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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for GJA1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001701 in utero embryonic development IEA GO:0001764 neuron migration IEA GO:0001947 heart looping IEA GO:0002070 epithelial cell maturation IEA GO:0006810 transport TAS GO:0006915 apoptosis IEA GO:0006936 muscle contraction TAS GO:0007165 signal transduction IMP GO:0007267 cell-cell signaling IEA GO:0007507 heart development IEA GO:0007507 heart development TAS GO:0007512 adult heart development IEA GO:0008016 regulation of heart contraction IEA GO:0008285 negative regulation of cell proliferation IEA GO:0009268 response to pH IEA GO:0010232 vascular transport IEA GO:0010628 positive regulation of gene expression IEA GO:0010629 negative regulation of gene expression IEA GO:0015867 ATP transport IEA GO:0016044 cellular membrane organization TAS GO:0016264 gap junction assembly TAS GO:0034220 ion transmembrane transport TAS GO:0035050 embryonic heart tube development IEA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IMP GO:0043403 skeletal muscle tissue regeneration IEA GO:0043434 response to peptide hormone stimulus IEA GO:0045732 positive regulation of protein catabolic process IEA GO:0045844 positive regulation of striated muscle tissue development IEA GO:0048514 blood vessel morphogenesis IEA GO:0048812 neuron projection morphogenesis IEA GO:0051259 protein oligomerization IEA GO:0051924 regulation of calcium ion transport IEA GO:0060174 limb bud formation IEA cellular_component GO:0000139 Golgi membrane TAS GO:0005624 membrane fraction IEA GO:0005737 cytoplasm IEA GO:0005741 mitochondrial outer membrane IEA GO:0005764 lysosome IEA GO:0005769 early endosome IEA GO:0005771 multivesicular body IEA GO:0005783 endoplasmic reticulum IEA GO:0005789 endoplasmic reticulum membrane TAS GO:0005794 Golgi apparatus ISS GO:0005829 cytosol IEA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane ISS GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane TAS GO:0005916 fascia adherens IEA GO:0005921 gap junction ISS GO:0005922 connexon complex IEA GO:0016021 integral to membrane IEA GO:0030054 cell junction IEA GO:0030660 Golgi-associated vesicle membrane TAS GO:0045121 membrane raft ISS molecular_function GO:0004871 signal transducer activity IMP GO:0005102 receptor binding IEA GO:0005243 gap junction channel activity IEA GO:0015075 ion transmembrane transporter activity TAS GO:0017124 SH3 domain binding IEA GO:0022857 transmembrane transporter activity IEA GO:0030165 PDZ domain binding IEA

Protein-protein interaction details for GJA1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID S100A1 Affinity Capture-Western physical 12804600 MAPK7 Biochemical Activity physical 12637502 MAPK7 Affinity Capture-Western physical 12637502 GJA1 Co-fractionation physical 11739633 GJA3 Affinity Capture-Western physical 11739633 GJA5 Co-purification physical 11557558 CSNK1D Biochemical Activity physical 12270943 CSNK1D Affinity Capture-Western physical 12270943 TJP1 Affinity Capture-Western physical 9707407 TJP1 Two-hybrid physical 9707407 PRKCA Affinity Capture-Western physical 11273731 PRKCE Affinity Capture-Western physical 10679481 CAV1 Co-fractionation physical 11980479 CAV1 Affinity Capture-Western physical 11980479 CAV1 Reconstituted Complex physical 11980479 UBC Affinity Capture-Western physical 19907029 NEDD4 Affinity Capture-Western physical 19907029 UBC Affinity Capture-Western physical 19808888 UBC Co-localization physical 19808888 HGS Co-localization physical 19808888 TSG101 Co-localization physical 19808888 TJP1 Affinity Capture-Western physical 16944923 UBC Affinity Capture-Western physical 21554242 EPS15 Affinity Capture-Western physical 21554242 UBC Affinity Capture-Western physical 19835873 NEDD4 Affinity Capture-Western physical 19835873 NEDD4 Affinity Capture-Western physical 19835873 EPS15 Affinity Capture-Western physical 19835873 UBQLN4 Affinity Capture-Western physical 20940304 UBQLN4 Affinity Capture-Western physical 20940304