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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HDAC3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0006476 protein deacetylation IDA GO:0006916 anti-apoptosis TAS GO:0007346 regulation of mitotic cell cycle IEA GO:0010832 negative regulation of myotube differentiation IMP GO:0016568 chromatin modification TAS GO:0016575 histone deacetylation IMP GO:0016575 histone deacetylation TAS GO:0032922 circadian regulation of gene expression IEA GO:0040014 regulation of multicellular organism growth IEA GO:0042493 response to drug IEA GO:0044255 cellular lipid metabolic process TAS GO:0045786 negative regulation of cell cycle TAS GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0046329 negative regulation of JNK cascade IMP GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0051225 spindle assembly IMP cellular_component GO:0000118 histone deacetylase complex TAS GO:0000785 chromatin IEA GO:0005634 nucleus IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm TAS GO:0005876 spindle microtubule IDA GO:0017053 transcriptional repressor complex IDA molecular_function GO:0003677 DNA binding IEA GO:0003682 chromatin binding IEA GO:0003714 transcription corepressor activity IMP GO:0004407 histone deacetylase activity IEA GO:0004407 histone deacetylase activity IMP GO:0004407 histone deacetylase activity TAS GO:0005515 protein binding IPI GO:0008134 transcription factor binding TAS GO:0016787 hydrolase activity IEA GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA GO:0033558 protein deacetylase activity IDA GO:0034739 histone deacetylase activity (H3-K16 specific) IEA GO:0042826 histone deacetylase binding IPI GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IEA GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) IEA

Protein-protein interaction details for HDAC3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MAPK11 Two-hybrid physical 15356147 ZBTB16 Reconstituted Complex physical 15467736 SF3B1 Affinity Capture-MS physical 17353931 CCND1 Affinity Capture-Western physical 15558026 CTBP1 Reconstituted Complex physical 11022042 MAPK11 Far Western physical 15356147 MAPK11 Reconstituted Complex physical 15356147 RUNX2 Affinity Capture-Western physical 15292260 RUNX2 Reconstituted Complex physical 15292260 ANKRD11 Reconstituted Complex physical 15184363 ANKRD11 Affinity Capture-Western physical 15184363 ANKRD11 Affinity Capture-Western physical 15184363 GATA1 Affinity Capture-Western physical 14668799 GATA1 Affinity Capture-Western physical 14668799 GATA1 Reconstituted Complex physical 14668799 NCOR1 Affinity Capture-MS physical 14527417 NCOR1 Affinity Capture-Western physical 14527417 ZBTB33 Affinity Capture-Western physical 14527417 NCOR2 Affinity Capture-Western physical 14527417 ZBTB33 Affinity Capture-MS physical 14527417 NR2C1 Reconstituted Complex physical 14521922 NR2C1 Affinity Capture-Western physical 14521922 RARA Reconstituted Complex physical 12943985 RXRA Reconstituted Complex physical 12943985 NR2C1 Reconstituted Complex physical 12943985 NR2C2 Reconstituted Complex physical 12943985 AR Reconstituted Complex physical 12943985 PPARD Reconstituted Complex physical 12943985 PPARG Reconstituted Complex physical 12943985 NR2C1 Two-hybrid physical 12943985 JUN Affinity Capture-Western physical 12853483 NCOR1 Affinity Capture-Western physical 12628926 NCOR1 Affinity Capture-Western physical 12628926 NCOR2 Affinity Capture-Western physical 12628926 HDAC9 Reconstituted Complex physical 12590135 GATA2 Affinity Capture-Western physical 11567998 GATA2 Affinity Capture-Western physical 11567998 NCOR2 Affinity Capture-MS physical 10809664 NCOR2 Affinity Capture-Western physical 10809664 NCOR2 Co-purification physical 10809664 YY1 Reconstituted Complex physical 9346952 PPARG Affinity Capture-Western physical 12479814 PPARG Reconstituted Complex physical 12479814 RB1 Affinity Capture-Western physical 12479814 PPARG Affinity Capture-Western physical 12479814 GTF2I Affinity Capture-Western physical 12393887 GTF2I Reconstituted Complex physical 12393887 NR2C1 Affinity Capture-Western physical 11463856 NR2C1 Two-hybrid physical 11463856 NR2C1 Reconstituted Complex physical 11463856 RBBP4 Reconstituted Complex physical 11470869 RBBP4 Reconstituted Complex physical 11470869 TAB2 Reconstituted Complex physical 12150997 TAB2 Affinity Capture-Western physical 12150997 HDAC9 Affinity Capture-Western physical 10655483 GTF2I Affinity Capture-Western physical 12239342 GTF2IRD1 Affinity Capture-Western physical 12239342 HDAC4 Affinity Capture-Western physical 10220385 HDAC5 Affinity Capture-Western physical 10220385 RELA Affinity Capture-Western physical 11533489 RELA Affinity Capture-Western physical 11533489 HDAC10 Affinity Capture-Western physical 11861901 HDAC4 Affinity Capture-Western physical 11804585 HDAC5 Affinity Capture-Western physical 11804585 HDAC4 Reconstituted Complex physical 11804585 NCOR1 Affinity Capture-Western physical 11804585 NCOR2 Affinity Capture-Western physical 11804585 NCOR2 Affinity Capture-Western physical 11804585 NCOR1 Affinity Capture-Western physical 11804585 HDAC4 Co-fractionation physical 11804585 HSPA4 Affinity Capture-Western physical 11777905 HDAC7 Reconstituted Complex physical 11466315 HDAC7 Affinity Capture-Western physical 11466315 NCOR1 Reconstituted Complex physical 11466315 HDAC4 Reconstituted Complex physical 11466315 XPO1 Affinity Capture-Western physical 11779848 HDAC3 Affinity Capture-Western physical 11779848 HDAC3 Reconstituted Complex physical 11779848 TBL1X Affinity Capture-MS physical 11931768 TBL1XR1 Affinity Capture-MS physical 11931768 GPS2 Affinity Capture-MS physical 11931768 NCOR1 Affinity Capture-Western physical 11931768 NCOR1 Affinity Capture-Western physical 11931768 TBL1X Affinity Capture-Western physical 11931768 GPS2 Affinity Capture-Western physical 11931768 HDAC5 Affinity Capture-Western physical 11931768 NCOR1 Co-fractionation physical 11931768 GPS2 Affinity Capture-Western physical 11931768 TBL1X Affinity Capture-Western physical 11931768 CCND1 Affinity Capture-Western physical 12048199 NCOR2 Affinity Capture-Western physical 12502735 TCP1 Affinity Capture-Western physical 12502735 HSPA8 Reconstituted Complex physical 12502735 TCP1 Reconstituted Complex physical 12502735 CCT5 Reconstituted Complex physical 12502735 NCOR2 Reconstituted Complex physical 12502735 NCOR2 Reconstituted Complex physical 12502735 NCOR2 Affinity Capture-Western physical 12502735 YY1 Affinity Capture-Western physical 11486036 PML Affinity Capture-Western physical 11259576 PML Reconstituted Complex physical 11259576 RB1 Affinity Capture-Western physical 10490602 RBL1 Affinity Capture-Western physical 10490602 RB1 Affinity Capture-Western physical 10490602 PPARD Affinity Capture-Western physical 11867749 BCOR Affinity Capture-Western physical 10898795 DAXX Far Western physical 10669754 CBFA2T3 Affinity Capture-Western physical 12242670 VHL Reconstituted Complex physical 11641274 HIF1AN Reconstituted Complex physical 11641274 HIF1A Reconstituted Complex physical 11641274 NCOR2 Co-fractionation physical 10944117 NCOR2 Co-purification physical 10944117 NCOR2 Affinity Capture-Western physical 10944117 NCOR1 Affinity Capture-Western physical 10944117 NCOR1 Reconstituted Complex physical 10944117 NCOR1 Reconstituted Complex physical 10944117 NCOR1 Two-hybrid physical 10944117 NCOR1 Co-purification physical 11013263 NCOR2 Co-purification physical 11013263 NCOR2 Affinity Capture-Western physical 10809664 TBL1X Affinity Capture-Western physical 10809664 NCOR2 Reconstituted Complex physical 10809664 TBL1X Reconstituted Complex physical 10809664 IKZF1 Affinity Capture-Western physical 12015313 RUNX1T1 Affinity Capture-Western physical 11533236 CBFA2T3 Affinity Capture-Western physical 11533236 HDAC4 Affinity Capture-Western physical 10869435 HDAC5 Affinity Capture-Western physical 10869435 SUV39H1 Affinity Capture-Western physical 11788710 SUV39H1 Reconstituted Complex physical 11788710 HR Affinity Capture-Western physical 11641275 UBC Affinity Capture-MS physical 18655026 UBC Affinity Capture-Western physical 18655026 SREBF2 Reconstituted Complex physical 18403372 THRA Affinity Capture-Western physical 11889044 SKI Affinity Capture-Western physical 16987993 GTF2I Affinity Capture-Western physical 17970752 SKI Affinity Capture-Western physical 19341714 AKT1 Affinity Capture-Western physical 20026773 YY1 Affinity Capture-Western physical 19279113 EP300 Affinity Capture-Western physical 19279113 YY1 Reconstituted Complex physical 19279113 ZBTB7A Affinity Capture-Western physical 19244234 NR2C1 Two-hybrid physical 19204783 NR2C1 Affinity Capture-Western physical 19204783 NR2C1 Reconstituted Complex physical 19204783 BRMS1 Reconstituted Complex physical 17227585 SMARCA4 Affinity Capture-Western physical 19081374 DACH1 Affinity Capture-Western physical 17182846 NUDT21 Affinity Capture-Western physical 17172643 PAPOLA Affinity Capture-Western physical 17172643 EP300 Reconstituted Complex physical 17158926 KAT2B Reconstituted Complex physical 17158926 MEF2D Biochemical Activity physical 17158926 SRF Affinity Capture-Western physical 17158926 MEF2D Affinity Capture-Western physical 17158926 MEF2D Affinity Capture-Western physical 17158926 KAT2B Affinity Capture-Western physical 17158926 EP300 Affinity Capture-Western physical 17158926 XPO1 Affinity Capture-Western physical 17141982 ZFP36 Affinity Capture-Western physical 19738286 SKI Affinity Capture-Western physical 19032343 ATXN3 Affinity Capture-Western physical 17079677 ATXN3 Reconstituted Complex physical 17079677 ATXN3 Reconstituted Complex physical 17079677 ATXN3 Affinity Capture-Western physical 17079677 GATA3 Affinity Capture-Western physical 17075044 GATA3 Affinity Capture-Western physical 17075044 ZNF148 Affinity Capture-Western physical 19583777 ZNF148 Affinity Capture-Western physical 19583777 ZNF148 Co-localization physical 19583777 NRIP1 Two-hybrid physical 17053781 NRIP1 Affinity Capture-Western physical 17053781 SMAD7 Affinity Capture-Western physical 15831498 EWSR1 Two-hybrid physical 20211142 PROX1 Affinity Capture-Western physical 18948102 YY1 Affinity Capture-Western physical 18940814 GTF2I Affinity Capture-Western physical 16943425 GMNN Affinity Capture-Western physical 16924111 REPIN1 Affinity Capture-Western physical 16924111 NCOR2 Affinity Capture-Western physical 16924111 NCOR1 Affinity Capture-Western physical 16917504 CNTN2 Affinity Capture-Western physical 16865259 MAGEA2 Affinity Capture-Western physical 16847267 MAGEA2 Affinity Capture-Western physical 16847267 SAP30L Affinity Capture-Western physical 16820529 SAP30 Affinity Capture-Western physical 16820529 NFATC1 Co-localization physical 19463978 PRAM1 Affinity Capture-Western physical 16730330 CNOT2 Affinity Capture-Western physical 16712523 RUNX1 Affinity Capture-Western physical 16652147 RBM15 Affinity Capture-Western physical 18667423 RBM15 Affinity Capture-Western physical 18667423 INSM1 Affinity Capture-Western physical 16569215 CEBPD Affinity Capture-Western physical 18619497 SRC Affinity Capture-Western physical 16532030 SRC Affinity Capture-Western physical 16532030 SRC Biochemical Activity physical 16532030 GCM1 Affinity Capture-Western physical 16528103 GCM1 Affinity Capture-Western physical 16528103 CREBBP Affinity Capture-Western physical 16528103 CREBBP Affinity Capture-Western physical 16528103 GCM1 Reconstituted Complex physical 16528103 CREBBP Reconstituted Complex physical 16528103 GCM1 Reconstituted Complex physical 16528103 CREBBP Reconstituted Complex physical 16528103 NCOR2 Affinity Capture-Western physical 16481466 PRAM1 Affinity Capture-Western physical 16432238 MBD1 Affinity Capture-Western physical 16432238 NFKBIA Affinity Capture-Western physical 16371367 NFKB1 Affinity Capture-Western physical 12972430 HDAC4 Affinity Capture-Western physical 18558095 YY1 Affinity Capture-Western physical 18558095 SP1 Affinity Capture-Western physical 16298343 SYK Affinity Capture-Western physical 16288017 SYK Reconstituted Complex physical 16288017 EP300 Affinity Capture-Western physical 18542060 YY1 Affinity Capture-Western physical 18542060 YY1 Reconstituted Complex physical 18542060 EP300 Reconstituted Complex physical 18542060 CBFA2T2 Affinity Capture-Western physical 16227606 PARP1 Affinity Capture-Western physical 16204234 PARP1 Reconstituted Complex physical 16204234 SAFB Affinity Capture-Western physical 16195251 SAFB2 Affinity Capture-Western physical 16195251 NCOR1 Two-hybrid physical 16195251 PPA1 Affinity Capture-Western physical 16186112 LCOR Reconstituted Complex physical 12535528 LCOR Affinity Capture-Western physical 12535528 MYC Affinity Capture-Western physical 18483244 NCOR2 Reconstituted Complex physical 12205093 HNF4A Reconstituted Complex physical 12205093 TMPO Two-hybrid physical 16129885 TMPO Reconstituted Complex physical 16129885 TMPO Affinity Capture-Western physical 16129885 GTF2IRD1 Affinity Capture-Western physical 16055724 KDM4A Affinity Capture-Western physical 15927959 KLF6 Affinity Capture-Western physical 15917248 KLF6 Affinity Capture-Western physical 15917248 NCOR2 Affinity Capture-Western physical 15837933 NR0B2 Reconstituted Complex physical 15835920 HIST1H4A Biochemical Activity physical 15832170 SMAD7 Affinity Capture-Western physical 15831516 CSNK2A1 Biochemical Activity physical 15805470 PPP4C Reconstituted Complex physical 15805470 PPP4C Affinity Capture-Western physical 15805470 CCND1 Affinity Capture-Western physical 15713663 CCND1 Co-localization physical 15713663 STAT3 Affinity Capture-Western physical 15653507 STAT3 Affinity Capture-Western physical 15653507 ANKRD12 Reconstituted Complex physical 18377363 THAP7 Affinity Capture-Western physical 15561719 THAP7 Reconstituted Complex physical 15561719 RUNX2 Affinity Capture-Western physical 18321663 ETV6 Affinity Capture-Western physical 11439334 ETV6 Affinity Capture-Western physical 11439334 TBX3 Affinity Capture-Western physical 18245468 MAFK Affinity Capture-Western physical 18241676 NFKB1 Co-localization physical 15494311 TBL1X Affinity Capture-Western physical 18202150 TBL1XR1 Affinity Capture-Western physical 18202150 RUNX1T1 Affinity Capture-Western physical 15333839 SRY Reconstituted Complex physical 15297880 PBX1 Affinity Capture-Western physical 11046157 RB1 Affinity Capture-Western physical 10958676 NCOR1 Affinity Capture-MS physical 10860984 NCOR2 Affinity Capture-MS physical 10860984 NCOR1 Reconstituted Complex physical 10860984 NCOR1 Two-hybrid physical 10860984 RELA Affinity Capture-Western physical 15192014 RELA Affinity Capture-Western physical 15192014 PHB2 Reconstituted Complex physical 15140878 IL16 Reconstituted Complex physical 18097041 IL16 Affinity Capture-Western physical 18097041 TCF19 Affinity Capture-Western physical 15051733 YY1 Affinity Capture-Western physical 17925399 ESR1 Co-localization physical 14722073 NCOR1 Co-localization physical 14722073 CEBPD Reconstituted Complex physical 17910034 NR2E1 Affinity Capture-Western physical 17873065 NR2E1 Affinity Capture-Western physical 17873065 SRC Affinity Capture-Western physical 17699109 SKI Affinity Capture-Western physical 17621263 SPI1 Affinity Capture-Western physical 17621263 SKI Affinity Capture-Western physical 17621263 EMD Affinity Capture-MS physical 17620012 EMD Affinity Capture-Western physical 17620012 CCND1 Affinity Capture-Western physical 20484017 OVOL1 Affinity Capture-Western physical 17311813 OVOL1 Affinity Capture-Western physical 17311813 CREB3 Two-hybrid physical 20473547 CREB3 Affinity Capture-Western physical 20473547 CREB3 Affinity Capture-Western physical 20473547 CREB3 Reconstituted Complex physical 20473547 CREB3 Reconstituted Complex physical 20473547 HIF1A Affinity Capture-Western physical 17273746 HIF1A Reconstituted Complex physical 17273746 BCL11B Affinity Capture-Western physical 17245431 THRA Affinity Capture-MS physical 17242407 THRB Affinity Capture-MS physical 17242407 THRA Reconstituted Complex physical 17242407 THRB Reconstituted Complex physical 17242407 PRKDC Biochemical Activity physical 17242407 L3MBTL2 Reconstituted Complex physical 20385135 L3MBTL2 Reconstituted Complex physical 20385135 L3MBTL2 Affinity Capture-Western physical 20385135 L3MBTL2 Affinity Capture-Western physical 20385135 BCL3 Affinity Capture-Western physical 20547759 NR1D1 Affinity Capture-Western physical 20534529 NOS3 Affinity Capture-Western physical 20705923 SIAH2 Affinity Capture-Western physical 20691163 DHX30 Affinity Capture-MS physical 17255935 DHX30 Affinity Capture-Western physical 17255935 NR2E3 Affinity Capture-Western physical 17255935 HDAC5 Affinity Capture-Western physical 21081666 HDAC5 Affinity Capture-MS physical 21081666 PARP14 Affinity Capture-Western physical 21081493 RUNX1 Affinity Capture-Western physical 21059642 RUNX1 Affinity Capture-Western physical 21059642 RUNX1 Reconstituted Complex physical 21059642 DBC1 Affinity Capture-Western physical 21030595 DBC1 Reconstituted Complex physical 21030595 BCL3 Affinity Capture-Western physical 15469820 SAFB Affinity Capture-Western physical 21527249