Entrez gene ID | | 9759 |
Official gene symbol | | HDAC4 |
Full name | | histone deacetylase 4 |
Aliases | | ,HA6116,HD4,HDAC-A,HDACA,KIAA0288, |
Gene summary | | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q37.3 |
Gene position | | 240322643 - 239969864 Map Viewer |
Gene orientation | | minus |
Gene size | | 352780 bp |
Gene sequence |
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OMIM ID | | 605314 |
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