Entrez gene ID | | 8841 |
Official gene symbol | | HDAC3 |
Full name | | histone deacetylase 3 |
Aliases | | ,HD3,RPD3,RPD3-2, |
Gene summary | | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q31 |
Gene position | | 141016423 - 141000443 Map Viewer |
Gene orientation | | minus |
Gene size | | 15981 bp |
Gene sequence |
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OMIM ID | | 605166 |
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