Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HDAC4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9759
Official gene symbolHDAC4
Full namehistone deacetylase 4
Aliases,HA6116,HD4,HDAC-A,HDACA,KIAA0288,
Gene summaryHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q37.3
Gene position240322643 - 239969864  Map Viewer
Gene orientationminus
Gene size352780 bp
Gene sequence
OMIM ID605314