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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for GRIK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001662 behavioral fear response IEA GO:0006810 transport NAS GO:0006811 ion transport IEA GO:0006874 cellular calcium ion homeostasis IEA GO:0006886 intracellular protein transport IEA GO:0007215 glutamate signaling pathway TAS GO:0007268 synaptic transmission TAS GO:0019228 regulation of action potential in neuron IEA GO:0031557 induction of programmed cell death in response to chemical stimulus NAS GO:0042391 regulation of membrane potential IEA GO:0043113 receptor clustering IEA GO:0043524 negative regulation of neuron apoptosis IEA GO:0046328 regulation of JNK cascade IEA GO:0048169 regulation of long-term neuronal synaptic plasticity IEA GO:0048172 regulation of short-term neuronal synaptic plasticity IMP GO:0050804 regulation of synaptic transmission IDA GO:0050806 positive regulation of synaptic transmission IMP GO:0051402 neuron apoptosis IDA GO:0051967 negative regulation of synaptic transmission, glutamatergic IEA GO:0060079 regulation of excitatory postsynaptic membrane potential IEA GO:0060080 regulation of inhibitory postsynaptic membrane potential IEA cellular_component GO:0005624 membrane fraction IEA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane TAS GO:0016020 membrane IEA GO:0030054 cell junction IEA GO:0030424 axon IEA GO:0032839 dendrite cytoplasm IEA GO:0032983 kainate selective glutamate receptor complex IEA GO:0042734 presynaptic membrane IEA GO:0043195 terminal button IEA GO:0043204 perikaryon IEA GO:0045202 synapse IEA GO:0045211 postsynaptic membrane IEA molecular_function GO:0004872 receptor activity IEA GO:0004970 ionotropic glutamate receptor activity IEA GO:0005216 ion channel activity IEA GO:0005234 extracellular-glutamate-gated ion channel activity IEA GO:0015277 kainate selective glutamate receptor activity IDA GO:0030165 PDZ domain binding IEA GO:0031624 ubiquitin conjugating enzyme binding IEA GO:0031625 ubiquitin protein ligase binding IEA GO:0042803 protein homodimerization activity IEA

Protein-protein interaction details for GRIK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SDCBP Two-hybrid physical 12597860 PICK1 Two-hybrid physical 12597860 PICK1 Reconstituted Complex physical 12597860 SDCBP Reconstituted Complex physical 12597860 DLG4 Reconstituted Complex physical 12597860 GRIP1 Reconstituted Complex physical 12597860 DLG4 Affinity Capture-Western physical 12597860 SDCBP Affinity Capture-Western physical 12597860 PICK1 Affinity Capture-Western physical 12597860 GRID2 Affinity Capture-Western physical 12573530 GRID2 Affinity Capture-Western physical 12573530 GRIP1 Reconstituted Complex physical 11891216 SDCBP Reconstituted Complex physical 11891216 DLG4 Affinity Capture-Western physical 11279111 DLG1 Affinity Capture-Western physical 11279111 DLG4 Affinity Capture-Western physical 9808460 DLG3 Affinity Capture-Western physical 9808460 DLG1 Affinity Capture-Western physical 9808460 DLG4 Reconstituted Complex physical 9808460 GRIK5 Affinity Capture-Western physical 8288598 GRIA1 Affinity Capture-Western physical 8288598 GRIA2 Affinity Capture-Western physical 8288598 GRIK5 Affinity Capture-Western physical 9466455