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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HDAC6 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000209 protein polyubiquitination IEA GO:0006476 protein deacetylation IMP GO:0006515 misfolded or incompletely synthesized protein catabolic process IMP GO:0006886 intracellular protein transport IMP GO:0007026 negative regulation of microtubule depolymerization IEA GO:0009636 response to toxin IMP GO:0009967 positive regulation of signal transduction IMP GO:0010033 response to organic substance IMP GO:0010469 regulation of receptor activity IMP GO:0010634 positive regulation of epithelial cell migration IMP GO:0010727 negative regulation of hydrogen peroxide metabolic process IC GO:0010870 positive regulation of receptor biosynthetic process IMP GO:0016236 macroautophagy IMP GO:0016568 chromatin modification IEA GO:0016575 histone deacetylation IDA GO:0016575 histone deacetylation ISS GO:0032418 lysosome localization IMP GO:0034983 peptidyl-lysine deacetylation IMP GO:0035967 cellular response to topologically incorrect protein IMP GO:0043065 positive regulation of apoptosis IMP GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA GO:0043242 negative regulation of protein complex disassembly IMP GO:0045861 negative regulation of proteolysis IMP GO:0045892 negative regulation of transcription, DNA-dependent ISS GO:0051354 negative regulation of oxidoreductase activity IC GO:0051788 response to misfolded protein IMP GO:0060632 regulation of microtubule-based movement IC GO:0060765 regulation of androgen receptor signaling pathway TAS GO:0070301 cellular response to hydrogen peroxide IMP GO:0070842 aggresome assembly IEA GO:0070842 aggresome assembly IMP GO:0070845 polyubiquitinated misfolded protein transport IMP GO:0070846 Hsp90 deacetylation IEA GO:0070846 Hsp90 deacetylation IMP GO:0070848 response to growth factor stimulus IMP GO:0071218 cellular response to misfolded protein IEA GO:0090035 positive regulation of cellular chaperone-mediated protein complex assembly IMP GO:0090042 tubulin deacetylation IDA GO:0090042 tubulin deacetylation IEA GO:0090042 tubulin deacetylation ISS cellular_component GO:0000118 histone deacetylase complex IDA GO:0005622 intracellular IMP GO:0005634 nucleus IDA GO:0005634 nucleus ISS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IEA GO:0005737 cytoplasm ISS GO:0005829 cytosol IEA GO:0005829 cytosol ISS GO:0005874 microtubule IDA GO:0005875 microtubule associated complex IDA GO:0005881 cytoplasmic microtubule IEA GO:0005901 caveola IDA GO:0016234 inclusion body IDA GO:0016235 aggresome IDA GO:0030286 dynein complex IDA GO:0031252 cell leading edge IDA GO:0043234 protein complex IEA GO:0048471 perinuclear region of cytoplasm IDA molecular_function GO:0003779 actin binding IEA GO:0004407 histone deacetylase activity IDA GO:0004407 histone deacetylase activity IEA GO:0005515 protein binding IPI GO:0008013 beta-catenin binding IPI GO:0008017 microtubule binding IDA GO:0008017 microtubule binding ISS GO:0008270 zinc ion binding IEA GO:0016787 hydrolase activity IEA GO:0019899 enzyme binding ISS GO:0031593 polyubiquitin binding IDA GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA GO:0034739 histone deacetylase activity (H3-K16 specific) IEA GO:0042826 histone deacetylase binding IPI GO:0042903 tubulin deacetylase activity IDA GO:0042903 tubulin deacetylase activity IEA GO:0042903 tubulin deacetylase activity ISS GO:0043014 alpha-tubulin binding IDA GO:0043130 ubiquitin binding IEA GO:0046872 metal ion binding IEA GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IEA GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) IEA GO:0048156 tau protein binding IDA GO:0048487 beta-tubulin binding IEA GO:0051879 Hsp90 protein binding IDA GO:0070840 dynein complex binding IDA

Protein-protein interaction details for HDAC6 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ZBTB16 Reconstituted Complex physical 15467736 ZBTB16 Affinity Capture-Western physical 15467736 RELB Affinity Capture-MS physical 14743216 HDAC11 Affinity Capture-Western physical 11948178 HDAC11 Affinity Capture-Western physical 11948178 BCOR Affinity Capture-Western physical 10898795 RUNX2 Affinity Capture-Western physical 12391164 CBFA2T3 Affinity Capture-Western physical 11533236 UBE2D1 Biochemical Activity physical 17588522 UBE2D3 Biochemical Activity physical 17588522 UBE2H Biochemical Activity physical 17588522 UBE2E1 Biochemical Activity physical 17588522 UBC Affinity Capture-Western physical 17512543 DNAJB6 Affinity Capture-Western physical 20159555 DNAJB8 Affinity Capture-Western physical 20159555 DNAJB8 Affinity Capture-Western physical 20159555 DNAJB6 Affinity Capture-Western physical 20159555 EGFR Affinity Capture-Western physical 20133936 EGFR Co-fractionation physical 20133936 EEA1 Co-fractionation physical 20133936 EP300 Affinity Capture-Western physical 19344692 EP300 Affinity Capture-Western physical 19344692 EGFR PCA physical 20029029 EGFR Affinity Capture-Western physical 20029029 EGFR Affinity Capture-Western physical 20029029 ERBB2 PCA physical 20029029 ERBB3 PCA physical 20029029 ERBB4 PCA physical 20029029 NR4A1 Affinity Capture-MS physical 19321449 FNTA Affinity Capture-Western physical 19228685 FNTB Affinity Capture-Western physical 19228685 FNTA Reconstituted Complex physical 19228685 FNTB Reconstituted Complex physical 19228685 HSP90AA1 Affinity Capture-Western physical 19158084 TARDBP Affinity Capture-RNA physical 19910924 CYLD Affinity Capture-Western physical 19893491 CYLD Reconstituted Complex physical 19893491 LCOR Reconstituted Complex physical 19744931 MAPRE1 Affinity Capture-Western physical 19737819 ACTR1A Affinity Capture-Western physical 19737819 PKN1 Affinity Capture-Western physical 19036992 PKN1 Reconstituted Complex physical 19036992 FAT1 Affinity Capture-Western physical 19033385 UBD Reconstituted Complex physical 19033385 SMAD7 Affinity Capture-Western physical 15831498 HIF1A Affinity Capture-Western physical 16951198 MAPT Reconstituted Complex physical 18636984 MAPT Affinity Capture-Western physical 18636984 HSP90AA1 Affinity Capture-Western physical 18591380 CFTR Affinity Capture-Western physical 14675537 PPP1CC Co-purification physical 14670976 PPP1CC Far Western physical 14670976 PPP1CC Affinity Capture-Western physical 14670976 PPP1CC Reconstituted Complex physical 14670976 SYK Affinity Capture-Western physical 16288017 SYK Reconstituted Complex physical 16288017 CORD1 Reconstituted Complex physical 12718889 PPA1 Affinity Capture-Western physical 16186112 TUBB2B Two-hybrid physical 12606581 TUBB2B Affinity Capture-Western physical 12606581 TUBB2B Reconstituted Complex physical 12606581 TUBA1A Biochemical Activity physical 12606581 LCOR Reconstituted Complex physical 12535528 LCOR Reconstituted Complex physical 12535528 LCOR Affinity Capture-Western physical 12535528 TUBA1A Biochemical Activity physical 12486003 CDKN1A Reconstituted Complex physical 16082198 TUBA1A Biochemical Activity physical 12024216 TUBB2A Biochemical Activity physical 12024216 DIAPH3 Affinity Capture-Western physical 15976449 HSP90AA1 Affinity Capture-Western physical 15937340 DYNLL1 Affinity Capture-Western physical 15937109 HSP90AA1 Affinity Capture-Western physical 15916966 NR0B2 Reconstituted Complex physical 15835920 SMAD7 Affinity Capture-Western physical 15831516 CTNNB1 Biochemical Activity physical 18356165 G3BP1 Affinity Capture-Western physical 18079183 G3BP1 Reconstituted Complex physical 18079183 SIRT2 Affinity Capture-Western physical 17516032 CTTN Reconstituted Complex physical 17643370 CTTN Affinity Capture-Western physical 17643370 CTTN Biochemical Activity physical 17643370 AURKA Biochemical Activity physical 17604723 AURKA Reconstituted Complex physical 17604723 HSPA5 Affinity Capture-Western physical 20371724 HSPA5 Affinity Capture-Western physical 20371724 TPPP Reconstituted Complex physical 20308065 NR3C1 Affinity Capture-Western physical 20018896 NR3C1 Affinity Capture-Western physical 20018896 NR3C1 Reconstituted Complex physical 20018896 MIIP Reconstituted Complex physical 20008322 MIIP Affinity Capture-Western physical 20008322 MIIP Affinity Capture-Western physical 20008322 MYD88 Affinity Capture-Western physical 20837465 MYD88 Affinity Capture-Western physical 20837465 BCL3 Affinity Capture-Western physical 15469820 POLA2 Two-hybrid physical 21900206 HES1 Two-hybrid physical 21900206 NASP Two-hybrid physical 21900206 FBP1 Two-hybrid physical 21900206 POLDIP2 Two-hybrid physical 21900206 BBS10 Two-hybrid physical 21900206 NACAD Two-hybrid physical 21900206 ZNF205 Two-hybrid physical 21900206 LPXN Two-hybrid physical 21900206 PRDX4 Two-hybrid physical 21900206 UBC Affinity Capture-MS physical 18781797 UBC Reconstituted Complex physical 21690293