Entrez gene ID | | 8835 |
Official gene symbol | | SOCS2 |
Full name | | suppressor of cytokine signaling 2 |
Aliases | | ,CIS2,Cish2,SOCS-2,SSI-2,SSI2,STATI2, |
Gene summary | | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q |
Gene position | | 93963598 - 93969978 Map Viewer |
Gene orientation | | plus |
Gene size | | 6381 bp |
Gene sequence |
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OMIM ID | | 605117 |
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