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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CHEK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000077 DNA damage checkpoint IEA GO:0000077 DNA damage checkpoint TAS GO:0006915 apoptosis IEA GO:0006974 response to DNA damage stimulus TAS GO:0007049 cell cycle IEA GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis IDA GO:0010332 response to gamma radiation IEA GO:0042770 signal transduction in response to DNA damage IDA GO:0042770 signal transduction in response to DNA damage IEA GO:0090399 replicative senescence NAS cellular_component GO:0000781 chromosome, telomeric region IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0016605 PML body IDA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004674 protein serine/threonine kinase activity IEA GO:0004674 protein serine/threonine kinase activity TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for CHEK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MSH2 Affinity Capture-Western physical 15647386 BRCA1 Reconstituted Complex physical 10724175 BRCA1 Affinity Capture-Western physical 10724175 MDC1 Affinity Capture-Western physical 12607004 MDC1 Reconstituted Complex physical 12607004 MSH2 Reconstituted Complex physical 12447371 MSH2 Affinity Capture-Western physical 12447371 PLK3 Biochemical Activity physical 12242661 PLK3 Affinity Capture-Western physical 12242661 PLK1 Affinity Capture-Western physical 12493754 PLK1 Affinity Capture-Western physical 12493754 PLK1 Biochemical Activity physical 12493754 GINS2 Affinity Capture-Western physical 17525332 VCP Affinity Capture-Western physical 17525332 BRCA2 Affinity Capture-Western physical 17525332 RAD50 Affinity Capture-Western physical 17525332 TP53BP1 Affinity Capture-Western physical 17525332 GINS2 Affinity Capture-Western physical 17525332 MUS81 Affinity Capture-Western physical 11741546 MUS81 Reconstituted Complex physical 11741546 BRCA1 Affinity Capture-Western physical 18804494 BRCA1 Biochemical Activity physical 18804494 CDC25A Biochemical Activity physical 18480045 MDM2 Biochemical Activity physical 16943424 MDM4 Biochemical Activity physical 16163388 FOXM1 Biochemical Activity physical 17101782 ATR Biochemical Activity physical 17035231 CDC25C Biochemical Activity physical 16705183 REV3L Biochemical Activity physical 18622427 TP53 Affinity Capture-Western physical 12810724 CDC25A Biochemical Activity physical 12759351 ATM Biochemical Activity physical 15064416 ATM Reconstituted Complex physical 15064416 ATM Biochemical Activity physical 10973490 ATR Biochemical Activity physical 10973490 AATF Reconstituted Complex physical 17157788 AATF Affinity Capture-Western physical 17157788 TP53 Biochemical Activity physical 10673501 CHEK2 Affinity Capture-Western physical 11901158 CHEK2 Reconstituted Complex physical 11901158 CHEK2 Biochemical Activity physical 11901158 CHEK2 Affinity Capture-Western physical 12024051 CHEK2 Reconstituted Complex physical 12024051 CHEK2 Biochemical Activity physical 12024051 CDC25C Biochemical Activity physical 12024051