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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SH2B2 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001922B-1 B cell homeostasisIEA
GO:0007165signal transductionTAS
GO:0007399nervous system developmentIEA
GO:0007596blood coagulationTAS
GO:0008286insulin receptor signaling pathwayIEA
GO:0008286insulin receptor signaling pathwayISS
GO:0019221cytokine-mediated signaling pathwayIEA
GO:0019222regulation of metabolic processIEA
GO:0030036actin cytoskeleton organizationIEA
GO:0035556intracellular signal transductionIDA
GO:0035556intracellular signal transductionIEA
GO:0046425regulation of JAK-STAT cascadeIDA
GO:0046578regulation of Ras protein signal transductionIEA
GO:0050776regulation of immune responseIEA
GO:0050851antigen receptor-mediated signaling pathwayIEA
GO:0050873brown fat cell differentiationIEA
cellular_component
GO:0001725stress fiberIEA
GO:0001726ruffleIEA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0005884actin filamentIEA
GO:0005886plasma membraneIDA
molecular_function
GO:0004871signal transducer activityIEA
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activityIEA
GO:0005070SH3/SH2 adaptor activityIDA
GO:0005070SH3/SH2 adaptor activityIEA
GO:0008269JAK pathway signal transduction adaptor activityIDA

Protein-protein interaction details for SH2B2 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
JAK2Biochemical Activityphysical10374881
CBLReconstituted Complexphysical10374881
NTRK1Two-hybridphysical9856458
NTRK1Affinity Capture-Westernphysical9856458
GRB2Affinity Capture-Westernphysical9856458
CBLAffinity Capture-Westernphysical18273061
CBLCo-crystal Structurephysical15737992
CBLAffinity Capture-Westernphysical15737992