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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MCL1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001709 cell fate determination NAS GO:0006915 apoptosis IDA GO:0006916 anti-apoptosis TAS GO:0007275 multicellular organismal development IEA GO:0019725 cellular homeostasis NAS GO:0030154 cell differentiation IEA GO:0034097 response to cytokine stimulus IDA GO:0042981 regulation of apoptosis IEA cellular_component GO:0005634 nucleus IEA GO:0005654 nucleoplasm IEA GO:0005737 cytoplasm TAS GO:0005739 mitochondrion IDA GO:0005741 mitochondrial outer membrane TAS GO:0005759 mitochondrial matrix IEA GO:0016020 membrane IDA GO:0016021 integral to membrane IEA GO:0097136 Bcl-2 family protein complex IDA molecular_function GO:0005515 protein binding IPI GO:0015266 protein channel activity TAS GO:0046982 protein heterodimerization activity IPI GO:0051434 BH3 domain binding IPI

Protein-protein interaction details for MCL1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BAD Two-hybrid physical 11483855 BOK Two-hybrid physical 9356461 BMF Protein-peptide physical 15694340 BAD Protein-peptide physical 15694340 BIK Protein-peptide physical 15694340 HRK Protein-peptide physical 15694340 BID Protein-peptide physical 15694340 BCL2L11 Affinity Capture-Western physical 15694340 BBC3 Affinity Capture-Western physical 15694340 PMAIP1 Affinity Capture-Western physical 15694340 BAK1 Reconstituted Complex physical 15077116 BAK1 Affinity Capture-Western physical 15077116 BAK1 Affinity Capture-Western physical 15901672 BAK1 Protein-peptide physical 15901672 PMAIP1 Affinity Capture-Western physical 15901672 BAK1 Reconstituted Complex physical 15637055 BID Affinity Capture-Western physical 15637055 BID Reconstituted Complex physical 15637055 CASP3 Biochemical Activity physical 15637055 VDAC1 Reconstituted Complex physical 15637055 BAD Reconstituted Complex physical 11483855 MCL1 Two-hybrid physical 10837489 BAX Two-hybrid physical 10837489 BAK1 Two-hybrid physical 10837489 BCL2L11 Two-hybrid physical 10837489 MCL1 Affinity Capture-Western physical 10837489 BCL2L1 Affinity Capture-Western physical 10837489 PCNA Affinity Capture-Western physical 10978339 PCNA Reconstituted Complex physical 10978339 PCNA Two-hybrid physical 10978339 TNKS Two-hybrid physical 12475993 TNKS Affinity Capture-Western physical 12475993 TNKS Reconstituted Complex physical 12475993 DAD1 Two-hybrid physical 10965038 DAD1 Affinity Capture-Western physical 10965038 BCL2L11 Two-hybrid physical 9731710 MAPK10 Biochemical Activity physical 17670986 PIN1 Reconstituted Complex physical 17670986 UBC Affinity Capture-Western physical 17670986 PIN1 Affinity Capture-Western physical 17670986 HUWE1 Affinity Capture-Western physical 16213503 HUWE1 Biochemical Activity physical 16213503 UBC Affinity Capture-Western physical 16109713 BCL2L11 Affinity Capture-Western physical 20074640 HUWE1 Affinity Capture-Western physical 21613222 BCL2L11 Reconstituted Complex physical 21613222 BAK1 Reconstituted Complex physical 21613222 BBC3 Reconstituted Complex physical 21613222 BID Reconstituted Complex physical 21613222 PMAIP1 Reconstituted Complex physical 21613222 HUWE1 Reconstituted Complex physical 21613222 BIK Reconstituted Complex physical 21613222 UBC Affinity Capture-Western physical 21613222 UBC Affinity Capture-MS physical 16196087 HUWE1 Biochemical Activity physical 20007713 HUWE1 Affinity Capture-Western physical 21907705 UBC Affinity Capture-Western physical 21907705 USP9X Affinity Capture-Western physical 21907705 USP9X Affinity Capture-Western physical 21907705 HUWE1 Affinity Capture-Western physical 21907705 USP9X Affinity Capture-Western physical 20023629 HUWE1 Affinity Capture-Western physical 20023629 USP9X Affinity Capture-Western physical 20023629 HUWE1 Affinity Capture-Western physical 20023629 UBC Affinity Capture-Western physical 20023629 USP9X Biochemical Activity physical 20023629 UHRF2 Far Western physical 21952639 USP9X Affinity Capture-Western physical 21566062 UBC Affinity Capture-Western physical 21566062 UBC Affinity Capture-Western physical 19622586 BCL2L11 Affinity Capture-Western physical 19622586 UBC Affinity Capture-MS physical 18781797 UBC Affinity Capture-Western physical 21730980 HUWE1 Affinity Capture-Western physical 21730980 UBC Affinity Capture-Western physical 21730980 BBC3 Affinity Capture-Western physical 21730980