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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TLR9 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002237 response to molecule of bacterial origin TAS GO:0007165 signal transduction IEA GO:0007252 I-kappaB phosphorylation IDA GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0030277 maintenance of gastrointestinal epithelium ISS GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA GO:0032715 negative regulation of interleukin-6 production ISS GO:0032717 negative regulation of interleukin-8 production IDA GO:0032722 positive regulation of chemokine production IDA GO:0032728 positive regulation of interferon-beta production ISS GO:0032733 positive regulation of interleukin-10 production ISS GO:0032735 positive regulation of interleukin-12 production ISS GO:0032741 positive regulation of interleukin-18 production ISS GO:0032755 positive regulation of interleukin-6 production IDA GO:0032757 positive regulation of interleukin-8 production IDA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0034122 negative regulation of toll-like receptor signaling pathway IDA GO:0034123 positive regulation of toll-like receptor signaling pathway IDA GO:0042346 positive regulation of NF-kappaB import into nucleus IDA GO:0042742 defense response to bacterium NAS GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IDA GO:0043507 positive regulation of JUN kinase activity IDA GO:0045078 positive regulation of interferon-gamma biosynthetic process IDA GO:0045087 innate immune response TAS GO:0045356 positive regulation of interferon-alpha biosynthetic process IDA GO:0045359 positive regulation of interferon-beta biosynthetic process IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0046330 positive regulation of JNK cascade IC GO:0050729 positive regulation of inflammatory response IC GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS cellular_component GO:0005576 extracellular region NAS GO:0005737 cytoplasm IDA GO:0005764 lysosome ISS GO:0005768 endosome ISS GO:0005783 endoplasmic reticulum ISS GO:0005789 endoplasmic reticulum membrane IEA GO:0005886 plasma membrane IDA GO:0010008 endosome membrane TAS GO:0016021 integral to membrane IEA GO:0016323 basolateral plasma membrane IDA GO:0016324 apical plasma membrane IDA GO:0031410 cytoplasmic vesicle IEA GO:0032009 early phagosome ISS molecular_function GO:0004872 receptor activity IEA GO:0004888 transmembrane signaling receptor activity IEA GO:0005149 interleukin-1 receptor binding IPI GO:0035197 siRNA binding IMP

Protein-protein interaction details for TLR9 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RNF216 Two-hybrid physical 15107846 RNF216 Two-hybrid physical 15107846 MYD88 Two-hybrid physical 15107846 STUB1 Affinity Capture-Western physical 21911421 MYD88 Affinity Capture-Western physical 21911421 IRAK1 Affinity Capture-Western physical 21911421 TRIM69 Affinity Capture-Western physical 21911421 TBK1 Affinity Capture-Western physical 21911421 TRAF6 Affinity Capture-Western physical 21911421 HSPA8 Affinity Capture-Western physical 21911421 SRC Affinity Capture-Western physical 21911421 PRKCZ Affinity Capture-Western physical 21911421 KIAA1274 Affinity Capture-MS physical 21903422 TRAF3 Affinity Capture-MS physical 21903422 UNC93B1 Affinity Capture-MS physical 21903422 CLGN Affinity Capture-MS physical 21903422 STK11IP Affinity Capture-MS physical 21903422 TOLLIP Affinity Capture-MS physical 21903422 UGGT1 Affinity Capture-MS physical 21903422