CTTTATTTTTCTGCTGTGCAGAATCCTATTTTATATTTTTTAAAGTCAGTTTAGGTAATA AACTTTATTATGAAAGTTTTTTTTTT OMIM ID 603597