Entrez gene ID | | 8792 |
Official gene symbol | | TNFRSF11A |
Full name | | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
Aliases | | ,CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TRANCER, |
Gene summary | | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq] |
Location | | Chromosome: 18 Locus: 18q22.1 |
Gene position | | 59992548 - 60053504 Map Viewer |
Gene orientation | | plus |
Gene size | | 60957 bp |
Gene sequence |
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OMIM ID | | 603499 |
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