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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SOCS1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001932 regulation of protein phosphorylation ISS GO:0007259 JAK-STAT cascade TAS GO:0019221 cytokine-mediated signaling pathway ISS GO:0019221 cytokine-mediated signaling pathway TAS GO:0031100 organ regeneration IEA GO:0032355 response to estradiol stimulus IEA GO:0032496 response to lipopolysaccharide IEA GO:0032570 response to progesterone stimulus IEA GO:0034097 response to cytokine stimulus IEA GO:0035556 intracellular signal transduction IEA GO:0040008 regulation of growth IEA GO:0042493 response to drug IEA GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein ISS GO:0043434 response to peptide hormone stimulus IEA GO:0045444 fat cell differentiation IEA GO:0046426 negative regulation of JAK-STAT cascade ISS GO:0046426 negative regulation of JAK-STAT cascade NAS GO:0046627 negative regulation of insulin receptor signaling pathway ISS GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:0060337 type I interferon-mediated signaling pathway TAS GO:0060338 regulation of type I interferon-mediated signaling pathway TAS GO:0071230 cellular response to amino acid stimulus IEA cellular_component GO:0005737 cytoplasm TAS GO:0005829 cytosol TAS molecular_function GO:0004860 protein kinase inhibitor activity TAS GO:0005159 insulin-like growth factor receptor binding IPI GO:0005515 protein binding IPI GO:0019210 kinase inhibitor activity ISS GO:0019901 protein kinase binding IPI

Protein-protein interaction details for SOCS1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID IGF1R Two-hybrid physical 9727029 JAK2 Two-hybrid physical 10064597 CSF1R Two-hybrid physical 11297560 IRS2 Affinity Capture-Western physical 12228220 IRS1 Affinity Capture-Western physical 12228220 IRS2 Affinity Capture-Western physical 12228220 JAK2 Affinity Capture-Western physical 11713228 KIT Two-hybrid physical 10022833 KIT Affinity Capture-Western physical 10022833 FLT3 Affinity Capture-Western physical 10022833 VAV1 Affinity Capture-Western physical 10022833 VAV2 Affinity Capture-Western physical 10022833 GRB2 Reconstituted Complex physical 10022833 CRK Reconstituted Complex physical 10022833 NCK1 Reconstituted Complex physical 10022833 FYN Reconstituted Complex physical 10022833 ITK Reconstituted Complex physical 10022833 GHR Affinity Capture-Western physical 10585430 GHR Reconstituted Complex physical 10585430 JAK2 Two-hybrid physical 9202126 JAK2 Reconstituted Complex physical 9202126 JAK2 Affinity Capture-Western physical 9202126 MPL Affinity Capture-Western physical 10517496 TCEB1 Affinity Capture-Western physical 10051596 TCEB3 Affinity Capture-Western physical 10051596 TEC Reconstituted Complex physical 9341160 TEC Two-hybrid physical 9341160 IL2RB Affinity Capture-Western physical 11133764 JAK2 Reconstituted Complex physical 10064597 JAK2 Affinity Capture-Western physical 10064597 CSF1R Affinity Capture-Western physical 11297560 CSF1R Reconstituted Complex physical 11297560 JAK2 Affinity Capture-Western physical 10455112 EGFR Affinity Capture-Western physical 12070153 JAK2 Affinity Capture-Western physical 11971965 JAK2 Reconstituted Complex physical 9344848 SOCS2 Affinity Capture-Western physical 17898043 UBC Affinity Capture-Western physical 17898043 COMMD1 Affinity Capture-Western physical 17183367 COMMD1 Reconstituted Complex physical 17183367 RELA Reconstituted Complex physical 17183367 RELA Reconstituted Complex physical 17183367 ALK Affinity Capture-MS physical 14968112 MAP3K5 Affinity Capture-Western physical 16407264 MAP3K5 Affinity Capture-Western physical 16407264 MAP3K5 Reconstituted Complex physical 16407264 TCEB2 Affinity Capture-Western physical 21119685 TCEB1 Affinity Capture-Western physical 21119685 IRF3 Affinity Capture-Western physical 21079688 IRF3 Affinity Capture-Western physical 21079688 IFNAR1 Affinity Capture-Western physical 21757742 TYK2 Affinity Capture-Western physical 21757742 RELA Affinity Capture-Western physical 21084693 RELA Affinity Capture-Western physical 21084693