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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ARHGEF11 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9826
Official gene symbolARHGEF11
Full nameRho guanine nucleotide exchange factor (GEF) 11
Aliases,DKFZp667F1223,GTRAP48,KIAA0380,PDZ-RHOGEF,
Gene summaryRho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q21
Gene position157015162 - 156904632  Map Viewer
Gene orientationminus
Gene size110531 bp
Gene sequence
OMIM ID605708