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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TNFRSF10B (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006915 apoptosis NAS GO:0006915 apoptosis TAS GO:0006919 activation of caspase activity NAS GO:0006919 activation of caspase activity TAS GO:0007165 signal transduction IEA GO:0007166 cell surface receptor linked signaling pathway TAS GO:0007250 activation of NF-kappaB-inducing kinase activity NAS GO:0008624 induction of apoptosis by extracellular signals TAS GO:0008625 induction of apoptosis via death domain receptors NAS GO:0008633 activation of pro-apoptotic gene products TAS GO:0042981 regulation of apoptosis NAS GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP GO:0071260 cellular response to mechanical stimulus IEP cellular_component GO:0005886 plasma membrane TAS GO:0016021 integral to membrane IC molecular_function GO:0004872 receptor activity IEA GO:0004872 receptor activity NAS GO:0005515 protein binding IPI GO:0008656 caspase activator activity NAS GO:0045569 TRAIL binding NAS

Protein-protein interaction details for TNFRSF10B (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BID Co-purification physical 15659383 EZR Co-purification physical 15659383 FADD Co-purification physical 15659383 FAS Co-purification physical 15659383 FASLG Co-purification physical 15659383 MAPK8 Co-purification physical 15659383 MSN Co-purification physical 15659383 CASP10 Co-purification physical 15659383 CASP8 Co-purification physical 15659383 RHOA Co-purification physical 15659383 ARHGDIA Co-purification physical 15659383 TNFRSF1A Co-purification physical 15659383 TIMM50 Two-hybrid physical 15044455 TNFSF10 Reconstituted Complex physical 11094155 CASP8 Affinity Capture-Western physical 9325248 CASP10 Affinity Capture-Western physical 9325248 CFLAR Affinity Capture-Western physical 9325248 TRADD Affinity Capture-Western physical 9430227 FADD Affinity Capture-Western physical 9430227 RIPK1 Affinity Capture-Western physical 9430227 TNFSF10 Affinity Capture-MS physical 9311998 TNFSF10 Co-crystal Structure physical 10549288 TNFSF10 Reconstituted Complex physical 10549288 CASP8 Affinity Capture-Western physical 11940602 CFLAR Affinity Capture-Western physical 11940602 FADD Affinity Capture-Western physical 11940602 UBC Affinity Capture-Western physical 19932172 CBL Affinity Capture-Western physical 19932172 ITCH Affinity Capture-Western physical 19808964 CFLAR Affinity Capture-Western physical 19343040 CASP8 Affinity Capture-Western physical 19343040 CASP8 Biochemical Activity physical 19343040