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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for JAK3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002731 negative regulation of dendritic cell cytokine production ISS GO:0006468 protein phosphorylation TAS GO:0007167 enzyme linked receptor protein signaling pathway ISS GO:0007204 elevation of cytosolic calcium ion concentration IEA GO:0007243 intracellular protein kinase cascade IEA GO:0007243 intracellular protein kinase cascade ISS GO:0007260 tyrosine phosphorylation of STAT protein TAS GO:0007262 STAT protein import into nucleus TAS GO:0018108 peptidyl-tyrosine phosphorylation ISS GO:0019221 cytokine-mediated signaling pathway IDA GO:0030183 B cell differentiation ISS GO:0032693 negative regulation of interleukin-10 production ISS GO:0032695 negative regulation of interleukin-12 production ISS GO:0042104 positive regulation of activated T cell proliferation IEA GO:0042506 tyrosine phosphorylation of Stat5 protein IEA GO:0042981 regulation of apoptosis ISS GO:0043029 T cell homeostasis ISS GO:0043029 T cell homeostasis TAS GO:0045087 innate immune response IEA GO:0045221 negative regulation of FasL biosynthetic process ISS GO:0045626 negative regulation of T-helper 1 cell differentiation ISS GO:0045768 positive regulation of anti-apoptosis ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046777 protein autophosphorylation IEA GO:0050778 positive regulation of immune response IEA GO:0050868 negative regulation of T cell activation ISS GO:0051928 positive regulation of calcium ion transport IEA GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS GO:0070232 regulation of T cell apoptosis ISS GO:0070244 negative regulation of thymocyte apoptosis ISS GO:0070669 response to interleukin-2 TAS GO:0070670 response to interleukin-4 IDA GO:0070672 response to interleukin-15 TAS GO:0071104 response to interleukin-9 TAS cellular_component GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0012505 endomembrane system IEA GO:0016020 membrane IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004713 protein tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA

Protein-protein interaction details for JAK3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TIAF1 Two-hybrid physical 10733938 STAT5A Two-hybrid physical 9047382 PRMT5 Reconstituted Complex physical 10531356 SHB Reconstituted Complex physical 12200137 PTK2B Affinity Capture-Western physical 9512511 CXCR4 Affinity Capture-Western physical 10506573 IL2RG Affinity Capture-Western physical 7973659 STAT5B Two-hybrid physical 9047382 ALK Affinity Capture-Western physical 11850821 LEPR Affinity Capture-Western physical 11585385 IL2RG Affinity Capture-Western physical 7973658 IRS1 Affinity Capture-Western physical 7499365 TIAF1 Affinity Capture-Western physical 10733938 CD3E Affinity Capture-Western physical 11349123 CD247 Affinity Capture-Western physical 11349123 CD247 Reconstituted Complex physical 11349123 STAM Affinity Capture-Western physical 9133424 STAM2 Affinity Capture-Western physical 10899310 ALK Affinity Capture-MS physical 14968112 IKBKG Reconstituted Complex physical 20098747 STAT5A Affinity Capture-Western physical 18250158 UHRF2 Far Western physical 21952639