Entrez gene ID | | 8795 |
Official gene symbol | | TNFRSF10B |
Full name | | tumor necrosis factor receptor superfamily, member 10b |
Aliases | | ,CD262,DR5,KILLER,KILLER/DR5,TRAIL-R2,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9, |
Gene summary | | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8p22-p21 |
Gene position | | 22926700 - 22877646 Map Viewer |
Gene orientation | | minus |
Gene size | | 49055 bp |
Gene sequence |
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OMIM ID | | 603612 |
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