Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HDAC3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8841
Official gene symbolHDAC3
Full namehistone deacetylase 3
Aliases,HD3,RPD3,RPD3-2,
Gene summaryHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q31
Gene position141016423 - 141000443  Map Viewer
Gene orientationminus
Gene size15981 bp
Gene sequence
OMIM ID605166