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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for EGFR (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000902 cell morphogenesis IEA GO:0001503 ossification NAS GO:0001892 embryonic placenta development IEA GO:0001942 hair follicle development IEA GO:0006468 protein phosphorylation IEA GO:0006950 response to stress NAS GO:0007165 signal transduction IDA GO:0007165 signal transduction TAS GO:0007166 cell surface receptor linked signaling pathway IDA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA GO:0007173 epidermal growth factor receptor signaling pathway IDA GO:0007173 epidermal growth factor receptor signaling pathway NAS GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007202 activation of phospholipase C activity TAS GO:0007411 axon guidance TAS GO:0007435 salivary gland morphogenesis IEA GO:0008283 cell proliferation TAS GO:0008284 positive regulation of cell proliferation IDA GO:0016337 cell-cell adhesion IMP GO:0021795 cerebral cortex cell migration IEA GO:0030335 positive regulation of cell migration IMP GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S IDA GO:0035413 positive regulation of catenin import into nucleus IMP GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS GO:0042327 positive regulation of phosphorylation IDA GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling TAS GO:0043066 negative regulation of apoptosis IMP GO:0043406 positive regulation of MAP kinase activity IDA GO:0045429 positive regulation of nitric oxide biosynthetic process IDA GO:0046777 protein autophosphorylation IEA GO:0046777 protein autophosphorylation IMP GO:0048146 positive regulation of fibroblast proliferation IEA GO:0048546 digestive tract morphogenesis IEA GO:0050679 positive regulation of epithelial cell proliferation IDA GO:0050679 positive regulation of epithelial cell proliferation IEA GO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA GO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP GO:0050999 regulation of nitric-oxide synthase activity IDA GO:0051205 protein insertion into membrane TAS GO:0051897 positive regulation of protein kinase B signaling cascade IMP GO:0060571 morphogenesis of an epithelial fold IEA GO:0070141 response to UV-A IDA cellular_component GO:0000139 Golgi membrane IEA GO:0005576 extracellular region IEA GO:0005615 extracellular space NAS GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005768 endosome IDA GO:0005783 endoplasmic reticulum IEA GO:0005789 endoplasmic reticulum membrane IEA GO:0005794 Golgi apparatus IEA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane TAS GO:0016020 membrane IDA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA GO:0016323 basolateral plasma membrane IDA GO:0016323 basolateral plasma membrane IEA GO:0030122 AP-2 adaptor complex TAS GO:0030139 endocytic vesicle IEA GO:0031965 nuclear membrane IEA GO:0045121 membrane raft IDA GO:0048471 perinuclear region of cytoplasm IEA GO:0070435 Shc-EGFR complex ISS molecular_function GO:0000166 nucleotide binding IEA GO:0003690 double-stranded DNA binding NAS GO:0004710 MAP/ERK kinase kinase activity NAS GO:0004713 protein tyrosine kinase activity IDA GO:0004713 protein tyrosine kinase activity IMP GO:0004713 protein tyrosine kinase activity TAS GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS GO:0004716 receptor signaling protein tyrosine kinase activity IEA GO:0004871 signal transducer activity IEA GO:0004872 receptor activity IEA GO:0004888 transmembrane signaling receptor activity IDA GO:0005006 epidermal growth factor-activated receptor activity IDA GO:0005006 epidermal growth factor-activated receptor activity IEA GO:0005006 epidermal growth factor-activated receptor activity NAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016301 kinase activity IEA GO:0019899 enzyme binding IPI GO:0019903 protein phosphatase binding IPI GO:0030235 nitric-oxide synthase regulator activity IDA GO:0042802 identical protein binding IPI GO:0046982 protein heterodimerization activity IDA GO:0051015 actin filament binding IDA

Protein-protein interaction details for EGFR (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID DCN Two-hybrid physical 12105206 SHC1 Affinity Capture-MS physical 16729043 SH3BGRL Affinity Capture-MS physical 16729043 STAT5A Affinity Capture-MS physical 16729043 PTPN11 Affinity Capture-MS physical 16729043 CRK Affinity Capture-MS physical 16729043 CSK Affinity Capture-MS physical 16729043 CBLB Affinity Capture-MS physical 16729043 GRB2 Affinity Capture-MS physical 16729043 STAT5A Affinity Capture-Western physical 16729043 STAT3 Affinity Capture-Western physical 15485908 CTNNB1 Reconstituted Complex physical 9535896 CTNND1 Reconstituted Complex physical 9535896 JUP Reconstituted Complex physical 9535896 AR Affinity Capture-Western physical 15305378 AR Affinity Capture-Western physical 15288768 CTNNB1 Affinity Capture-Western physical 11950845 AR Co-localization physical 15305378 AR Co-localization physical 15288768 LRSAM1 Affinity Capture-Western physical 15256501 EGFR Affinity Capture-Western physical 14576349 CAMLG Affinity Capture-Western physical 12919676 PRKCA Affinity Capture-Western physical 12878187 PRKCA Affinity Capture-Western physical 12878187 HBEGF Affinity Capture-Western physical 12725245 TJP1 Affinity Capture-Western physical 12708492 GRB2 Affinity Capture-MS physical 12577067 ATP5C1 Two-hybrid physical 16169070 SGSM2 Two-hybrid physical 16169070 WAS Affinity Capture-Western physical 9307968 WAS Affinity Capture-Western physical 9307968 GRB2 Affinity Capture-Western physical 11960376 EGF Reconstituted Complex physical 12093292 INPPL1 Affinity Capture-Western physical 11349134 DUSP3 Biochemical Activity physical 1281549 AREG Reconstituted Complex physical 10085134 EGF Reconstituted Complex physical 10085134 GRB2 Affinity Capture-Western physical 10085134 PTK2 Affinity Capture-Western physical 10806474 CBLB Affinity Capture-Western physical 10086340 CBL Affinity Capture-Western physical 10086340 CBLC Affinity Capture-Western physical 10571044 CDH1 Affinity Capture-Western physical 10969083 MAPK14 Biochemical Activity physical 7535770 CTNNB1 Affinity Capture-Western physical 9233779 SHC1 Affinity Capture-Western physical 9544989 VAV1 Affinity Capture-Western physical 10938113 VAV2 Affinity Capture-Western physical 10938113 VAV3 Affinity Capture-Western physical 10938113 STAT1 Affinity Capture-Western physical 10358079 STAT3 Affinity Capture-Western physical 10358079 STAT5A Affinity Capture-Western physical 10358079 SRC Affinity Capture-Western physical 10358079 JAK2 Affinity Capture-Western physical 10358079 JAK2 Affinity Capture-Western physical 10358079 HTT Affinity Capture-Western physical 9079622 PTK6 Affinity Capture-Western physical 8940083 PTK2B Affinity Capture-Western physical 10777553 SRC Affinity Capture-Western physical 10777553 GRB2 Affinity Capture-Western physical 7527043 GRB2 Affinity Capture-Western physical 7527043 GRB2 Reconstituted Complex physical 7527043 DOK2 Reconstituted Complex physical 10508618 SOS1 Affinity Capture-Western physical 10675333 SOS2 Affinity Capture-Western physical 10675333 CDC25A Affinity Capture-Western physical 11912208 CDC25A Reconstituted Complex physical 11912208 CDC25A Biochemical Activity physical 11912208 CDC25A Affinity Capture-Western physical 11912208 NCK1 Reconstituted Complex physical 9362449 CRK Biochemical Activity physical 9642287 CRK Affinity Capture-Western physical 9642287 IGF1R Affinity Capture-Western physical 17047074 GRB2 Affinity Capture-Western physical 9050991 PRKAR1A Affinity Capture-Western physical 9050991 PRKACA Affinity Capture-Western physical 9050991 PLD2 Affinity Capture-Western physical 9837959 ARF4 Two-hybrid physical 12446727 ARF4 Affinity Capture-Western physical 12446727 MAP4K1 Co-fractionation physical 9346925 NCK2 Reconstituted Complex physical 9737977 EPS15 Affinity Capture-Western physical 9049247 SOS1 Affinity Capture-Western physical 9447973 ROS1 Affinity Capture-Western physical 11094073 PTPN6 Affinity Capture-Western physical 7673163 PTPN11 Affinity Capture-Western physical 7673163 SH2D3A Affinity Capture-Western physical 10187783 SH2D3A Affinity Capture-Western physical 10187783 PLSCR1 Co-fractionation physical 12009895 PLSCR1 Affinity Capture-Western physical 12009895 GRB2 Reconstituted Complex physical 8647858 GRB14 Reconstituted Complex physical 8647858 RASA1 Reconstituted Complex physical 8647858 GRB14 Reconstituted Complex physical 8647858 DCN Reconstituted Complex physical 12105206 GRB10 Reconstituted Complex physical 9506989 GRB2 Reconstituted Complex physical 7510700 SOS1 Reconstituted Complex physical 7510700 PTPN1 Co-crystal Structure physical 10889023 NCK1 Affinity Capture-Western physical 1333047 NRG1 Affinity Capture-Western physical 7730382 CD44 Affinity Capture-Western physical 12093135 PTPN6 Reconstituted Complex physical 9733788 PTPN6 Affinity Capture-Western physical 9733788 CBL Affinity Capture-Western physical 12061819 PLCG1 Affinity Capture-Western physical 12061819 SH3KBP1 Affinity Capture-Western physical 11894095 SH3KBP1 Affinity Capture-Western physical 12177062 PIK3C2B Reconstituted Complex physical 11533253 GRB2 Affinity Capture-Western physical 1322798 GRB2 Reconstituted Complex physical 1322798 SOCS1 Affinity Capture-Western physical 12070153 SOCS3 Affinity Capture-Western physical 12070153 STAT1 Affinity Capture-Western physical 12070153 GRB2 Affinity Capture-Western physical 10026169 NCK1 Affinity Capture-Western physical 10026169 NCK2 Affinity Capture-Western physical 10026169 DCN Reconstituted Complex physical 9988678 CAV1 Affinity Capture-Western physical 9374534 CAV3 Affinity Capture-Western physical 9374534 CAV1 Reconstituted Complex physical 9374534 CAV3 Reconstituted Complex physical 9374534 ERBB3 Affinity Capture-Western physical 10527633 TGFA Co-crystal Structure physical 12297049 CD82 Affinity Capture-Western physical 10985391 SNX6 Affinity Capture-Western physical 11279102 SNX1 Affinity Capture-Western physical 9819414 SNX2 Affinity Capture-Western physical 9819414 SNX4 Affinity Capture-Western physical 9819414 PLCG1 Affinity Capture-Western physical 9207933 STAT5B Affinity Capture-Western physical 10558875 RGS16 Affinity Capture-Western physical 11602604 CEBPB Affinity Capture-Western physical 12095417 MUC1 Affinity Capture-Western physical 11278868 SRC Affinity Capture-Western physical 10971656 CBLC Reconstituted Complex physical 10362357 CBLC Affinity Capture-Western physical 10362357 GAB1 Affinity Capture-Western physical 11432805 RIPK1 Affinity Capture-Western physical 11116146 MAP3K14 Affinity Capture-Western physical 11116146 PTPN1 Biochemical Activity physical 8621392 PDGFRB Affinity Capture-Western physical 9506992 SHC3 Affinity Capture-Western physical 9507002 CASP1 Biochemical Activity physical 11226410 EREG Affinity Capture-Luminescence physical 9419975 FER Affinity Capture-Western physical 7623846 MUC1 Affinity Capture-Western physical 11483589 MUC1 Biochemical Activity physical 11483589 NCK2 Affinity Capture-Western physical 9843575 ERBB2 Affinity Capture-Western physical 19060928 UBC Affinity Capture-Western physical 18632619 CBL Affinity Capture-Western physical 18316398 UBC Affinity Capture-Western physical 18316398 UBC Affinity Capture-Western physical 18508924 CBL Affinity Capture-Western physical 18508924 HGS Affinity Capture-Western physical 18508924 CBL Affinity Capture-Western physical 18273061 CBL Co-crystal Structure physical 18273061 UBC Affinity Capture-Western physical 17995934 CBL Affinity Capture-Western physical 17995934 NCAM1 Reconstituted Complex physical 17995934 UBC Affinity Capture-Western physical 17971399 CBL Affinity Capture-Western physical 17971399 GRB2 Affinity Capture-Western physical 17971399 CBL Affinity Capture-Western physical 17545148 UBC Affinity Capture-Western physical 17545148 CBL Affinity Capture-Western physical 17486068 ERBB2 Affinity Capture-Western physical 17486068 UBC Affinity Capture-Western physical 17382318 UBC Affinity Capture-Western physical 17101784 MUC1 Affinity Capture-Western physical 16983337 UBC Affinity Capture-Western physical 16983337 UBC Affinity Capture-Western physical 16983337 CBL Affinity Capture-Western physical 16969069 UBC Affinity Capture-Western physical 16969069 HDAC6 Affinity Capture-Western physical 20133936 HDAC6 Co-fractionation physical 20133936 UBC Affinity Capture-Western physical 16914641 AIP PCA physical 20029029 PSMA7 PCA physical 20029029 MEGF6 PCA physical 20029029 SORBS2 PCA physical 20029029 HEXIM1 PCA physical 20029029 AHSA1 PCA physical 20029029 ALDOA PCA physical 20029029 UROD PCA physical 20029029 UCHL1 PCA physical 20029029 HSP90B1 PCA physical 20029029 CBR1 PCA physical 20029029 FAH PCA physical 20029029 GOT1 PCA physical 20029029 RAB3A PCA physical 20029029 CSRP1 PCA physical 20029029 CFL1 PCA physical 20029029 EEF1G PCA physical 20029029 PRKAR1B PCA physical 20029029 ATIC PCA physical 20029029 STIP1 PCA physical 20029029 HSPA4 PCA physical 20029029 MDH1 PCA physical 20029029 PTGDS PCA physical 20029029 MATR3 PCA physical 20029029 SEPP1 PCA physical 20029029 OAZ1 PCA physical 20029029 PSMD4 PCA physical 20029029 TPI1 PCA physical 20029029 GABARAPL2 PCA physical 20029029 ARF6 PCA physical 20029029 CNTN2 PCA physical 20029029 FKBP4 PCA physical 20029029 AKAP12 PCA physical 20029029 PTPN12 PCA physical 20029029 PRDX1 PCA physical 20029029 AHNAK PCA physical 20029029 MAP3K12 PCA physical 20029029 GPM6B PCA physical 20029029 DCTN2 PCA physical 20029029 COL9A3 PCA physical 20029029 DYNC1H1 PCA physical 20029029 FKBP8 PCA physical 20029029 SPCS2 PCA physical 20029029 PDK3 PCA physical 20029029 UBE2V2 PCA physical 20029029 ADRM1 PCA physical 20029029 RAP1GDS1 PCA physical 20029029 HSPA8 PCA physical 20029029 PPP5C PCA physical 20029029 HSPA1A PCA physical 20029029 FN1 PCA physical 20029029 TPM1 PCA physical 20029029 KCTD9P2 PCA physical 20029029 TMCO3 PCA physical 20029029 CEND1 PCA physical 20029029 RUSC2 PCA physical 20029029 SPARCL1 PCA physical 20029029 C4orf49 PCA physical 20029029 PRCC PCA physical 20029029 AP2M1 PCA physical 20029029 NDN PCA physical 20029029 OLFM1 PCA physical 20029029 DNAJC4 PCA physical 20029029 VAPA PCA physical 20029029 HDAC6 PCA physical 20029029 STUB1 PCA physical 20029029 PIN4 PCA physical 20029029 MAST1 PCA physical 20029029 MOBKL3 PCA physical 20029029 HDAC6 Affinity Capture-Western physical 20029029 MAP3K12 Affinity Capture-Western physical 20029029 HSPA4 Affinity Capture-Western physical 20029029 HDAC6 Affinity Capture-Western physical 20029029 CCDC50 Affinity Capture-Western physical 16803894 CCDC50 Affinity Capture-Western physical 16803894 NEDD8 Affinity Capture-Western physical 16735510 UBC Affinity Capture-Western physical 16735510 NEDD8 Affinity Capture-Western physical 16735510 CAV1 Affinity Capture-Western physical 16407214 CBL Affinity Capture-Western physical 16246327 UBC Affinity Capture-Western physical 16246327 ERBB2 Affinity Capture-Western physical 16207817 UBC Affinity Capture-Western physical 16205628 UBC Affinity Capture-Western physical 16120644 USP8 Affinity Capture-Western physical 16120644 CBL Affinity Capture-Western physical 16105874 UBC Affinity Capture-Western physical 16105874 SRC Affinity Capture-Western physical 17158602 PCNA Affinity Capture-Western physical 17115032 PCNA Affinity Capture-Western physical 17115032 PCNA Biochemical Activity physical 17115032 EPS15 Affinity Capture-Western physical 15701692 EPN1 Affinity Capture-Western physical 15701692 UBC Affinity Capture-Western physical 15701692 CBL Affinity Capture-Western physical 15668240 UBC Affinity Capture-Western physical 15635092 UBC Affinity Capture-Western physical 15475003 PDCD6IP Affinity Capture-Western physical 15456872 SH3KBP1 Affinity Capture-Western physical 15456872 UBC Affinity Capture-Western physical 15456872 SH3GL2 Affinity Capture-Western physical 15456872 UBC Affinity Capture-Western physical 15345710 LRIG1 Affinity Capture-Western physical 15345710 LRIG1 Affinity Capture-Western physical 15282549 UBC Affinity Capture-Western physical 15282549 CBL Affinity Capture-Western physical 15282549 UBC Affinity Capture-Western physical 16702950 CBLB Affinity Capture-Western physical 16702950 CBLB Affinity Capture-Western physical 16702950 UBASH3A Affinity Capture-Western physical 15159412 UBASH3B Affinity Capture-Western physical 15159412 UBASH3A Affinity Capture-Western physical 15159412 CBL Affinity Capture-Western physical 15159412 UBC Affinity Capture-Western physical 15159412 UBASH3A Affinity Capture-Western physical 15107835 CBL Affinity Capture-Western physical 15107835 CBL Affinity Capture-Western physical 14505571 UBC Affinity Capture-Western physical 14505571 SH3KBP1 Affinity Capture-Western physical 12734385 CBL Affinity Capture-Western physical 12734385 UBC Affinity Capture-Western physical 12719435 UBC Affinity Capture-Western physical 12717448 CBL Affinity Capture-Western physical 12604776 CBL Affinity Capture-Western physical 12593795 UBC Affinity Capture-Western physical 12381737 UBC Affinity Capture-Western physical 12226085 UBC Affinity Capture-Western physical 12006662 UBC Affinity Capture-Western physical 12006493 HSP90AA1 Affinity Capture-Western physical 12006493 HSPA4 Affinity Capture-Western physical 12006493 UBC Affinity Capture-Western physical 11994282 SPRY2 Affinity Capture-Western physical 11983899 UBC Affinity Capture-Western physical 11983899 UBC Affinity Capture-Western physical 11864992 UBC Affinity Capture-Western physical 11823423 UBC Affinity Capture-Western physical 11493652 UBC Affinity Capture-Western physical 10788520 UBC Affinity Capture-Western physical 10617627 UBC Affinity Capture-Western physical 10428778 CBL Affinity Capture-Western physical 10428778 UBC Affinity Capture-Western physical 10369675 IGF1R Affinity Capture-Western physical 17307140 IGF1R Affinity Capture-Western physical 17307140 ERBB2 Affinity Capture-Western physical 17307140 GRB2 Affinity Capture-Western physical 17242169 CBL Affinity Capture-Western physical 17242169 UBC Affinity Capture-Western physical 19270726 TNK2 Affinity Capture-Western physical 20086093 UBC Affinity Capture-Western physical 19144635 CBL Affinity Capture-Western physical 21772844 UBC Affinity Capture-Western physical 21772844 NDFIP1 Affinity Capture-Western physical 20534535 NDFIP2 Affinity Capture-Western physical 20534535 UBC Affinity Capture-Western physical 20124286 CBL Affinity Capture-Western physical 20124286 GRB2 Affinity Capture-Western physical 20124286 SH3KBP1 Affinity Capture-Western physical 21635887 SH3KBP1 Affinity Capture-Western physical 21635887 EGFR Affinity Capture-Western physical 19225046 CBL Affinity Capture-Western physical 19225046 LGALS1 Affinity Capture-Western physical 19225046 LGALS3 Affinity Capture-Western physical 19225046 UBC Affinity Capture-Western physical 20359967 EPN1 Affinity Capture-Western physical 21226813 EPS15 Affinity Capture-Western physical 21226813 UBC Affinity Capture-Western physical 19213840 EPS15 Affinity Capture-Western physical 19109251 EPS15 Affinity Capture-Western physical 19109251 ZFYVE28 Co-localization physical 19460345 CBL Affinity Capture-MS physical 19531499 GRB2 Affinity Capture-MS physical 19531499 SOS1 Affinity Capture-MS physical 19531499 SHC1 Affinity Capture-MS physical 19531499 VAV2 Affinity Capture-MS physical 19531499 CBLB Affinity Capture-MS physical 19531499 UBC Affinity Capture-MS physical 19531499 PIK3R2 Affinity Capture-MS physical 19531499 SNRPD2 Affinity Capture-MS physical 19531499 ACTA2 Affinity Capture-MS physical 19531499 EGF Affinity Capture-MS physical 19531499 PIK3R1 Affinity Capture-MS physical 19531499 ERRFI1 Affinity Capture-MS physical 19531499 ATP5C1 Affinity Capture-MS physical 19531499 MTCO2L Affinity Capture-MS physical 19531499 YWHAZ Affinity Capture-MS physical 19531499 SOS2 Affinity Capture-MS physical 19531499 CBL Reconstituted Complex physical 19531499 GRB2 Reconstituted Complex physical 19531499 SOS1 Reconstituted Complex physical 19531499 SHC1 Reconstituted Complex physical 19531499 VAV2 Reconstituted Complex physical 19531499 UBC Reconstituted Complex physical 19531499 CBL Affinity Capture-Western physical 19531499 UBC Affinity Capture-Western physical 19531499 UBC Affinity Capture-Western physical 20215522 CAV1 Affinity Capture-Western physical 19446582 UBC Affinity Capture-Western physical 19446582 UBC Affinity Capture-Western physical 21275903 SMURF2 Affinity Capture-Western physical 21750651 SMURF2 Affinity Capture-Western physical 21750651 SMURF2 Reconstituted Complex physical 21750651 UBC Affinity Capture-Western physical 20736164 CBL Reconstituted Complex physical 20877636 GRB2 Affinity Capture-Western physical 21596750 INPPL1 Affinity Capture-Western physical 19713535 CBL Affinity Capture-Western physical 19713535 OTUD7B Affinity Capture-Western physical 22179831 UBC Affinity Capture-Western physical 22179831 CBL Affinity Capture-Western physical 22203672 UBC Affinity Capture-Western physical 16520378 CALM1 Affinity Capture-Western physical 14960328 CAV1 Affinity Capture-Western physical 12388423 UBC Affinity Capture-Western physical 15273720 UBC Affinity Capture-Western physical 15210722 CBL Co-localization physical 15210722 CBL Affinity Capture-Western physical 15210722 UBC Affinity Capture-Western physical 20940296 VAV2 Affinity Capture-Western physical 20940296 VAV2 Affinity Capture-Western physical 20940296 CBL Affinity Capture-Western physical 20940296 CBL Affinity Capture-Western physical 20940296