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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for STAT1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006355 regulation of transcription, DNA-dependent TAS GO:0006366 transcription from RNA polymerase II promoter TAS GO:0006919 activation of caspase activity TAS GO:0007165 signal transduction TAS GO:0007249 I-kappaB kinase/NF-kappaB cascade TAS GO:0007259 JAK-STAT cascade TAS GO:0007260 tyrosine phosphorylation of STAT protein TAS GO:0009615 response to virus IEA GO:0009617 response to bacterium IEA GO:0019221 cytokine-mediated signaling pathway IEA GO:0019221 cytokine-mediated signaling pathway TAS GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0032496 response to lipopolysaccharide IEA GO:0043330 response to exogenous dsRNA IEA GO:0044419 interspecies interaction between organisms IEA GO:0060333 interferon-gamma-mediated signaling pathway IDA GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS GO:0060337 type I interferon-mediated signaling pathway TAS GO:0060338 regulation of type I interferon-mediated signaling pathway TAS cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS molecular_function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IDA GO:0003677 DNA binding TAS GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0004871 signal transducer activity IEA GO:0005509 calcium ion binding IEA GO:0005515 protein binding IPI GO:0043565 sequence-specific DNA binding IEA

Protein-protein interaction details for STAT1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PIAS1 Two-hybrid physical 10805787 LMO2 Two-hybrid physical 16189514 EIF1AD Two-hybrid physical 16189514 C20orf185 Affinity Capture-MS physical 17353931 FANCC Affinity Capture-Western physical 10848598 FANCC Two-hybrid physical 14499622 FANCC Affinity Capture-Western physical 11520787 GNB2L1 Affinity Capture-Western physical 12960323 TYK2 Biochemical Activity physical 12960323 IL27RA Affinity Capture-Western physical 12734330 IL27RA Reconstituted Complex physical 12734330 CREBBP Reconstituted Complex physical 8986769 CREBBP Phenotypic Enhancement genetic 8986769 EP300 Affinity Capture-Western physical 10464260 STAT3 Affinity Capture-Western physical 11594781 EIF2AK2 Affinity Capture-Western physical 9135145 EIF2AK2 Affinity Capture-Western physical 9135145 IL2RB Reconstituted Complex physical 10602027 STAT2 Co-purification physical 8621447 STAT1 Co-purification physical 8621447 STAT3 Affinity Capture-Western physical 11722592 KIT Affinity Capture-Western physical 9355737 KIT Affinity Capture-Western physical 9355737 KIT Reconstituted Complex physical 9355737 KIT Biochemical Activity physical 9355737 PTK2 Affinity Capture-Western physical 11278462 PTK2 Affinity Capture-Western physical 11278462 PTK2 Reconstituted Complex physical 11278462 IFNAR2 Reconstituted Complex physical 9121453 MCM5 Affinity Capture-Western physical 9843502 MCM5 Reconstituted Complex physical 9843502 EGFR Affinity Capture-Western physical 10358079 SRC Affinity Capture-Western physical 10358079 VDR Affinity Capture-Western physical 11909970 VDR Reconstituted Complex physical 11909970 HSF1 Affinity Capture-Western physical 9880553 TNFRSF1A Affinity Capture-Western physical 10848577 TRADD Affinity Capture-Western physical 10848577 TRADD Reconstituted Complex physical 10848577 MTOR Affinity Capture-Western physical 12807916 PRKCD Affinity Capture-Western physical 12807916 MTOR Affinity Capture-Western physical 12807916 PRKCD Affinity Capture-Western physical 12807916 STAT1 Two-hybrid physical 15284440 STAT1 Co-crystal Structure physical 9630226 ELP2 Reconstituted Complex physical 10954736 IRF1 Affinity Capture-Western physical 10764778 IRF1 Reconstituted Complex physical 10764778 SRC Affinity Capture-Western physical 9344858 IRF9 Two-hybrid physical 8943351 IRF9 Reconstituted Complex physical 8943351 JUN Affinity Capture-Western physical 10490649 JUN Affinity Capture-Western physical 10490649 GNB2L1 Reconstituted Complex physical 11301323 GNB2L1 Affinity Capture-Western physical 11301323 IFNAR2 Reconstituted Complex physical 11301323 EIF2AK2 Reconstituted Complex physical 11278865 EGFR Affinity Capture-Western physical 12070153 STAT3 Affinity Capture-Western physical 12070153 NMI Reconstituted Complex physical 9989503 GTF2I Reconstituted Complex physical 9584171 BRCA1 Affinity Capture-Western physical 10792030 BRCA1 Reconstituted Complex physical 10792030 BRCA1 Two-hybrid physical 10792030 STAT2 Co-localization physical 10446176 STAT2 Affinity Capture-Western physical 10446176 STAT2 Affinity Capture-Western physical 10446176 MCM5 Reconstituted Complex physical 11248027 MCM5 Affinity Capture-Western physical 11248027 STAT2 Reconstituted Complex physical 12048190 KPNA1 Reconstituted Complex physical 12048190 PIAS1 Reconstituted Complex physical 10805787 RNF11 Affinity Capture-Western physical 19131965 CREBBP Affinity Capture-Western physical 9037008 CREBBP Reconstituted Complex physical 9037008 IRF1 Affinity Capture-Western physical 16512786 PTPN2 Affinity Capture-Western physical 19171783 MBD1 Affinity Capture-Western physical 19074829 ACTN4 Two-hybrid physical 20936779 DCTN1 Two-hybrid physical 20936779 GFAP Two-hybrid physical 20936779 HSP90AB1 Two-hybrid physical 20936779 SPTAN1 Two-hybrid physical 20936779 SPTBN1 Two-hybrid physical 20936779 SHANK1 Two-hybrid physical 20936779 LZTR1 Two-hybrid physical 20211142 BCL3 Affinity Capture-Western physical 16306601 BCL3 Affinity Capture-Western physical 16306601 SMARCA4 Co-localization physical 16195385 EP300 Affinity Capture-Western physical 12403783 EP300 Affinity Capture-Western physical 11923478 CREBBP Affinity Capture-Western physical 15894584 CREBBP Reconstituted Complex physical 15695802 TRIM28 Affinity Capture-Western physical 18381204 CTNNBL1 Affinity Capture-MS physical 21385873 JAK2 Affinity Capture-Western physical 20353823 JAK2 Affinity Capture-Western physical 20353823 PRKCE Affinity Capture-Western physical 20353823 PRKCE Affinity Capture-Western physical 20353823 SMARCA4 Affinity Capture-Western physical 20353823 UBC Affinity Capture-MS physical 16335966 IFNGR1 Affinity Capture-Western physical 10848598 IFNGR1 Affinity Capture-Western physical 10848598 FANCC Reconstituted Complex physical 10848598 ATF3 Affinity Capture-Western physical 19647793 ATF3 Reconstituted Complex physical 19647793 UBC Affinity Capture-Western physical 19647793 SMARCA4 Affinity Capture-Western physical 21079652 SMARCA2 Affinity Capture-Western physical 21079652 STAT2 Affinity Capture-Western physical 17923090 MAVS Affinity Capture-MS physical 21903422 MAVS Reconstituted Complex physical 21903422 KPNA1 Reconstituted Complex physical 10964507