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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MDC1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000724 double-strand break repair via homologous recombination TAS GO:0006281 DNA repair TAS GO:0006302 double-strand break repair TAS GO:0007049 cell cycle IEA GO:0031573 intra-S DNA damage checkpoint TAS cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IDA GO:0005925 focal adhesion IDA molecular_function GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IPI GO:0070975 FHA domain binding IPI

Protein-protein interaction details for MDC1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID H2AFX Reconstituted Complex physical 12607005 H2AFX Affinity Capture-Western physical 12607005 CENPC1 Protein-peptide physical 14578343 GATA4 Protein-peptide physical 14578343 HDAC10 Protein-peptide physical 14578343 HDAC8 Protein-peptide physical 14578343 MDM2 Protein-peptide physical 14578343 POLR2A Protein-peptide physical 14578343 WRN Protein-peptide physical 14578343 MRE11A Affinity Capture-MS physical 14519663 MRE11A Affinity Capture-Western physical 14519663 NBN Affinity Capture-Western physical 14519663 RAD50 Affinity Capture-Western physical 14519663 TP53 Affinity Capture-Western physical 14519663 H2AFX Affinity Capture-Western physical 14519663 ATM Affinity Capture-Western physical 14519663 CHEK2 Affinity Capture-Western physical 12607004 CHEK2 Reconstituted Complex physical 12607004 BRCA1 Affinity Capture-Western physical 17525332 UBC Affinity Capture-Western physical 18757370 USP28 Affinity Capture-Western physical 16901786 BANF1 Affinity Capture-MS physical 19759913 TP53BP1 Affinity Capture-Western physical 18986980 TP53BP1 Affinity Capture-Western physical 18986980 TP53BP1 Reconstituted Complex physical 18986980 MCPH1 Co-localization physical 16872911 SUMO2 Affinity Capture-MS physical 19394292 RAD51 Affinity Capture-Western physical 16186822 RAD51 Affinity Capture-Western physical 16186822 RAD51 Reconstituted Complex physical 16186822 MRE11A Affinity Capture-MS physical 12607003 MRE11A Affinity Capture-Western physical 12607003 RAD50 Affinity Capture-Western physical 12607003 RAD50 Affinity Capture-Western physical 12607003 MRE11A Affinity Capture-Western physical 12607003 NBN Affinity Capture-Western physical 12607003 NBN Affinity Capture-Western physical 12607003 MRE11A Reconstituted Complex physical 12607003 H2AFX Affinity Capture-Western physical 15201865 NBN Affinity Capture-Western physical 15201865 RNF8 Reconstituted Complex physical 18001825 RNF8 Affinity Capture-Western physical 18001824 RNF8 Affinity Capture-Western physical 18001824 TP53BP1 Co-localization physical 17925396 ANAPC1 Affinity Capture-MS physical 17827148 ANAPC5 Affinity Capture-MS physical 17827148 CDC16 Affinity Capture-MS physical 17827148 CDC27 Reconstituted Complex physical 17827148 CDC27 Affinity Capture-Western physical 17827148 CDC16 Affinity Capture-Western physical 17827148 NBN Affinity Capture-Western physical 20460517 BIRC5 Affinity Capture-Western physical 20394854 BIRC5 Affinity Capture-Western physical 20394854 ATM Biochemical Activity physical 18006705 RNF8 Reconstituted Complex physical 18006705 RNF8 Affinity Capture-Western physical 18006705 UIMC1 Co-localization physical 21857162 UBC Affinity Capture-Western physical 21622030 BRCA1 Affinity Capture-Western physical 21622030 UIMC1 Affinity Capture-Western physical 21622030 UIMC1 Affinity Capture-Western physical 21622030 BRCA1 Affinity Capture-Western physical 21622030 UIMC1 Co-fractionation physical 21622030 UIMC1 Reconstituted Complex physical 21622030 UIMC1 Reconstituted Complex physical 21622030 H2AFX Reconstituted Complex physical 21622030 H2AFX Affinity Capture-Western physical 21622030 HERC2 Affinity Capture-Western physical 20023648 EP300 Affinity Capture-MS physical 16051665 UBC Affinity Capture-MS physical 22108332