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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IRF1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006366 transcription from RNA polymerase II promoter TAS GO:0007249 I-kappaB kinase/NF-kappaB cascade IEA GO:0007565 female pregnancy IEA GO:0007596 blood coagulation TAS GO:0009408 response to heat IEA GO:0010942 positive regulation of cell death IEA GO:0019221 cytokine-mediated signaling pathway TAS GO:0042512 negative regulation of tyrosine phosphorylation of Stat1 protein IEA GO:0043374 CD8-positive, alpha-beta T cell differentiation IEA GO:0045084 positive regulation of interleukin-12 biosynthetic process IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060337 type I interferon-mediated signaling pathway TAS GO:0060416 response to growth hormone stimulus IEA GO:0071260 cellular response to mechanical stimulus IEP GO:0071300 cellular response to retinoic acid IEA GO:0071347 cellular response to interleukin-1 IEA GO:0071356 cellular response to tumor necrosis factor IEA GO:0071359 cellular response to dsRNA IEA GO:0071375 cellular response to peptide hormone stimulus IEA cellular_component GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005829 cytosol TAS molecular_function GO:0000975 regulatory region DNA binding IEA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0043565 sequence-specific DNA binding IEA

Protein-protein interaction details for IRF1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID KAT2B Reconstituted Complex physical 10022868 KAT2A Reconstituted Complex physical 10022868 KAT2B Reconstituted Complex physical 10022868 STAT1 Affinity Capture-Western physical 10764778 STAT1 Reconstituted Complex physical 10764778 IRF8 Two-hybrid physical 9742224 HMGA1 Reconstituted Complex physical 10357819 IRF8 Affinity Capture-Western physical 7768900 UBC Co-fractionation physical 17942705 STAT1 Affinity Capture-Western physical 16512786 IRF9 Two-hybrid physical 20211142 EP300 Affinity Capture-Western physical 14662860 EP300 Affinity Capture-Western physical 14662860 SMARCA4 Co-localization physical 16195385 CREBBP Reconstituted Complex physical 9659924 STUB1 Reconstituted Complex physical 20947504 STUB1 Affinity Capture-Western physical 20947504 STUB1 Reconstituted Complex physical 20947504 UBC Affinity Capture-Western physical 20947504 STUB1 Biochemical Activity physical 20947504 TRAF3 Affinity Capture-MS physical 21903422 HCFC1 Affinity Capture-MS physical 21903422 KEAP1 Affinity Capture-MS physical 21903422 SEC63 Affinity Capture-MS physical 21903422 TRMT2A Affinity Capture-MS physical 21903422 KEAP1 Reconstituted Complex physical 21903422 TRAF3 Reconstituted Complex physical 21903422