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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PARP1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000723 telomere maintenance IEA GO:0006281 DNA repair TAS GO:0006284 base-excision repair IEA GO:0006355 regulation of transcription, DNA-dependent IEA GO:0006366 transcription from RNA polymerase II promoter TAS GO:0006471 protein ADP-ribosylation IDA GO:0016540 protein autoprocessing IEA GO:0032869 cellular response to insulin stimulus IDA GO:0040009 regulation of growth rate IEA GO:0042769 DNA damage response, detection of DNA damage IEA cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IEA GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm IEA GO:0005667 transcription factor complex IDA GO:0005730 nucleolus IDA molecular_function GO:0003677 DNA binding IEA GO:0003950 NAD+ ADP-ribosyltransferase activity IDA GO:0005515 protein binding IPI GO:0008134 transcription factor binding IPI GO:0008270 zinc ion binding IEA GO:0016757 transferase activity, transferring glycosyl groups IEA GO:0046872 metal ion binding IEA GO:0047485 protein N-terminus binding IPI GO:0051287 NAD binding IEA

Protein-protein interaction details for PARP1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID APTX Affinity Capture-Western physical 15555565 APTX Two-hybrid physical 15555565 TERF2IP Affinity Capture-MS physical 15100233 APTX Affinity Capture-Western physical 15044383 TP53 Affinity Capture-Western physical 15044383 APTX Affinity Capture-Western physical 15044383 XRCC1 Affinity Capture-Western physical 15044383 XRCC1 Affinity Capture-Western physical 15044383 APTX Reconstituted Complex physical 15044383 ZNF423 Affinity Capture-Western physical 14623329 ZNF423 Two-hybrid physical 14623329 PCNA Affinity Capture-Western physical 12930846 CDKN1A Reconstituted Complex physical 12930846 PARP3 Affinity Capture-Western physical 12640039 RBM14 Affinity Capture-Western physical 11443112 CENPA Affinity Capture-Western physical 12011073 CENPB Affinity Capture-Western physical 12011073 BUB3 Affinity Capture-Western physical 12011073 TAL1 Affinity Capture-MS physical 16407974 SWAP70 Co-purification physical 9642267 XRCC1 Two-hybrid physical 9584196 XRCC1 Reconstituted Complex physical 9584196 NCOA6 Affinity Capture-MS physical 12519782 RELA Affinity Capture-Western physical 11590148 RELA Reconstituted Complex physical 11590148 POLA1 Affinity Capture-Western physical 9518481 POLA2 Affinity Capture-Western physical 9518481 POLA1 Far Western physical 9518481 POLA2 Far Western physical 9518481 TP53 Far Western physical 9565608 MYBL2 Affinity Capture-Western physical 10744766 MYBL2 Reconstituted Complex physical 10744766 PARP2 Affinity Capture-Western physical 11948190 RPS3A Reconstituted Complex physical 11790116 BCL2 Reconstituted Complex physical 11790116 PTK2 Co-fractionation physical 18206965 RRP1B Affinity Capture-MS physical 19710015 H2AFY Affinity Capture-MS physical 17158748 USP36 Affinity Capture-MS physical 19615732 MEPCE Affinity Capture-MS physical 17643375 TAF13 Affinity Capture-MS physical 17643375 TCEA2 Affinity Capture-MS physical 17643375 AIRE Affinity Capture-MS physical 20085707 NEDD8 Affinity Capture-MS physical 16620772 GBAS Affinity Capture-MS physical 20562859 PRKAA1 Affinity Capture-MS physical 20562859 FOXO1 Affinity Capture-Western physical 19281796 FOXO1 Affinity Capture-Western physical 19281796 FOXO1 Reconstituted Complex physical 19281796 NRF1 Reconstituted Complex physical 19181665 HIST1H1A Biochemical Activity physical 17214964 PIAS4 Affinity Capture-Western physical 19779455 PIAS4 Reconstituted Complex physical 19779455 PIAS4 Reconstituted Complex physical 19779455 IMMT Affinity Capture-MS physical 19762472 IMMT Affinity Capture-Western physical 19762472 BANF1 Affinity Capture-MS physical 19759913 BANF1 Affinity Capture-Western physical 19759913 CHD1L Affinity Capture-MS physical 19666485 CHD1L Affinity Capture-MS physical 19661379 SENP1 Biochemical Activity physical 19622798 SENP3 Biochemical Activity physical 19622798 EP300 Affinity Capture-Western physical 19622798 HSPA2 Affinity Capture-Western physical 19607827 HSPA2 Biochemical Activity physical 19607827 LZTR1 Two-hybrid physical 20211142 TRIM29 Two-hybrid physical 20211142 ZBTB9 Two-hybrid physical 20211142 MYB Affinity Capture-Western physical 18945670 SMARCA1 Affinity Capture-Western physical 18922045 ESR1 Affinity Capture-Western physical 16794079 TOP2B Affinity Capture-Western physical 16794079 PRKDC Affinity Capture-Western physical 16794079 XRCC5 Affinity Capture-Western physical 16794079 XRCC6 Affinity Capture-Western physical 16794079 SUPT16H Biochemical Activity physical 16682447 TRIM28 Affinity Capture-Western physical 18676401 NCAPD2 Far Western physical 16543152 NCAPD2 Affinity Capture-Western physical 16543152 NCAPG Affinity Capture-Western physical 16543152 NCAPD2 Affinity Capture-Western physical 16543152 H2AFX Affinity Capture-MS physical 16522924 H2AFX Affinity Capture-Western physical 16522924 BUB1B Affinity Capture-Western physical 16449973 BUB1B Affinity Capture-Western physical 16449973 BUB1B Affinity Capture-MS physical 16449973 EP300 Biochemical Activity physical 16204234 CREBBP Biochemical Activity physical 16204234 EP300 Affinity Capture-Western physical 16204234 GTF2F1 Affinity Capture-Western physical 16204234 MED1 Affinity Capture-Western physical 16204234 MED14 Affinity Capture-Western physical 16204234 MED23 Affinity Capture-Western physical 16204234 MED24 Affinity Capture-Western physical 16204234 MED17 Affinity Capture-Western physical 16204234 MED7 Affinity Capture-Western physical 16204234 CDK8 Affinity Capture-Western physical 16204234 THRAP3 Affinity Capture-Western physical 16204234 MED6 Affinity Capture-Western physical 16204234 MED14 Reconstituted Complex physical 16204234 CDK8 Reconstituted Complex physical 16204234 HMGA1 Reconstituted Complex physical 16204234 GTF2F1 Reconstituted Complex physical 16204234 CDK8 Reconstituted Complex physical 16204234 EP300 Reconstituted Complex physical 16204234 GTF2F1 Reconstituted Complex physical 16204234 RELA Reconstituted Complex physical 16204234 NFKB1 Reconstituted Complex physical 16204234 PARP1 Reconstituted Complex physical 16204234 RELA Reconstituted Complex physical 16204234 NFKB1 Reconstituted Complex physical 16204234 HDAC1 Affinity Capture-Western physical 16204234 HDAC2 Affinity Capture-Western physical 16204234 HDAC3 Affinity Capture-Western physical 16204234 HDAC1 Reconstituted Complex physical 16204234 HDAC2 Reconstituted Complex physical 16204234 HDAC3 Reconstituted Complex physical 16204234 RARA Affinity Capture-Western physical 15808511 RARA Affinity Capture-Western physical 15808511 THRA Affinity Capture-Western physical 15808511 MED6 Reconstituted Complex physical 15808511 CDK8 Affinity Capture-Western physical 15808511 PARP1 Biochemical Activity physical 15737996 H2AFX Affinity Capture-MS physical 18406329 H2AFX Affinity Capture-Western physical 18406329 H2AFX Reconstituted Complex physical 18406329 HIF1A Affinity Capture-Western physical 18314489 CARM1 Affinity Capture-Western physical 18280497 RELA Affinity Capture-Western physical 18280497 EP300 Affinity Capture-Western physical 18280497 PRMT1 Affinity Capture-Western physical 18280497 EP300 Affinity Capture-Western physical 18280497 PRMT1 Affinity Capture-Western physical 18280497 RELA Affinity Capture-Western physical 18280497 HIST1H1C Affinity Capture-MS physical 18258596 HIST1H1C Affinity Capture-Western physical 18258596 HIST1H1C Reconstituted Complex physical 18258596 XRCC5 Affinity Capture-Western physical 10400681 XRCC6 Affinity Capture-Western physical 10400681 XRCC5 Affinity Capture-Western physical 10400681 XRCC6 Affinity Capture-Western physical 10400681 XRCC5 Reconstituted Complex physical 10400681 XRCC6 Reconstituted Complex physical 10400681 NFATC1 Affinity Capture-Western physical 18078995 NFATC1 Reconstituted Complex physical 18078995 SP1 Affinity Capture-Western physical 17961220 SP1 Affinity Capture-Western physical 17961220 SP1 Biochemical Activity physical 17961220 H3F3A Affinity Capture-MS physical 17403666 TOPORS Affinity Capture-MS physical 17803295 H2AFY Affinity Capture-MS physical 17322296 H2AFY Affinity Capture-Western physical 17322296 H2AFY Reconstituted Complex physical 17322296 THRA Affinity Capture-MS physical 17242407 THRB Affinity Capture-MS physical 17242407 PARP1 Co-crystal Structure physical 20388712 BMI1 Affinity Capture-Western physical 20668194 HDAC1 Affinity Capture-Western physical 20596014 HDAC2 Affinity Capture-Western physical 20596014 HDAC9 Affinity Capture-Western physical 20596014 CDKN1A Reconstituted Complex physical 20303835 PCNA Reconstituted Complex physical 20303835 POLB Reconstituted Complex physical 20303835 CDKN1A Affinity Capture-Western physical 20303835 PCNA Affinity Capture-Western physical 20303835 POLB Affinity Capture-Western physical 20303835 XRCC1 Affinity Capture-Western physical 20303835 CDKN1A Affinity Capture-Western physical 20302655 PCNA Affinity Capture-Western physical 20302655 POLB Affinity Capture-Western physical 20302655 XRCC1 Affinity Capture-Western physical 20302655 HIST2H2AA3 Reconstituted Complex physical 20525793 HIST1H2BA Reconstituted Complex physical 20525793 H3F3A Reconstituted Complex physical 20525793 HIST1H4C Reconstituted Complex physical 20525793 PARP3 Reconstituted Complex physical 20064938 HIST1H3E Affinity Capture-MS physical 20504901 H3F3A Affinity Capture-MS physical 20504901 H3F3A Affinity Capture-Western physical 20504901 HIST1H3E Affinity Capture-Western physical 20504901 CTCF Affinity Capture-Western physical 20038529 CTCF Affinity Capture-Western physical 20038529 CTCF Co-localization physical 20038529 H2AFX Affinity Capture-MS physical 20000738 H2AFX Affinity Capture-Western physical 20000738 UBC Affinity Capture-MS physical 16196087 RYK Affinity Capture-MS physical 21875946 KLF8 Affinity Capture-MS physical 21518760 KLF8 Affinity Capture-Western physical 21518760 KLF8 Affinity Capture-Western physical 21518760 KLF8 Reconstituted Complex physical 21518760 KLF8 Co-localization physical 21518760 USF1 Affinity Capture-Western physical 19303849 CTCF Affinity Capture-MS physical 14759373 HDAC5 Affinity Capture-MS physical 21081666 APLF Reconstituted Complex physical 17396150 APLF Reconstituted Complex physical 17396150 TOP1 Affinity Capture-MS physical 15848144 SUMO1 Affinity Capture-MS physical 19596686 SUMO1 Reconstituted Complex physical 19596686 APLF Reconstituted Complex physical 20098424 UBC Affinity Capture-Western physical 20639865 UBC Affinity Capture-MS physical 20639865 UBC Affinity Capture-MS physical 22118674 LIG3 Affinity Capture-MS physical 12897160 LIG3 Reconstituted Complex physical 12897160 LIG3 Two-hybrid physical 12897160 LIG3 Affinity Capture-Western physical 12897160 XRCC1 Affinity Capture-Western physical 12897160 UBC Affinity Capture-MS physical 18781797 HOXB7 Affinity Capture-MS physical 17308091 HOXB7 Reconstituted Complex physical 17308091 UBC Affinity Capture-MS physical 21987572 VHL Affinity Capture-MS physical 21942715 RNF146 Affinity Capture-MS physical 21825151 PCNA Reconstituted Complex physical 21690293 RNF146 Affinity Capture-Western physical 21825151 RNF146 Biochemical Activity physical 21825151 RNF146 Reconstituted Complex physical 21825151