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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CDC42 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0003334 keratinocyte development IEA GO:0006184 GTP catabolic process TAS GO:0007088 regulation of mitosis IEA GO:0007097 nuclear migration IEA GO:0007163 establishment or maintenance of cell polarity TAS GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007264 small GTPase mediated signal transduction IEA GO:0007264 small GTPase mediated signal transduction TAS GO:0007399 nervous system development IEA GO:0007411 axon guidance TAS GO:0007596 blood coagulation TAS GO:0010628 positive regulation of gene expression IEA GO:0010629 negative regulation of gene expression IEA GO:0030036 actin cytoskeleton organization IDA GO:0030225 macrophage differentiation TAS GO:0031069 hair follicle morphogenesis IEA GO:0031274 positive regulation of pseudopodium assembly IDA GO:0031295 T cell costimulation TAS GO:0031333 negative regulation of protein complex assembly IPI GO:0031424 keratinization IEA GO:0031647 regulation of protein stability IEA GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA GO:0034332 adherens junction organization IEA GO:0034613 cellular protein localization IEA GO:0035088 establishment or maintenance of apical/basal cell polarity IEA GO:0035264 multicellular organism growth IEA GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS GO:0042176 regulation of protein catabolic process IEA GO:0042692 muscle cell differentiation TAS GO:0043497 regulation of protein heterodimerization activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA GO:0045740 positive regulation of DNA replication IEA GO:0045859 regulation of protein kinase activity IEA GO:0046330 positive regulation of JNK cascade IEA GO:0046847 filopodium assembly IEA GO:0048664 neuron fate determination IEA GO:0051017 actin filament bundle assembly IEA GO:0051056 regulation of small GTPase mediated signal transduction TAS GO:0051149 positive regulation of muscle cell differentiation TAS GO:0051301 cell division IEA GO:0051489 regulation of filopodium assembly IDA GO:0051647 nucleus localization IEA GO:0051988 regulation of attachment of spindle microtubules to kinetochore IMP GO:0060070 canonical Wnt receptor signaling pathway IEA GO:0060684 epithelial-mesenchymal cell signaling IEA GO:0060789 hair follicle placode formation IEA GO:0071338 positive regulation of hair follicle cell proliferation IEA GO:0071777 positive regulation of cell cycle cytokinesis IMP GO:0090136 epithelial cell-cell adhesion IEA cellular_component GO:0000139 Golgi membrane IEA GO:0005622 intracellular IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005815 microtubule organizing center IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane TAS GO:0016020 membrane IEA GO:0030141 stored secretory granule IEA GO:0030175 filopodium IDA GO:0030496 midbody IDA GO:0042995 cell projection IEA GO:0045177 apical part of cell IEA GO:0051233 spindle midzone IDA GO:0072686 mitotic spindle IDA molecular_function GO:0000166 nucleotide binding IEA GO:0003924 GTPase activity IEA GO:0003924 GTPase activity TAS GO:0005515 protein binding IPI GO:0005525 GTP binding IEA GO:0030742 GTP-dependent protein binding IEA GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA GO:0031996 thioesterase binding IPI

Protein-protein interaction details for CDC42 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID DOCK8 Two-hybrid physical 15304341 TRIP10 Two-hybrid physical 9210375 CDC42EP1 Two-hybrid physical 16189514 ARHGDIA Affinity Capture-MS physical 17353931 PAK4 Affinity Capture-MS physical 17353931 FNBP1L Affinity Capture-Western physical 15260990 CDC42BPG Reconstituted Complex physical 15194684 ARHGAP27 Biochemical Activity physical 15147912 DEF6 Reconstituted Complex physical 15023524 ARHGAP29 Two-hybrid physical 14749388 MCF2L Affinity Capture-Western physical 14701795 BNIPL Two-hybrid physical 12901880 BNIPL Affinity Capture-Western physical 12901880 ARHGAP32 Biochemical Activity physical 12857875 ARHGAP32 Biochemical Activity physical 12819203 PAK1 Reconstituted Complex physical 12650940 TBC1D3F Reconstituted Complex physical 12612085 KAT5 Two-hybrid physical 16169070 C14orf1 Two-hybrid physical 16169070 PDE6D Two-hybrid physical 16169070 UBR1 Two-hybrid physical 16169070 C1orf103 Two-hybrid physical 16169070 TP53 Two-hybrid physical 16169070 EEF1G Two-hybrid physical 16169070 UNC119 Two-hybrid physical 16169070 BNIP2 Reconstituted Complex physical 10799524 BNIP2 Biochemical Activity physical 10799524 BNIP2 Affinity Capture-Western physical 10799524 CDC42EP3 Two-hybrid physical 9535835 BAIAP2 Far Western physical 12504591 PAK2 Protein-peptide physical 10320322 MCF2L Co-crystal Structure physical 11889037 MCF2L Reconstituted Complex physical 11889037 VAV1 Affinity Capture-Western physical 11287617 BNIP2 Two-hybrid physical 10954711 MAP3K10 Two-hybrid physical 9427749 ARHGAP1 Two-hybrid physical 9427749 MAP3K11 Two-hybrid physical 9427749 RAC1 Two-hybrid physical 9427749 MAP3K10 Reconstituted Complex physical 9427749 CDC42SE1 Two-hybrid physical 10816584 CDC42SE2 Two-hybrid physical 10816584 CDC42 Co-crystal Structure physical 10211824 CSPG4 Affinity Capture-Western physical 10587647 IQGAP2 Reconstituted Complex physical 8756646 IQGAP2 Affinity Capture-Western physical 8756646 MAP3K11 Affinity Capture-Western physical 10799501 PARD6B Two-hybrid physical 11162552 GOPC Reconstituted Complex physical 11162552 NCF2 Reconstituted Complex physical 9642115 MAP3K4 Reconstituted Complex physical 9079650 GDI1 Reconstituted Complex physical 11583574 GDI1 Affinity Capture-Western physical 11583574 TNK2 Affinity Capture-Western physical 11394904 BAIAP2 Affinity Capture-Western physical 11696321 BAIAP2 Reconstituted Complex physical 11696321 PAK4 Affinity Capture-Western physical 11756552 PAK7 Affinity Capture-Western physical 11756552 ERRFI1 Affinity Capture-Western physical 10749885 ERRFI1 Reconstituted Complex physical 10749885 PAK6 Reconstituted Complex physical 11773441 ARHGAP26 Biochemical Activity physical 11432776 ARHGAP10 Biochemical Activity physical 11432776 ARHGAP32 Biochemical Activity physical 12446789 ARHGAP17 Biochemical Activity physical 11431473 RICH2 Biochemical Activity physical 11431473 IQGAP1 Reconstituted Complex physical 8798539 IQGAP1 Affinity Capture-Western physical 8798539 PARD6A Two-hybrid physical 10934474 PARD6B Reconstituted Complex physical 10934474 PARD6B Two-hybrid physical 10934474 PARD6B Affinity Capture-Western physical 10934474 PARD6A Reconstituted Complex physical 10873802 PARD6A Affinity Capture-Western physical 10873802 OPHN1 Biochemical Activity physical 9582072 CLIP1 Affinity Capture-Western physical 12110184 IQGAP1 Affinity Capture-Western physical 12110184 WAS Reconstituted Complex physical 10713100 TRIP10 Reconstituted Complex physical 10713100 WAS Reconstituted Complex physical 10724160 TRIP10 Reconstituted Complex physical 9210375 WASL Reconstituted Complex physical 10781580 WAS Reconstituted Complex physical 8643625 ARHGAP1 Reconstituted Complex physical 9407060 MCF2 Reconstituted Complex physical 10854437 BAIAP2 Reconstituted Complex physical 11130076 ARHGDIA Co-purification physical 9490022 WAS Reconstituted Complex physical 8625410 DOCK9 Reconstituted Complex physical 12172552 CDC42EP5 Reconstituted Complex physical 11035016 CDC42EP2 Reconstituted Complex physical 11035016 PLEKHG2 Reconstituted Complex physical 11839748 ARHGDIG Reconstituted Complex physical 9113980 PAK4 Reconstituted Complex physical 9822598 PAK2 Reconstituted Complex physical 9822598 CDC42EP3 Reconstituted Complex physical 10490598 CDC42EP2 Reconstituted Complex physical 10490598 CDC42EP2 Two-hybrid physical 10490598 CDC42EP3 Two-hybrid physical 10490598 CDC42EP5 Two-hybrid physical 10490598 CDC42EP5 Reconstituted Complex physical 10490598 ARHGAP1 Reconstituted Complex physical 10551883 BNIP2 Reconstituted Complex physical 10551883 PARD6A Two-hybrid physical 11260256 PARD6B Two-hybrid physical 11260256 PARD6B Reconstituted Complex physical 11260256 PARD6A Reconstituted Complex physical 11260256 PARD6G Reconstituted Complex physical 11260256 FGD1 Reconstituted Complex physical 8969170 GEFT Reconstituted Complex physical 12547822 WASL Reconstituted Complex physical 9422512 PAK7 Reconstituted Complex physical 12032833 PAK7 Affinity Capture-Western physical 12032833 PLD1 Reconstituted Complex physical 10747870 PLD1 Affinity Capture-Western physical 10747870 IQGAP1 Reconstituted Complex physical 8670801 IQGAP1 Affinity Capture-Western physical 8670801 ITSN1 Affinity Capture-Western physical 11584276 ITSN1 Reconstituted Complex physical 11584276 IQGAP1 Reconstituted Complex physical 9182573 ITSN1 Co-crystal Structure physical 12006984 ARHGAP1 Reconstituted Complex physical 9535855 CNTNAP1 Reconstituted Complex physical 9535855 BCR Reconstituted Complex physical 9535855 PAK1 Reconstituted Complex physical 9535855 PAK2 Reconstituted Complex physical 9535855 IQGAP1 Reconstituted Complex physical 9535855 ARHGDIA Two-hybrid physical 20936779 ARRB1 Two-hybrid physical 20936779 ARRB2 Two-hybrid physical 20936779 CSN2 Two-hybrid physical 20936779 DIAPH2 Two-hybrid physical 20936779 COX1 Two-hybrid physical 20936779 MYO6 Two-hybrid physical 20936779 MYO9A Two-hybrid physical 20936779 PAK1 Two-hybrid physical 20936779 PAK2 Two-hybrid physical 20936779 PAK3 Two-hybrid physical 20936779 RAP1GDS1 Two-hybrid physical 20936779 RPL22 Two-hybrid physical 20936779 S100A9 Two-hybrid physical 20936779 ST13 Two-hybrid physical 20936779 UBC Two-hybrid physical 20936779 VRK2 Two-hybrid physical 20936779 WAS Two-hybrid physical 20936779 ZNF175 Two-hybrid physical 20936779 CDC42BPA Two-hybrid physical 20936779 MCM3AP Two-hybrid physical 20936779 HERC2 Two-hybrid physical 20936779 WASL Two-hybrid physical 20936779 RPL23 Two-hybrid physical 20936779 CDC42BPB Two-hybrid physical 20936779 ARHGAP32 Two-hybrid physical 20936779 ARHGEF11 Two-hybrid physical 20936779 TNK2 Two-hybrid physical 20936779 PAK4 Two-hybrid physical 20936779 CDC42EP2 Two-hybrid physical 20936779 BAIAP2 Two-hybrid physical 20936779 CDC42EP3 Two-hybrid physical 20936779 CDC42EP1 Two-hybrid physical 20936779 SYNE1 Two-hybrid physical 20936779 CDC42EP4 Two-hybrid physical 20936779 CDC42SE1 Two-hybrid physical 20936779 PAK6 Two-hybrid physical 20936779 PAK7 Two-hybrid physical 20936779 PARD6B Two-hybrid physical 20936779 FMNL2 Two-hybrid physical 20936779 SH3D19 Two-hybrid physical 20936779 KIAA2026 Two-hybrid physical 20936779 MUC12 Two-hybrid physical 20936779 CBL Affinity Capture-Western physical 14505571 ARHGEF7 Affinity Capture-Western physical 14505571 ARHGEF7 Reconstituted Complex physical 14505571 CBL Reconstituted Complex physical 14505571 TNF Affinity Capture-MS physical 15485837 TNK2 Affinity Capture-Western physical 20086093 CDKN1A Reconstituted Complex physical 18057010 CBLL1 Reconstituted Complex physical 18057010 CDH1 Reconstituted Complex physical 18057010 CDH1 Affinity Capture-Western physical 18057010 CBLL1 Co-localization physical 18057010 MARK4 Affinity Capture-MS physical 14676191 PARD6B Affinity Capture-MS physical 14676191 PARD6G Affinity Capture-MS physical 14676191 PARD6A Affinity Capture-MS physical 14676191 A2M Two-hybrid physical 18624398 AHSG Two-hybrid physical 18624398 APOH Two-hybrid physical 18624398 CPN1 Two-hybrid physical 18624398 ETFA Two-hybrid physical 18624398 CFHR4 Two-hybrid physical 18624398 LGALS1 Two-hybrid physical 18624398 ZNF234 Two-hybrid physical 18624398 ARHGDIA Two-hybrid physical 21900206 GRB2 Two-hybrid physical 21900206