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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for REST (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0006351 transcription, DNA-dependent IDA GO:0006355 regulation of transcription, DNA-dependent NAS GO:0008285 negative regulation of cell proliferation IMP GO:0010629 negative regulation of gene expression IMP GO:0032348 negative regulation of aldosterone biosynthetic process IMP GO:0035690 cellular response to drug IMP GO:0043065 positive regulation of apoptosis IMP GO:0043280 positive regulation of caspase activity IMP GO:0043922 negative regulation by host of viral transcription IDA GO:0045665 negative regulation of neuron differentiation IMP GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045892 negative regulation of transcription, DNA-dependent NAS GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045955 negative regulation of calcium ion-dependent exocytosis ISS GO:0046676 negative regulation of insulin secretion IMP GO:0050768 negative regulation of neurogenesis ISS GO:0060379 cardiac muscle cell myoblast differentiation ISS GO:0070588 calcium ion transmembrane transport IMP GO:0070933 histone H4 deacetylation IDA GO:0071257 cellular response to electrical stimulus IMP GO:0071385 cellular response to glucocorticoid stimulus IDA GO:2000065 negative regulation of cortisol biosynthetic process IMP GO:2000706 negative regulation of dense core granule biogenesis ISS GO:2000740 negative regulation of mesenchymal stem cell differentiation IMP GO:2000798 negative regulation of amniotic stem cell differentiation IMP cellular_component GO:0000785 chromatin IEA GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus NAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol IEA GO:0017053 transcriptional repressor complex IDA molecular_function GO:0001046 core promoter sequence-specific DNA binding IDA GO:0001047 core promoter binding IDA GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA GO:0003676 nucleic acid binding IEA GO:0003677 DNA binding IEA GO:0003682 chromatin binding ISS GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0005262 calcium channel activity IMP GO:0005515 protein binding IPI GO:0008134 transcription factor binding IPI GO:0008270 zinc ion binding IEA GO:0015271 outward rectifier potassium channel activity IMP GO:0032403 protein complex binding IEA GO:0044212 transcription regulatory region DNA binding IDA GO:0046872 metal ion binding IEA

Protein-protein interaction details for REST (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RCOR1 Two-hybrid physical 10449787 RCOR1 Reconstituted Complex physical 10449787 RCOR1 Affinity Capture-Western physical 10449787 KDM5C Affinity Capture-MS physical 17468742 KDM5C Affinity Capture-MS physical 17468742 RNF2 Affinity Capture-MS physical 17468742 NCOR1 Affinity Capture-MS physical 17468742 HDAC2 Affinity Capture-MS physical 17468742 HDAC1 Reconstituted Complex physical 18806873 CDYL Affinity Capture-MS physical 19061646 CDYL Reconstituted Complex physical 19061646 SMARCA4 Affinity Capture-Western physical 17023429 HDAC5 Affinity Capture-Western physical 17011572 HDAC4 Affinity Capture-Western physical 17011572 HDAC5 Affinity Capture-Western physical 17011572 SMARCE1 Affinity Capture-Western physical 12192000 SMARCA4 Affinity Capture-Western physical 12192000 SMARCC2 Affinity Capture-Western physical 12192000 SMARCA4 Affinity Capture-Western physical 12192000 RCOR1 Affinity Capture-Western physical 15897453 SP1 Affinity Capture-Western physical 15528196 SP1 Affinity Capture-Western physical 15528196 TBP Reconstituted Complex physical 15197246 GTF2B Reconstituted Complex physical 15197246 TBP Affinity Capture-Western physical 15197246 SIN3B Affinity Capture-Western physical 15197246 SIN3A Affinity Capture-Western physical 10491605 HDAC1 Affinity Capture-Western physical 10491605 SUB1 Co-localization physical 20080105 SUB1 Co-localization physical 20080105 SUB1 Affinity Capture-Western physical 20080105 SUB1 Reconstituted Complex physical 20080105 UBC Affinity Capture-Western physical 21252229