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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HDAC4 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0001501 skeletal system development IEA GO:0002076 osteoblast development IEA GO:0006338 chromatin remodeling IDA GO:0006954 inflammatory response TAS GO:0007399 nervous system development TAS GO:0008284 positive regulation of cell proliferation IMP GO:0008285 negative regulation of cell proliferation IEA GO:0010832 negative regulation of myotube differentiation IMP GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IEA GO:0014894 response to denervation involved in regulation of muscle adaptation IEA GO:0014894 response to denervation involved in regulation of muscle adaptation ISS GO:0014898 cardiac muscle hypertrophy in response to stress TAS GO:0016568 chromatin modification IEA GO:0016575 histone deacetylation IDA GO:0016575 histone deacetylation IMP GO:0030183 B cell differentiation TAS GO:0033235 positive regulation of protein sumoylation IDA GO:0034983 peptidyl-lysine deacetylation IDA GO:0042113 B cell activation TAS GO:0043393 regulation of protein binding IMP GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IMP GO:0045668 negative regulation of osteoblast differentiation IEA GO:0045820 negative regulation of glycolysis IEA GO:0045820 negative regulation of glycolysis ISS GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045893 positive regulation of transcription, DNA-dependent ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IMP GO:0070555 response to interleukin-1 IMP GO:0070932 histone H3 deacetylation IDA GO:0070933 histone H4 deacetylation IDA cellular_component GO:0000118 histone deacetylase complex IDA GO:0000118 histone deacetylase complex IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol IEA GO:0017053 transcriptional repressor complex IDA GO:0031594 neuromuscular junction IEA GO:0042641 actomyosin IEA molecular_function GO:0003677 DNA binding IEA GO:0003714 transcription corepressor activity IEA GO:0004407 histone deacetylase activity IDA GO:0004407 histone deacetylase activity IEA GO:0005515 protein binding IPI GO:0008134 transcription factor binding IEA GO:0008134 transcription factor binding IPI GO:0008270 zinc ion binding IDA GO:0016787 hydrolase activity IEA GO:0030955 potassium ion binding IDA GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA GO:0033558 protein deacetylase activity IDA GO:0033558 protein deacetylase activity IEA GO:0033613 activating transcription factor binding IPI GO:0034739 histone deacetylase activity (H3-K16 specific) IEA GO:0042826 histone deacetylase binding IPI GO:0043565 sequence-specific DNA binding IDA GO:0044212 transcription regulatory region DNA binding IDA GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IEA GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) IEA GO:0070491 repressing transcription factor binding IPI

Protein-protein interaction details for HDAC4 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ZBTB16 Reconstituted Complex physical 15467736 ZBTB16 Affinity Capture-Western physical 15467736 SFN Affinity Capture-MS physical 15778465 CTBP1 Reconstituted Complex physical 11022042 GATA1 Affinity Capture-Western physical 14668799 GATA1 Affinity Capture-Western physical 14668799 GATA1 Reconstituted Complex physical 14668799 RARA Reconstituted Complex physical 12943985 RXRA Reconstituted Complex physical 12943985 NR2C1 Reconstituted Complex physical 12943985 NR2C2 Reconstituted Complex physical 12943985 AR Reconstituted Complex physical 12943985 PPARD Reconstituted Complex physical 12943985 PPARG Reconstituted Complex physical 12943985 IKZF2 Reconstituted Complex physical 12943985 ZNF354A Reconstituted Complex physical 12943985 HDAC9 Reconstituted Complex physical 12590135 MEF2A Affinity Capture-Western physical 10487761 MEF2A Reconstituted Complex physical 10487761 MEF2C Affinity Capture-Western physical 10523670 MEF2D Affinity Capture-Western physical 10523670 MEF2C Reconstituted Complex physical 10523670 HDAC4 Reconstituted Complex physical 11486037 MEF2C Reconstituted Complex physical 11486037 NR2C1 Affinity Capture-Western physical 11463856 NR2C1 Reconstituted Complex physical 11463856 RBBP4 Affinity Capture-Western physical 10220385 HDAC3 Affinity Capture-Western physical 10220385 HDAC3 Affinity Capture-Western physical 11804585 HDAC3 Reconstituted Complex physical 11804585 NCOR1 Reconstituted Complex physical 11804585 NCOR2 Reconstituted Complex physical 11804585 NCOR1 Affinity Capture-Western physical 11804585 NCOR1 Reconstituted Complex physical 11804585 HDAC3 Co-fractionation physical 11804585 HDAC3 Reconstituted Complex physical 11466315 YWHAE Reconstituted Complex physical 11504882 YWHAG Reconstituted Complex physical 11504882 YWHAZ Reconstituted Complex physical 11504882 BCL6 Affinity Capture-Western physical 11929873 BCL6 Reconstituted Complex physical 11929873 ZBTB16 Reconstituted Complex physical 11929873 BCOR Affinity Capture-Western physical 10898795 IKZF1 Affinity Capture-Western physical 12015313 IKZF3 Affinity Capture-Western physical 12015313 IKZF4 Affinity Capture-Western physical 12015313 NCOR1 Affinity Capture-Western physical 10640275 NCOR1 Affinity Capture-Western physical 10640275 NCOR1 Reconstituted Complex physical 10640275 NCOR2 Reconstituted Complex physical 10640275 NCOR2 Affinity Capture-Western physical 10640275 MEF2A Reconstituted Complex physical 10748098 YWHAB Affinity Capture-Western physical 10869435 YWHAE Affinity Capture-Western physical 10869435 HDAC3 Affinity Capture-Western physical 10869435 YWHAB Affinity Capture-Western physical 10869435 MECOM Affinity Capture-Western physical 11568182 CBX5 Reconstituted Complex physical 12242305 CBX5 Affinity Capture-Western physical 12242305 SUV39H1 Affinity Capture-Western physical 12242305 UBE2I Biochemical Activity physical 18691969 MAPK3 Affinity Capture-Western physical 11114188 MAPK1 Affinity Capture-Western physical 11114188 MAPK3 Biochemical Activity physical 11114188 MAPK1 Biochemical Activity physical 11114188 FOXP3 Co-localization physical 19276356 SUMO2 Affinity Capture-Western physical 16955485 DNAJB6 Affinity Capture-Western physical 20159555 DNAJB8 Affinity Capture-Western physical 20159555 DNAJB8 Affinity Capture-Western physical 20159555 DNAJB6 Affinity Capture-Western physical 20159555 ATF2 Affinity Capture-Western physical 20116378 ATF2 Affinity Capture-Western physical 20116378 MORC2 Co-localization physical 20110259 RUNX2 Affinity Capture-Western physical 20097749 RUNX2 Affinity Capture-Western physical 20097749 SENP1 Co-localization physical 20079608 RUNX2 Affinity Capture-Western physical 16613856 CDK5 Affinity Capture-Western physical 16356933 SUMO1 Affinity Capture-Western physical 16332688 PARK2 Affinity Capture-Western physical 16332688 NR1H2 Biochemical Activity physical 17218271 NR1H2 Reconstituted Complex physical 17218271 SIN3A Affinity Capture-Western physical 17210713 HIF1A Affinity Capture-Western physical 19071119 HIF1A Reconstituted Complex physical 19071119 CAMK2D Biochemical Activity physical 17179159 CAMK2D Affinity Capture-Western physical 17179159 YWHAE Two-hybrid physical 20936779 MEF2D Affinity Capture-Western physical 17158926 ESR1 Reconstituted Complex physical 19893013 YY1 Affinity Capture-Western physical 19013255 YY1 Affinity Capture-Western physical 19013255 LZTR1 Two-hybrid physical 20211142 SS18L1 Two-hybrid physical 20211142 SP1 Affinity Capture-Western physical 18850004 SP1 Affinity Capture-Western physical 18850004 REST Affinity Capture-Western physical 17011572 SIN3A Affinity Capture-Western physical 17011572 MARK3 Affinity Capture-Western physical 16980613 HIF1A Affinity Capture-Western physical 16951198 GATA3 Affinity Capture-Western physical 16922677 YY1 Affinity Capture-Western physical 16922677 CAMK2D Affinity Capture-Western physical 16767219 CAMK2D Reconstituted Complex physical 16767219 CAMK2D Biochemical Activity physical 16767219 CAMK1 Affinity Capture-Western physical 16767219 SP1 Affinity Capture-Western physical 18632985 GCM1 Affinity Capture-Western physical 16528103 GCM1 Affinity Capture-Western physical 16528103 MEF2A Reconstituted Complex physical 19389706 MEF2D Affinity Capture-Western physical 16356933 NUP214 Affinity Capture-Western physical 16356933 YY1 Affinity Capture-Western physical 18558095 HDAC3 Affinity Capture-Western physical 18558095 YY1 Affinity Capture-Western physical 18558095 DNAJB5 Affinity Capture-Western physical 18555775 SYK Reconstituted Complex physical 16288017 ESCO2 Affinity Capture-Western physical 18501190 GNB1 Affinity Capture-Western physical 16221676 GNB1 Reconstituted Complex physical 16221676 CTNNB1 Affinity Capture-Western physical 16204248 MEF2C Reconstituted Complex physical 12709441 TP53BP1 Affinity Capture-Western physical 12668657 TP53BP1 Affinity Capture-Western physical 12668657 SRF Affinity Capture-Western physical 12663674 SRF Reconstituted Complex physical 12663674 SRF Reconstituted Complex physical 12663674 UBE2I Two-hybrid physical 16166628 UBE2I Affinity Capture-Western physical 16166628 SUMO1 Affinity Capture-Western physical 16166628 MEF2D Affinity Capture-Western physical 16166628 SIRT1 Affinity Capture-Western physical 16166628 LCOR Reconstituted Complex physical 12535528 NCOR2 Reconstituted Complex physical 12205093 HNF4A Reconstituted Complex physical 12205093 CDKN1A Reconstituted Complex physical 16082198 RANBP2 Biochemical Activity physical 12032081 ESR1 Reconstituted Complex physical 16051668 ESR1 Affinity Capture-Western physical 16051668 ESR1 Two-hybrid physical 16051668 ESR1 Affinity Capture-Western physical 16051668 SMAD3 Affinity Capture-Western physical 15990875 SMAD3 Reconstituted Complex physical 15990875 MEF2C Two-hybrid physical 15964851 YWHAQ Two-hybrid physical 15964851 ANKRA2 Two-hybrid physical 15964851 ATRX Two-hybrid physical 15964851 REV3L Two-hybrid physical 15964851 MAP1S Two-hybrid physical 15964851 ANKRA2 Reconstituted Complex physical 15964851 RFXANK Reconstituted Complex physical 15964851 RFXANK Affinity Capture-Western physical 15964851 CIITA Affinity Capture-Western physical 15964851 CIITA Affinity Capture-Western physical 15964851 RFX5 Affinity Capture-Western physical 15964851 RFXAP Affinity Capture-Western physical 15964851 MEF2C Affinity Capture-Western physical 15743821 IFRD1 Reconstituted Complex physical 15743821 PPP2CA Affinity Capture-Western physical 18339811 RUNX2 Affinity Capture-Western physical 15537544 NFKBIA Affinity Capture-Western physical 15536134 NFKBIE Reconstituted Complex physical 15536134 HDAC4 Affinity Capture-Western physical 18332106 HDAC5 Affinity Capture-Western physical 18332106 HDAC5 Affinity Capture-Western physical 18332106 MEF2C Affinity Capture-Western physical 18332106 CAMK4 Biochemical Activity physical 11470791 YWHAQ Affinity Capture-Western physical 11470791 CSRP3 Affinity Capture-Western physical 18250163 CSRP3 Reconstituted Complex physical 18250163 MEF2C Reconstituted Complex physical 11279209 HDAC7 Reconstituted Complex physical 11279209 YWHAB Affinity Capture-Western physical 10958686 YWHAB Affinity Capture-Western physical 10958686 NCOR1 Reconstituted Complex physical 10860984 NCOR1 Two-hybrid physical 10860984 DNAJB6 Affinity Capture-Western physical 18163532 PPP2R4 Reconstituted Complex physical 18045992 AHRR Affinity Capture-Western physical 17949687 CEBPD Reconstituted Complex physical 17910034 BCORL1 Affinity Capture-Western physical 17379597 NUP155 Two-hybrid physical 21464227 NUP155 Affinity Capture-Western physical 21464227 NUP155 Reconstituted Complex physical 21464227 NUP155 Reconstituted Complex physical 21464227 ACTA1 Reconstituted Complex physical 21464227 NPPB Reconstituted Complex physical 21464227 CACNA1C Reconstituted Complex physical 21464227 ATXN1 Affinity Capture-Western physical 17646162 HIC1 Affinity Capture-Western physical 17283066 AR Affinity Capture-Western physical 21242980 AR Affinity Capture-Western physical 21242980 AR Reconstituted Complex physical 21242980 AR Reconstituted Complex physical 21242980 AR Biochemical Activity physical 21242980 BCL6 Affinity Capture-MS physical 16147992 YWHAQ Affinity Capture-MS physical 15161933 YWHAQ Affinity Capture-Western physical 15161933 YWHAG Affinity Capture-MS physical 15324660 NFKB1 Affinity Capture-Western physical 12917325 SF1 Affinity Capture-Western physical 12917325