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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for NBN (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000077 DNA damage checkpoint IDA GO:0000723 telomere maintenance IMP GO:0000724 double-strand break repair via homologous recombination TAS GO:0001701 in utero embryonic development IEA GO:0001832 blastocyst growth IEA GO:0006281 DNA repair TAS GO:0006302 double-strand break repair IDA GO:0006302 double-strand break repair TAS GO:0006915 apoptosis IEA GO:0007049 cell cycle IEA GO:0007050 cell cycle arrest TAS GO:0007095 mitotic cell cycle G2/M transition DNA damage checkpoint IDA GO:0007126 meiosis IEA GO:0008284 positive regulation of cell proliferation IEA GO:0030174 regulation of DNA-dependent DNA replication initiation TAS GO:0030330 DNA damage response, signal transduction by p53 class mediator TAS GO:0031575 mitotic cell cycle G1/S transition checkpoint IDA GO:0031576 G2/M transition checkpoint IEA GO:0031954 positive regulation of protein autophosphorylation IDA GO:0032508 DNA duplex unwinding IMP GO:0033674 positive regulation of kinase activity IDA GO:0042493 response to drug IEA GO:0045190 isotype switching IEA GO:0045665 negative regulation of neuron differentiation IEA GO:0048145 regulation of fibroblast proliferation IEA GO:0050885 neuromuscular process controlling balance IEA cellular_component GO:0000784 nuclear chromosome, telomeric region IDA GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005657 replication fork IEA GO:0005694 chromosome IEA GO:0005730 nucleolus IDA GO:0030870 Mre11 complex IDA GO:0042405 nuclear inclusion body IDA molecular_function GO:0003684 damaged DNA binding IC GO:0003684 damaged DNA binding IEA GO:0004003 ATP-dependent DNA helicase activity IMP GO:0005515 protein binding IPI GO:0008134 transcription factor binding IPI GO:0047485 protein N-terminus binding IPI

Protein-protein interaction details for NBN (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BLM Co-purification physical 10783165 MRE11A Co-purification physical 10783165 BRCA1 Co-purification physical 10783165 RAD50 Co-purification physical 10783165 BRCA1 Co-purification physical 11504724 H2AFX Affinity Capture-Western physical 12419185 H2AFX Reconstituted Complex physical 12419185 FANCD2 Affinity Capture-Western physical 12447395 MRE11A Affinity Capture-Western physical 12679336 RAD50 Affinity Capture-Western physical 12679336 ATM Protein-peptide physical 10608806 ATR Protein-peptide physical 10608806 ATM Co-purification physical 10783165 MLH1 Co-purification physical 10783165 MSH2 Co-purification physical 10783165 MSH6 Co-purification physical 10783165 BRCA1 Co-localization physical 10426999 RFC1 Co-purification physical 10783165 MDC1 Affinity Capture-Western physical 14519663 RAD50 Co-purification physical 9705271 MRE11A Co-purification physical 9705271 TERF1 Two-hybrid physical 10913111 XRCC4 Two-hybrid physical 18458108 MRE11A Two-hybrid physical 18458108 MRE11A Two-hybrid physical 11238951 MRE11A Affinity Capture-Western physical 11238951 RAD50 Affinity Capture-Western physical 11238951 MRE11A Co-localization physical 11238951 TERF2 Affinity Capture-Western physical 10888888 TERF2 Affinity Capture-Western physical 10888888 RECQL5 Affinity Capture-MS physical 19270065 RECQL5 Affinity Capture-Western physical 19270065 MRE11A Affinity Capture-Western physical 19270065 RECQL5 Reconstituted Complex physical 19270065 H2AFX Affinity Capture-Western physical 16932743 MCPH1 Co-localization physical 16872911 DDX1 Affinity Capture-Western physical 18710941 SUMO2 Affinity Capture-MS physical 19394292 MRE11A Affinity Capture-MS physical 12607003 MRE11A Affinity Capture-Western physical 12607003 RAD50 Affinity Capture-Western physical 12607003 MDC1 Affinity Capture-Western physical 12607003 RAD50 Affinity Capture-Western physical 12607003 MRE11A Affinity Capture-Western physical 12607003 MDC1 Affinity Capture-Western physical 12607003 ATF2 Affinity Capture-Western physical 15916964 ATF2 Co-localization physical 15916964 WRN Affinity Capture-Western physical 15733840 H2AFX Reconstituted Complex physical 15733840 H2AFX Affinity Capture-Western physical 15201865 MDC1 Affinity Capture-Western physical 15201865 ATM Affinity Capture-Western physical 17507690 PAXIP1 Affinity Capture-Western physical 17500065 MRE11A Affinity Capture-Western physical 17500065 RAD50 Affinity Capture-Western physical 17500065 SIRT1 Affinity Capture-Western physical 17612497 SIRT1 Reconstituted Complex physical 17612497 SIRT1 Biochemical Activity physical 17612497 MDC1 Affinity Capture-Western physical 20460517 HIST1H3A Affinity Capture-Western physical 21187428 TOPBP1 Affinity Capture-Western physical 17765870 TOPBP1 Affinity Capture-Western physical 17765870 KAT5 Affinity Capture-Western physical 20070254 MRE11A Affinity Capture-Western physical 12447395 RAD50 Affinity Capture-Western physical 12447395 WRN Affinity Capture-Western physical 20600238 WRN Affinity Capture-Western physical 20600238 EP300 Affinity Capture-MS physical 16051665 TUBG1 Co-fractionation physical 19244116 MRE11A Co-fractionation physical 19244116 BRCA1 Affinity Capture-Western physical 19244116 MRE11A Affinity Capture-Western physical 19244116 TUBG1 Affinity Capture-Western physical 19244116 RAD18 Affinity Capture-Western physical 21884979 RAD18 Reconstituted Complex physical 21884979 BARD1 Co-purification physical 16391231 BARD1 Affinity Capture-Western physical 16391231 RAD50 Affinity Capture-Western physical 16391231 BACH1 Affinity Capture-Western physical 16391231 RAD18 Affinity Capture-Western physical 21884979 MRE11A Affinity Capture-Western physical 21884979 RAD18 Reconstituted Complex physical 21884979 UBE2A Affinity Capture-Western physical 21884979 UBE2B Affinity Capture-Western physical 21884979 CD3EAP Affinity Capture-Western physical 21884979