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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for LCK (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006468 protein phosphorylation IDA GO:0006882 cellular zinc ion homeostasis IEP GO:0006882 cellular zinc ion homeostasis ISS GO:0006917 induction of apoptosis IMP GO:0006917 induction of apoptosis ISS GO:0006919 activation of caspase activity IDA GO:0006919 activation of caspase activity ISS GO:0007166 cell surface receptor linked signaling pathway IEA GO:0007568 aging IEA GO:0007596 blood coagulation TAS GO:0009612 response to mechanical stimulus IEA GO:0010043 response to zinc ion IEA GO:0016032 viral reproduction TAS GO:0018108 peptidyl-tyrosine phosphorylation IEA GO:0030097 hemopoiesis NAS GO:0030168 platelet activation TAS GO:0030217 T cell differentiation IMP GO:0030217 T cell differentiation ISS GO:0031295 T cell costimulation TAS GO:0035335 peptidyl-tyrosine dephosphorylation TAS GO:0042493 response to drug IDA GO:0042493 response to drug ISS GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein IEA GO:0042542 response to hydrogen peroxide IEA GO:0044419 interspecies interaction between organisms IEA GO:0045588 positive regulation of gamma-delta T cell differentiation IEA GO:0046777 protein autophosphorylation IEA GO:0050690 regulation of defense response to virus by virus TAS GO:0050852 T cell receptor signaling pathway TAS GO:0050853 B cell receptor signaling pathway IEA GO:0050862 positive regulation of T cell receptor signaling pathway NAS GO:0050870 positive regulation of T cell activation IDA GO:0050870 positive regulation of T cell activation ISS GO:0050900 leukocyte migration TAS GO:0051209 release of sequestered calcium ion into cytosol ISS GO:0051249 regulation of lymphocyte activation NAS GO:0070474 positive regulation of uterine smooth muscle contraction IEA cellular_component GO:0000242 pericentriolar material IDA GO:0000242 pericentriolar material ISS GO:0005737 cytoplasm IEA GO:0005794 Golgi apparatus IDA GO:0005829 cytosol TAS GO:0005886 plasma membrane IEA GO:0030139 endocytic vesicle IEA GO:0045121 membrane raft IDA GO:0045121 membrane raft ISS molecular_function GO:0000166 nucleotide binding IEA GO:0001948 glycoprotein binding IPI GO:0003823 antigen binding IEA GO:0004713 protein tyrosine kinase activity IDA GO:0004713 protein tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0004722 protein serine/threonine phosphatase activity IDA GO:0004722 protein serine/threonine phosphatase activity ISS GO:0004725 protein tyrosine phosphatase activity TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IPI GO:0019901 protein kinase binding IPI GO:0032403 protein complex binding IEA GO:0042169 SH2 domain binding IPI GO:0042169 SH2 domain binding ISS GO:0042609 CD4 receptor binding IPI GO:0042610 CD8 receptor binding IPI GO:0043548 phosphatidylinositol 3-kinase binding IPI GO:0051117 ATPase binding IPI

Protein-protein interaction details for LCK (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PIK3R1 Reconstituted Complex physical 8294442 UNC119 Affinity Capture-Western physical 14757743 UNC119 Reconstituted Complex physical 14757743 PIK3CA Affinity Capture-Western physical 14583609 NOTCH1 Affinity Capture-Western physical 14583609 NOTCH1 Affinity Capture-Western physical 14583609 CTNND1 Biochemical Activity physical 12835311 PTK2B Affinity Capture-Western physical 9091579 PTPRC Affinity Capture-Western physical 8473339 CD44 Affinity Capture-Western physical 8576267 CD44 Affinity Capture-Western physical 8576267 PRKCQ Two-hybrid physical 10383400 AXL Far Western physical 9178760 PTPN6 Biochemical Activity physical 10617656 UBE3A Two-hybrid physical 10449731 UBE3A Reconstituted Complex physical 10449731 CBL Affinity Capture-Western physical 11904433 BCAR1 Reconstituted Complex physical 9020138 PXN Affinity Capture-Western physical 9488700 KIT Affinity Capture-Western physical 9788619 NR2F2 Two-hybrid physical 8910285 NR2F2 Reconstituted Complex physical 8910285 SKAP1 Reconstituted Complex physical 9195899 PIK3CA Reconstituted Complex physical 8246987 PI4KA Reconstituted Complex physical 8246987 PTPRC Reconstituted Complex physical 8576115 SH2B3 Affinity Capture-Western physical 10799879 ARHGAP17 Reconstituted Complex physical 11431473 MS4A1 Affinity Capture-Western physical 7545683 PAG1 Reconstituted Complex physical 10790433 TRAT1 Reconstituted Complex physical 10790433 NEDD9 Affinity Capture-Western physical 8879209 CD48 Affinity Capture-Western physical 12007789 CD4 Affinity Capture-Western physical 12007789 ADAM15 Affinity Capture-Western physical 11741929 ADAM10 Affinity Capture-Western physical 11741929 ADAM15 Reconstituted Complex physical 11741929 ZAP70 Affinity Capture-Western physical 10318843 CD44 Co-fractionation physical 9573028 CD44 Affinity Capture-Western physical 9573028 FASLG Reconstituted Complex physical 11741599 CTLA4 Affinity Capture-Western physical 9712716 PECAM1 Biochemical Activity physical 9624175 FAS Reconstituted Complex physical 8864141 TRPV4 Affinity Capture-Western physical 12538589 KHDRBS1 Affinity Capture-Western physical 9045636 SIT1 Affinity Capture-Western physical 10209036 THY1 Affinity Capture-Western physical 1351058 SQSTM1 Reconstituted Complex physical 8650207 CD2 Affinity Capture-Western physical 8551220 CD2 Reconstituted Complex physical 8551220 CD4 Affinity Capture-Western physical 11854499 RASA1 Biochemical Activity physical 11389730 RAF1 Affinity Capture-Western physical 8939988 SYK Affinity Capture-Western physical 7539035 ZAP70 Affinity Capture-Western physical 7539035 SYK Reconstituted Complex physical 7539035 PTPN6 Biochemical Activity physical 11294838 PTPN6 Reconstituted Complex physical 8114715 DLG1 Affinity Capture-Western physical 9341123 DLG1 Reconstituted Complex physical 9341123 IKBKG Reconstituted Complex physical 20098747 PTPRC Affinity Capture-Western physical 15085197 UBC Affinity Capture-Western physical 12746907 UBC Affinity Capture-Western physical 20007709 CD4 Affinity Capture-MS physical 15047060 UBC Reconstituted Complex physical 19850743 UHRF2 Far Western physical 21952639 CSNK2B Two-hybrid physical 21900206