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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for DLC1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001843 neural tube closure ISS GO:0003007 heart morphogenesis ISS GO:0006917 induction of apoptosis IDA GO:0006919 activation of caspase activity IDA GO:0007010 cytoskeleton organization IEA GO:0007165 signal transduction IEA GO:0007202 activation of phospholipase C activity IEA GO:0007264 small GTPase mediated signal transduction TAS GO:0008285 negative regulation of cell proliferation IDA GO:0008285 negative regulation of cell proliferation IMP GO:0008360 regulation of cell shape IMP GO:0021575 hindbrain morphogenesis ISS GO:0030036 actin cytoskeleton organization ISS GO:0030336 negative regulation of cell migration IDA GO:0030336 negative regulation of cell migration IMP GO:0030900 forebrain development ISS GO:0032321 positive regulation of Rho GTPase activity IDA GO:0032321 positive regulation of Rho GTPase activity IMP GO:0032869 cellular response to insulin stimulus IEA GO:0032956 regulation of actin cytoskeleton organization IMP GO:0035024 negative regulation of Rho protein signal transduction IMP GO:0035307 positive regulation of protein dephosphorylation IDA GO:0048041 focal adhesion assembly ISS GO:0051056 regulation of small GTPase mediated signal transduction TAS GO:0051497 negative regulation of stress fiber assembly IDA cellular_component GO:0001725 stress fiber IEA GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005884 actin filament IEA GO:0005901 caveola IDA GO:0005925 focal adhesion IDA GO:0005925 focal adhesion IEA GO:0045121 membrane raft IEA molecular_function GO:0005096 GTPase activator activity IEA GO:0005100 Rho GTPase activator activity IDA GO:0005100 Rho GTPase activator activity IEA GO:0005100 Rho GTPase activator activity IMP GO:0005515 protein binding IPI GO:0017166 vinculin binding IEA GO:0030675 Rac GTPase activator activity IDA GO:0042169 SH2 domain binding IPI GO:0043274 phospholipase binding IEA

Protein-protein interaction details for DLC1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID WWC1 Reconstituted Complex physical 16684779 WWC1 Affinity Capture-Western physical 16684779 S100A10 Affinity Capture-Western physical 21372205 S100A10 Affinity Capture-Western physical 21372205