Entrez gene ID | | 998 |
Official gene symbol | | CDC42 |
Full name | | cell division cycle 42 (GTP binding protein, 25kDa) |
Aliases | | ,CDC42Hs,G25K, |
Gene summary | | The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p36.1 |
Gene position | | 22379120 - 22419436 Map Viewer |
Gene orientation | | plus |
Gene size | | 40317 bp |
Gene sequence |
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OMIM ID | | 116952 |
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