Entrez gene ID | | 9826 |
Official gene symbol | | ARHGEF11 |
Full name | | Rho guanine nucleotide exchange factor (GEF) 11 |
Aliases | | ,DKFZp667F1223,GTRAP48,KIAA0380,PDZ-RHOGEF, |
Gene summary | | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q21 |
Gene position | | 157015162 - 156904632 Map Viewer |
Gene orientation | | minus |
Gene size | | 110531 bp |
Gene sequence |
| |
OMIM ID | | 605708 |