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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HNF4A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006351 transcription, DNA-dependent IDA GO:0006357 regulation of transcription from RNA polymerase II promoter IDA GO:0006357 regulation of transcription from RNA polymerase II promoter IMP GO:0006591 ornithine metabolic process IMP GO:0006637 acyl-CoA metabolic process IEA GO:0006805 xenobiotic metabolic process IMP GO:0007164 establishment of tissue polarity IEA GO:0007548 sex differentiation IEA GO:0007596 blood coagulation IDA GO:0008285 negative regulation of cell proliferation IMP GO:0009749 response to glucose stimulus ISS GO:0010467 gene expression TAS GO:0010470 regulation of gastrulation IEA GO:0019216 regulation of lipid metabolic process IDA GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030154 cell differentiation IEA GO:0030308 negative regulation of cell growth IMP GO:0031018 endocrine pancreas development TAS GO:0032534 regulation of microvillus assembly IEA GO:0033159 negative regulation of protein import into nucleus, translocation IEA GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor TAS GO:0042493 response to drug IEA GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein IEA GO:0042593 glucose homeostasis ISS GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IEA GO:0045216 cell-cell junction organization IEA GO:0045722 positive regulation of gluconeogenesis IEA GO:0045723 positive regulation of fatty acid biosynthetic process IEA GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045930 negative regulation of mitotic cell cycle IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA GO:0050796 regulation of insulin secretion ISS GO:0051591 response to cAMP IEA GO:0055088 lipid homeostasis IMP GO:0055091 phospholipid homeostasis ISS GO:0060395 SMAD protein signal transduction IEA GO:0060398 regulation of growth hormone receptor signaling pathway NAS GO:0070328 triglyceride homeostasis ISS GO:2000189 positive regulation of cholesterol homeostasis ISS cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005667 transcription factor complex IEA GO:0005737 cytoplasm IDA molecular_function GO:0000062 fatty-acyl-CoA binding IEA GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS GO:0003677 DNA binding IDA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IEA GO:0003707 steroid hormone receptor activity IEA GO:0004872 receptor activity IEA GO:0005102 receptor binding IDA GO:0005496 steroid binding IEA GO:0005504 fatty acid binding IDA GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0016290 palmitoyl-CoA hydrolase activity IEA GO:0033613 activating transcription factor binding ISS GO:0042803 protein homodimerization activity IDA GO:0043565 sequence-specific DNA binding IEA GO:0044212 transcription regulatory region DNA binding IDA GO:0046872 metal ion binding IEA GO:0070491 repressing transcription factor binding IEA

Protein-protein interaction details for HNF4A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CREBBP Two-hybrid physical 9434765 ZNHIT3 Two-hybrid physical 11916906 SNCG Affinity Capture-MS physical 17353931 STK16 Affinity Capture-MS physical 17353931 RAD50 Affinity Capture-MS physical 17353931 PABPC4 Affinity Capture-MS physical 17353931 EXT2 Affinity Capture-MS physical 17353931 AR Co-localization physical 12944908 CTNNB1 Affinity Capture-Western physical 12944908 CTNNB1 Reconstituted Complex physical 12944908 CREBBP Affinity Capture-Western physical 9434765 CREBBP Reconstituted Complex physical 9434765 CREBBP Phenotypic Enhancement genetic 9434765 CREBBP Reconstituted Complex physical 10085149 NR0B2 Two-hybrid physical 10594021 NR0B2 Reconstituted Complex physical 10594021 NCOA1 Two-hybrid physical 9812974 NCOA2 Two-hybrid physical 9812974 TP53 Reconstituted Complex physical 11818510 SUB1 Affinity Capture-Western physical 11741883 PPARGC1B Reconstituted Complex physical 11733490 NR2C2 Two-hybrid physical 12522137 NR2C2 Affinity Capture-Western physical 12522137 NR2C2 Reconstituted Complex physical 12522137 MED23 Affinity Capture-Western physical 12089346 MED14 Affinity Capture-Western physical 12089346 MED1 Affinity Capture-Western physical 12089346 MED1 Reconstituted Complex physical 12089346 ZNHIT3 Reconstituted Complex physical 11916906 FOXO1 Reconstituted Complex physical 12519792 MED1 Reconstituted Complex physical 12101254 MED14 Reconstituted Complex physical 12101254 MED24 Reconstituted Complex physical 12101254 MED17 Reconstituted Complex physical 12101254 MED16 Reconstituted Complex physical 12101254 MED7 Reconstituted Complex physical 12101254 MED21 Reconstituted Complex physical 12101254 MED10 Reconstituted Complex physical 12101254 SP1 Affinity Capture-Western physical 19115260 SP1 Affinity Capture-Western physical 19115260 FOXO1 Affinity Capture-Western physical 19740748 PRMT1 Affinity Capture-Western physical 17052457 PRMT1 Reconstituted Complex physical 17052457 PRMT1 Biochemical Activity physical 17052457 PCBD1 Two-hybrid physical 20211142 NCOA6 Reconstituted Complex physical 18552123 CREBBP Reconstituted Complex physical 18552123 PPARGC1A Reconstituted Complex physical 18552123 TGS1 Reconstituted Complex physical 18552123 NR1I3 Reconstituted Complex physical 18552123 NCOA6 Reconstituted Complex physical 18552123 NCOR2 Reconstituted Complex physical 12205093 HDAC3 Reconstituted Complex physical 12205093 HDAC4 Reconstituted Complex physical 12205093 CTNNB1 Affinity Capture-Western physical 12944908 SP1 Reconstituted Complex physical 15651981 PPARGC1A Reconstituted Complex physical 15322103 PPARGC1A Reconstituted Complex physical 15322103 CREBBP Biochemical Activity physical 10882110 CREBBP Reconstituted Complex physical 10882110 XPO1 Reconstituted Complex physical 10882110 PPARGC1A Affinity Capture-Western physical 17636037 SREBF1 Reconstituted Complex physical 17636037 SIRT1 Affinity Capture-Western physical 20375098 VDR Affinity Capture-Western physical 20371703 VDR Affinity Capture-Western physical 20371703 MAPK3 Biochemical Activity physical 20371703 MAPK1 Biochemical Activity physical 20371703 SREBF2 Reconstituted Complex physical 20926756 PPARGC1A Reconstituted Complex physical 20926756 NR0B2 Reconstituted Complex physical 20516075 HNF4A Two-hybrid physical 15604093 PROX1 Two-hybrid physical 15604093 UBE2I Two-hybrid physical 15604093 NRIP1 Two-hybrid physical 15604093 NPPA Two-hybrid physical 15604093 PNRC1 Two-hybrid physical 15604093 COPS5 Two-hybrid physical 15604093 PNRC2 Two-hybrid physical 15604093 NCOA6 Two-hybrid physical 15604093 NR0B2 Two-hybrid physical 15604093 SMAD3 Affinity Capture-Western physical 10995777 SMAD4 Reconstituted Complex physical 10995777 SMAD3 Reconstituted Complex physical 10995777