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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HUWE1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000209 protein polyubiquitination IDA GO:0006284 base-excision repair IMP GO:0006464 protein modification process IEA GO:0006513 protein monoubiquitination IDA GO:0016574 histone ubiquitination IDA GO:0030154 cell differentiation IEA GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus ISS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA molecular_function GO:0003677 DNA binding ISS GO:0004842 ubiquitin-protein ligase activity IDA GO:0005488 binding IEA GO:0005515 protein binding IPI GO:0016874 ligase activity IEA GO:0016881 acid-amino acid ligase activity IEA

Protein-protein interaction details for HUWE1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MCL1 Affinity Capture-Western physical 16213503 MCL1 Biochemical Activity physical 16213503 CDC6 Two-hybrid physical 17567951 CDC6 Reconstituted Complex physical 17567951 CDC6 Affinity Capture-Western physical 17567951 USP49 Affinity Capture-MS physical 19615732 USP50 Affinity Capture-MS physical 19615732 USP7 Affinity Capture-MS physical 19615732 VCPIP1 Affinity Capture-MS physical 19615732 UBL4A Affinity Capture-MS physical 19615732 GIYD2 Affinity Capture-MS physical 19596235 ATM Affinity Capture-Western physical 17478428 PIAS2 Reconstituted Complex physical 16269333 MYC Reconstituted Complex physical 16269333 PIAS2 Affinity Capture-Western physical 16269333 MYC Affinity Capture-Western physical 16269333 MYC Biochemical Activity physical 16269333 NR1D1 Affinity Capture-Western physical 20534529 NR1D1 Affinity Capture-MS physical 20534529 CDK5RAP3 Affinity Capture-MS physical 20164180 MCL1 Affinity Capture-Western physical 21613222 MCL1 Reconstituted Complex physical 21613222 UBC Affinity Capture-MS physical 16196087 UBC Reconstituted Complex physical 20007713 HUWE1 Biochemical Activity physical 20007713 MCL1 Biochemical Activity physical 20007713 MYC Affinity Capture-MS physical 17314511 MCL1 Affinity Capture-Western physical 21907705 USP9X Affinity Capture-Western physical 21907705 MCL1 Affinity Capture-Western physical 21907705 PMAIP1 Affinity Capture-Western physical 21907705 CDKN2A Affinity Capture-Western physical 15989956 CDKN2A Reconstituted Complex physical 15989956 CDKN2A Affinity Capture-Western physical 15989956 HUWE1 Biochemical Activity physical 15989956 TP53 Reconstituted Complex physical 15989956 TP53 Affinity Capture-Western physical 15989956 TP53 Affinity Capture-Western physical 15989956 TP53 Biochemical Activity physical 15989956 POLB Biochemical Activity physical 19713937 MCL1 Affinity Capture-Western physical 20023629 USP9X Affinity Capture-Western physical 20023629 MCL1 Affinity Capture-Western physical 20023629 USP9X Affinity Capture-Western physical 20023629 FAF2 Affinity Capture-MS physical 18775313 UBXN1 Affinity Capture-MS physical 18775313 PIAS2 Biochemical Activity physical 20624960 PIAS2 Affinity Capture-Western physical 20624960 CALM1 Reconstituted Complex physical 15840729 CDKN2A Affinity Capture-MS physical 15989956 USP4 Affinity Capture-Western physical 21522127 USP4 Affinity Capture-Western physical 21522127 USP4 Biochemical Activity physical 21522127 UBC Affinity Capture-Western physical 21522127 PCNA Biochemical Activity physical 22203964 UBC Affinity Capture-MS physical 20639865 UBC Affinity Capture-MS physical 22108332 UBC Affinity Capture-MS physical 21987572 MCL1 Affinity Capture-Western physical 21730980