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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CDK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000084 S phase of mitotic cell cycle TAS GO:0000085 G2 phase of mitotic cell cycle TAS GO:0000086 G2/M transition of mitotic cell cycle TAS GO:0000216 M/G1 transition of mitotic cell cycle TAS GO:0000278 mitotic cell cycle TAS GO:0006260 DNA replication TAS GO:0006275 regulation of DNA replication TAS GO:0006468 protein phosphorylation TAS GO:0006813 potassium ion transport IEA GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS GO:0007049 cell cycle IDA GO:0007067 mitosis IEA GO:0007089 traversing start control point of mitotic cell cycle TAS GO:0007126 meiosis TAS GO:0007265 Ras protein signal transduction IEP GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation TAS GO:0016310 phosphorylation TAS GO:0016572 histone phosphorylation IDA GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint TAS GO:0045893 positive regulation of transcription, DNA-dependent IEA GO:0051298 centrosome duplication TAS GO:0051301 cell division IEA GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0060968 regulation of gene silencing IDA GO:0071732 cellular response to nitric oxide TAS cellular_component GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA GO:0000781 chromosome, telomeric region IEA GO:0000793 condensed chromosome IEA GO:0000805 X chromosome IEA GO:0000806 Y chromosome IEA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005667 transcription factor complex IEA GO:0005737 cytoplasm TAS GO:0005768 endosome IDA GO:0005813 centrosome TAS GO:0005829 cytosol TAS GO:0015030 Cajal body IDA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity TAS GO:0004674 protein serine/threonine kinase activity IEA GO:0004693 cyclin-dependent protein kinase activity IDA GO:0004693 cyclin-dependent protein kinase activity TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016301 kinase activity TAS GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0030332 cyclin binding IEA GO:0035173 histone kinase activity IDA

Protein-protein interaction details for CDK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CDKN3 Two-hybrid physical 12745075 CDKN1B Affinity Capture-Western physical 15619620 EPB41 Affinity Capture-MS physical 17353931 UBE2M Affinity Capture-MS physical 17353931 VHL Affinity Capture-MS physical 17353931 SORT1 Affinity Capture-MS physical 17353931 RADIL Affinity Capture-MS physical 17353931 NEDD8 Affinity Capture-MS physical 17353931 TSC22D1 Affinity Capture-MS physical 17353931 WDR8 Affinity Capture-MS physical 17353931 OGT Affinity Capture-MS physical 17353931 CASP4 Affinity Capture-MS physical 17353931 FBL Affinity Capture-MS physical 17353931 PTP4A3 Affinity Capture-MS physical 17353931 CDK15 Affinity Capture-MS physical 17353931 NAA25 Affinity Capture-MS physical 17353931 FAM113A Affinity Capture-MS physical 17353931 BRCA1 Affinity Capture-Western physical 8764100 BRCA1 Affinity Capture-Western physical 10373534 BRCA1 Reconstituted Complex physical 10373534 BRCA1 Affinity Capture-Western physical 10373534 CDKN1A Affinity Capture-Western physical 10878006 BCCIP Affinity Capture-Western physical 10878006 INCA1 Biochemical Activity physical 15159402 XRCC6 Biochemical Activity physical 15159402 RBM4 Biochemical Activity physical 15159402 SPDYA Affinity Capture-Western physical 12972555 CDKN1B Affinity Capture-Western physical 12972555 FEN1 Biochemical Activity physical 12853968 FEN1 Reconstituted Complex physical 12853968 CCNA2 Affinity Capture-Western physical 12853968 CDKN1A Affinity Capture-Western physical 12839982 CCNE1 Affinity Capture-Western physical 12839982 CDKN1A Reconstituted Complex physical 12839982 CDK2AP1 Reconstituted Complex physical 10938106 CDK2AP1 Affinity Capture-Western physical 10938106 CDK2AP1 Affinity Capture-Western physical 10938106 RB1 Biochemical Activity physical 10938106 POLA1 Biochemical Activity physical 10877824 CCNE1 Affinity Capture-Western physical 9891079 RBL2 Biochemical Activity physical 9891079 RBL1 Biochemical Activity physical 9891079 CCNB1 Affinity Capture-Western physical 9891079 CCNA1 Affinity Capture-Western physical 8565853 PPP2CA Co-purification physical 10934208 PPP2CA Biochemical Activity physical 10934208 PPM1B Biochemical Activity physical 10934208 PPM1B Co-purification physical 10934208 CDK6 Co-purification physical 10934208 CCNE1 Co-purification physical 1388288 CCNE1 Affinity Capture-Western physical 1388288 CDC25A Reconstituted Complex physical 8617791 CDKN1B Affinity Capture-Western physical 12417722 CDKN1A Affinity Capture-Western physical 12417722 CDKN3 Two-hybrid physical 8127873 CDKN3 Affinity Capture-Western physical 8127873 CNOT7 Affinity Capture-Western physical 10602502 CCNA1 Two-hybrid physical 9041194 CCNA1 Affinity Capture-Western physical 9041194 E2F1 Reconstituted Complex physical 7969176 TP53 Biochemical Activity physical 10884347 CDC6 Affinity Capture-Western physical 9566895 CCNE1 Reconstituted Complex physical 15004009 CDKN1B Affinity Capture-Western physical 15355997 SKP2 Affinity Capture-Western physical 15355997 RRN3 Reconstituted Complex physical 15004009 CDKN3 Two-hybrid physical 8242751 CDKN1A Two-hybrid physical 8242751 CDKN1A Reconstituted Complex physical 8242751 NPDC1 Reconstituted Complex physical 11042687 CCNB3 Reconstituted Complex physical 12185076 REL Affinity Capture-Western physical 9731206 CCNA1 Reconstituted Complex physical 11264176 MYBL2 Biochemical Activity physical 11264176 BRCA1 Reconstituted Complex physical 9244350 CDKN1B Affinity Capture-Western physical 12529437 CCNE1 Affinity Capture-Western physical 12529437 ORC1L Affinity Capture-Western physical 11931757 ORC1L Biochemical Activity physical 11931757 ORC2L Biochemical Activity physical 11931757 SKP2 Reconstituted Complex physical 10559858 CEBPA Co-fractionation physical 11684017 CEBPA Affinity Capture-Western physical 11684017 CEBPA Reconstituted Complex physical 11684017 CCNE2 Affinity Capture-Western physical 9858585 CKS1B Co-crystal Structure physical 8601310 BIRC5 Affinity Capture-Western physical 11069302 MCM4 Biochemical Activity physical 10748114 CDC25B Two-hybrid physical 7644510 CCNA1 Co-crystal Structure physical 10559988 MS4A3 Affinity Capture-Western physical 11781350 PCNA Affinity Capture-Western physical 10930425 LYN Affinity Capture-Western physical 10432313 RBL1 Biochemical Activity physical 11884610 RBL2 Reconstituted Complex physical 9188854 PRKCH Affinity Capture-Western physical 11175348 CDC5L Biochemical Activity physical 10827081 CCNE1 Reconstituted Complex physical 10827081 SKP2 Affinity Capture-Western physical 9858587 CDKN1A Affinity Capture-Western physical 9858587 UBE2A Biochemical Activity physical 11953320 CKS1B Affinity Capture-Western physical 17409098 CDKN1A Affinity Capture-Western physical 20102411 IKBKG Reconstituted Complex physical 20098747 IKBKG Affinity Capture-Western physical 20098747 IKBKG Two-hybrid physical 20098747 RB1 Biochemical Activity physical 19225156 CHAF1A Reconstituted Complex physical 16826239 CHAF1A Biochemical Activity physical 16826239 CNTN2 Affinity Capture-Western physical 16822311 CDT1 Affinity Capture-Western physical 15004027 MGMT Affinity Capture-Western physical 16226712 CCNA1 Affinity Capture-Western physical 16159883 CCNA2 Affinity Capture-Western physical 15647383 NOV Affinity Capture-Western physical 15647383 CDKN1A Affinity Capture-Western physical 15647383 CDKN1B Affinity Capture-Western physical 15647383 SP1 Biochemical Activity physical 11598016 CDKN1A Affinity Capture-Western physical 15557281 CDKN1B Affinity Capture-Western physical 15557281 CCNE1 Affinity Capture-Western physical 15557281 CCNA2 Affinity Capture-Western physical 15557281 TSPYL2 Biochemical Activity physical 11395479 FOXM1 Affinity Capture-Western physical 15024056 RB1 Biochemical Activity physical 15003538 HIST1H1A Biochemical Activity physical 17293600 CCNA1 Biochemical Activity physical 10652300 CDKN1A Affinity Capture-Western physical 20587660 CCNE1 Affinity Capture-Western physical 20587660 KAT2B Biochemical Activity physical 19483727 CCNA2 Biochemical Activity physical 19483727 EZH2 Biochemical Activity physical 20935635 CCNE1 Affinity Capture-Western physical 20837141 ARID4A Biochemical Activity physical 21148318 CDK7 Biochemical Activity physical 8692842 SKP2 Affinity Capture-Western physical 19686743 CCNA1 Affinity Capture-Western physical 19423708 UHRF2 Far Western physical 21952639 EP300 Reconstituted Complex physical 10330164 NPM1 Biochemical Activity physical 11278991 CEBPG Affinity Capture-Western physical 12757710 CCNB1 Affinity Capture-Western physical 20733051 CCNA2 Affinity Capture-Western physical 20733051 UBC Affinity Capture-MS physical 18781797