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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CDC42 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID998
Official gene symbolCDC42
Full namecell division cycle 42 (GTP binding protein, 25kDa)
Aliases,CDC42Hs,G25K,
Gene summaryThe protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.1
Gene position22379120 - 22419436  Map Viewer
Gene orientationplus
Gene size40317 bp
Gene sequence
OMIM ID116952