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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MYD88 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002224 toll-like receptor signaling pathway TAS GO:0002238 response to molecule of fungal origin IEA GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0006916 anti-apoptosis TAS GO:0007165 signal transduction IEA GO:0007165 signal transduction NAS GO:0007166 cell surface receptor linked signaling pathway TAS GO:0008063 Toll signaling pathway TAS GO:0009615 response to virus IEA GO:0016064 immunoglobulin mediated immune response IEA GO:0019221 cytokine-mediated signaling pathway IEA GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0032494 response to peptidoglycan IEA GO:0032496 response to lipopolysaccharide IEA GO:0032740 positive regulation of interleukin-17 production ISS GO:0032747 positive regulation of interleukin-23 production ISS GO:0032755 positive regulation of interleukin-6 production ISS GO:0032760 positive regulation of tumor necrosis factor production IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0042127 regulation of cell proliferation IEA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP GO:0044130 negative regulation of growth of symbiont in host IEA GO:0045080 positive regulation of chemokine biosynthetic process IEA GO:0045087 innate immune response TAS GO:0045351 type I interferon biosynthetic process IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046330 positive regulation of JNK cascade IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0050671 positive regulation of lymphocyte proliferation IEA GO:0050727 regulation of inflammatory response ISS GO:0050830 defense response to Gram-positive bacterium IEA GO:0051092 positive regulation of NF-kappaB transcription factor activity IEA GO:0070555 response to interleukin-1 IMP GO:0070935 3'-UTR-mediated mRNA stabilization IDA GO:0071260 cellular response to mechanical stimulus IEP cellular_component GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS GO:0010008 endosome membrane TAS GO:0031224 intrinsic to membrane IEA molecular_function GO:0004888 transmembrane signaling receptor activity IEA GO:0005121 Toll binding IEA GO:0005123 death receptor binding TAS GO:0005515 protein binding IPI GO:0070976 TIR domain binding IPI

Protein-protein interaction details for MYD88 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SPOP Two-hybrid physical 16189514 TLR2 Two-hybrid physical 15107846 TLR4 Two-hybrid physical 15107846 TLR5 Two-hybrid physical 15107846 TLR9 Two-hybrid physical 15107846 TLR3 Reconstituted Complex physical 12646618 TLR4 Reconstituted Complex physical 12646618 IRAK1 Affinity Capture-Western physical 11976320 RAC1 Reconstituted Complex physical 11416133 RAC1 Affinity Capture-Western physical 11416133 TLR4 Affinity Capture-Western physical 10952994 IRAK1 Affinity Capture-Western physical 10383454 IRAK2 Affinity Capture-Western physical 10383454 IRAK3 Affinity Capture-Western physical 10383454 IL1R1 Affinity Capture-Western physical 10854325 IRAK1 Affinity Capture-Western physical 11960013 IRAK4 Affinity Capture-Western physical 11960013 TIRAP Phenotypic Suppression genetic 11544529 TIRAP Two-hybrid physical 11544529 TIRAP Two-hybrid physical 11544529 MYD88 Two-hybrid physical 11544529 TIRAP Affinity Capture-Western physical 11544529 IRAK1 Phenotypic Suppression genetic 11544529 IRAK1 Affinity Capture-Western physical 11544529 IRAK2 Phenotypic Suppression genetic 11544529 TRAF6 Phenotypic Suppression genetic 11544529 MAP3K7 Phenotypic Suppression genetic 11544529 TLR4 Phenotypic Suppression genetic 11544529 IL1RAP Phenotypic Suppression genetic 11544529 IL1R1 Affinity Capture-Western physical 9374458 IRAK2 Affinity Capture-Western physical 9374458 IRF7 Affinity Capture-Western physical 16484229 IRF7 Two-hybrid physical 15361868 IRF7 Affinity Capture-Western physical 15361868 IRF7 FRET physical 15361868 LRRFIP1 Affinity Capture-Western physical 19265123 LRRFIP2 Affinity Capture-Western physical 19265123 FLII Affinity Capture-Western physical 19265123 FLII Affinity Capture-MS physical 19265123 CISH PCA physical 16961462 CISH Affinity Capture-Western physical 16961462 TIRAP PCA physical 17258210 TIRAP PCA physical 17258210 SARM1 PCA physical 17258210 TLR4 Affinity Capture-Western physical 17258210 TIRAP PCA physical 18221795 TLR4 PCA physical 18221795 IRAK4 PCA physical 18221795 IRAK4 PCA physical 18221795 TIRAP PCA physical 20048342 TLR4 PCA physical 20048342 TIRAP PCA physical 20048342 TIRAP Affinity Capture-Western physical 20048342 SQSTM1 Affinity Capture-Western physical 20837465 HDAC6 Affinity Capture-Western physical 20837465 HDAC6 Affinity Capture-Western physical 20837465 TLR4 Affinity Capture-Western physical 21911421 TLR9 Affinity Capture-Western physical 21911421 IRAK1 Affinity Capture-MS physical 21903422