Entrez gene ID | | 9656 |
Official gene symbol | | MDC1 |
Full name | | mediator of DNA-damage checkpoint 1 |
Aliases | | ,DKFZp781A0122,KIAA0170,MGC166888,NFBD1, |
Gene summary | | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6p21.3 |
Gene position | | 30685458 - 30667584 Map Viewer |
Gene orientation | | minus |
Gene size | | 17875 bp |
Gene sequence |
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OMIM ID | | 607593 |