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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SFRP1 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001649osteoblast differentiationIEP
GO:0001657ureteric bud developmentIEA
GO:0001756somitogenesisIEA
GO:0001843neural tube closureIEA
GO:0001944vasculature developmentIBA
GO:0001954positive regulation of cell-matrix adhesionISS
GO:0002244hemopoietic progenitor cell differentiationIDA
GO:0006309DNA fragmentation involved in apoptotic nuclear changeIDA
GO:0007420brain developmentIBA
GO:0008284positive regulation of cell proliferationIDA
GO:0008285negative regulation of cell proliferationIDA
GO:0008406gonad developmentIBA
GO:0008584male gonad developmentIEA
GO:0008585female gonad developmentIEA
GO:0009267cellular response to starvationIEP
GO:0009790embryo developmentIBA
GO:0009950dorsal/ventral axis specificationIDA
GO:0010564regulation of cell cycle processIMP
GO:0010629negative regulation of gene expressionIDA
GO:0010719negative regulation of epithelial to mesenchymal transitionIDA
GO:0014034neural crest cell fate commitmentIEA
GO:0014070response to organic cyclic compoundIDA
GO:0021915neural tube developmentIEA
GO:0022601menstrual cycle phaseIEP
GO:0030177positive regulation of Wnt receptor signaling pathwayIDA
GO:0030178negative regulation of Wnt receptor signaling pathwayIDA
GO:0030178negative regulation of Wnt receptor signaling pathwayIMP
GO:0030279negative regulation of ossificationIDA
GO:0030279negative regulation of ossificationIMP
GO:0030307positive regulation of cell growthIDA
GO:0030308negative regulation of cell growthIDA
GO:0030336negative regulation of cell migrationIDA
GO:0030514negative regulation of BMP signaling pathwayIEA
GO:0032855positive regulation of Rac GTPase activityISS
GO:0033689negative regulation of osteoblast proliferationIMP
GO:0035019somatic stem cell maintenanceIEA
GO:0042493response to drugIDA
GO:0043065positive regulation of apoptosisIDA
GO:0043065positive regulation of apoptosisIMP
GO:0043066negative regulation of apoptosisIMP
GO:0044344cellular response to fibroblast growth factor stimulusIDA
GO:0044345stromal-epithelial cell signaling involved in prostate gland developmentIEA
GO:0045578negative regulation of B cell differentiationIMP
GO:0045600positive regulation of fat cell differentiationIDA
GO:0045668negative regulation of osteoblast differentiationIEA
GO:0045671negative regulation of osteoclast differentiationIEA
GO:0045765regulation of angiogenesisISS
GO:0045880positive regulation of smoothened signaling pathwayIMP
GO:0045892negative regulation of transcription, DNA-dependentIDA
GO:0045892negative regulation of transcription, DNA-dependentIMP
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentIMP
GO:0046676negative regulation of insulin secretionIDA
GO:0046851negative regulation of bone remodelingIMP
GO:0048147negative regulation of fibroblast proliferationIDA
GO:0050679positive regulation of epithelial cell proliferationIMP
GO:0050680negative regulation of epithelial cell proliferationIDA
GO:0050732negative regulation of peptidyl-tyrosine phosphorylationIDA
GO:0051496positive regulation of stress fiber assemblyISS
GO:0051894positive regulation of focal adhesion assemblyISS
GO:0060070canonical Wnt receptor signaling pathwayIDA
GO:0060071Wnt receptor signaling pathway, planar cell polarity pathwayIEA
GO:0060218hemopoietic stem cell differentiationIDA
GO:0060346bone trabecula formationIEA
GO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisIEA
GO:0060687regulation of branching involved in prostate gland morphogenesisIEA
GO:0060766negative regulation of androgen receptor signaling pathwayIDA
GO:0071305cellular response to vitamin DIEP
GO:0071347cellular response to interleukin-1IEP
GO:0071356cellular response to tumor necrosis factorIDA
GO:0071363cellular response to growth factor stimulusIDA
GO:0071380cellular response to prostaglandin E stimulusIEP
GO:0071391cellular response to estrogen stimulusIDA
GO:0071392cellular response to estradiol stimulusIEP
GO:0071456cellular response to hypoxiaIEP
GO:0071481cellular response to X-rayIEA
GO:0071504cellular response to heparinIDA
GO:0071560cellular response to transforming growth factor beta stimulusIEP
GO:0071773cellular response to BMP stimulusIEP
GO:0090090negative regulation of canonical Wnt receptor signaling pathwayIDA
GO:0090090negative regulation of canonical Wnt receptor signaling pathwayIMP
GO:0090263positive regulation of canonical Wnt receptor signaling pathwayIDA
GO:2000052positive regulation of non-canonical Wnt receptor signaling pathwayIDA
GO:2000054negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specificationIDA
GO:2000080negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferationIDA
GO:2000117negative regulation of cysteine-type endopeptidase activityIMP
GO:2000270negative regulation of fibroblast apoptosisIDA
GO:2000271positive regulation of fibroblast apoptosisIDA
cellular_component
GO:0005576extracellular regionIEA
GO:0005578proteinaceous extracellular matrixIDA
GO:0005615extracellular spaceIDA
GO:0005622intracellularIDA
GO:0005829cytosolIDA
GO:0005886plasma membraneIBA
GO:0005886plasma membraneISS
GO:0009986cell surfaceIDA
GO:0031012extracellular matrixIDA
GO:0042995cell projectionISS
molecular_function
GO:0004197cysteine-type endopeptidase activityIMP
GO:0005109frizzled bindingIPI
GO:0008144drug bindingIDA
GO:0008201heparin bindingIDA
GO:0017147Wnt-protein bindingIPI
GO:0030165PDZ domain bindingIBA
GO:0042802identical protein bindingIPI
GO:0042813Wnt-activated receptor activityIBA

Protein-protein interaction details for SFRP1 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
WNT1Affinity Capture-Westernphysical10347172
WNT2Affinity Capture-Westernphysical10347172
FZD6Affinity Capture-Westernphysical10347172
FZD6Affinity Capture-Westernphysical10347172
WNT4Reconstituted Complexphysical11287180